This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
CDK4
catalog :
11026-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, western blot knockout validation
citations: 109
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; 1:2000; loading ...; fig s3
Sang Y, Li Y, Zhang Y, Alvarez A, Yu B, Zhang W, et al. CDK5-dependent phosphorylation and nuclear translocation of TRIM59 promotes macroH2A1 ubiquitination and tumorigenicity. Nat Commun. 2019;10:4013 pubmed publisher
  • western blot; human; loading ...; fig 10a
  • immunohistochemistry - paraffin section; rat; 1:1000; loading ...; fig 9e
  • western blot; rat; loading ...; fig 7a
Zhang Y, Mao X, Chen W, Guo X, Yu L, Jiang F, et al. A Discovery of Clinically Approved Formula FBRP for Repositioning to Treat HCC by Inhibiting PI3K/AKT/NF-κB Activation. Mol Ther Nucleic Acids. 2020;19:890-904 pubmed publisher
  • western blot; mouse; loading ...; fig 5c
Feng F, Wang Z, Li R, Wu Q, Gu C, Xu Y, et al. Citrus alkaline extracts prevent fibroblast senescence to ameliorate pulmonary fibrosis via activation of COX-2. Biomed Pharmacother. 2019;112:108669 pubmed publisher
  • western blot; human; loading ...; fig 2c
Zhao Y, Zhang B, Lei Y, Sun J, Zhang Y, Yang S, et al. Knockdown of USP39 induces cell cycle arrest and apoptosis in melanoma. Tumour Biol. 2016;37:13167-13176 pubmed
Zhang D, Fan R, Lei L, Lei L, Wang Y, Lv N, et al. Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21Cip1 and p27Kip1. J Cell Mol Med. 2020;: pubmed publisher
Yan X, Yang C, Hu W, Chen T, Wang Q, Pan F, et al. Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway. Oncol Rep. 2020;44:103-114 pubmed publisher
Lv Z, Wu K, Qin X, Yuan J, Yan M, Zhang J, et al. A Novel Tumor Suppressor SPINK5 Serves as an Independent Prognostic Predictor for Patients with Head and Neck Squamous Cell Carcinoma. Cancer Manag Res. 2020;12:4855-4869 pubmed publisher
Zhang X, Luo Y, Li Q. TMED3 Promotes Proliferation and Migration in Breast Cancer Cells by Activating Wnt/β-Catenin Signaling. Onco Targets Ther. 2020;13:5819-5830 pubmed publisher
Wang L, Xu X, Liu T, Wang J, Shen J, Guo M, et al. 1-(4-((5-chloro-4-((2-(isopropylsulfonyl)phenyl)amino)pyrimidin-2-yl)amino)-3-methoxyphenyl)-3-(2-(dimethylamino)ethyl)imidazolidin-2-one (ZX-42), a novel ALK inhibitor, induces apoptosis and protective autophagy in H2228 cells. J Pharm Pharmacol. 2020;72:1370-1382 pubmed publisher
Lei X, Liu Y, Wang J, Cai Q, Yan M, He H, et al. SOX1 promotes differentiation of nasopharyngeal carcinoma cells by activating retinoid metabolic pathway. Cell Death Dis. 2020;11:331 pubmed publisher
Li H, Pan R, Lu Q, Ren C, Sun J, Wu H, et al. MicroRNA‑145‑5p inhibits osteosarcoma cell proliferation by targeting E2F transcription factor 3. Int J Mol Med. 2020;45:1317-1326 pubmed publisher
Peng F, Li G, Xie Y, Yin H, Li X, Yang Y. Compositional characterization of Pyrus ussuriensis Maxim and their antioxidant activities and induction of apoptosis in Bel-7402 cell. J Food Biochem. 2020;44:e13222 pubmed publisher
Pan H, Liu F, Wang J, Zhao M, Wang D, Jia C, et al. Dihydromethysticin, a natural molecule from Kava, suppresses the growth of colorectal cancer via the NLRC3/PI3K pathway. Mol Carcinog. 2020;59:575-589 pubmed publisher
Du S, Wang H, Cai J, Ren R, Zhang W, Wei W, et al. Apolipoprotein E2 modulates cell cycle function to promote proliferation in pancreatic cancer cells via regulation of the c-Myc-p21Waf1 signalling pathway. Biochem Cell Biol. 2020;98:191-202 pubmed publisher
Zhao Q, Zhu H, Xie X, Mao Q, Liu Y, He X, et al. Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways. Int J Mol Sci. 2020;21: pubmed publisher
Xie H, Li J, Ying Y, Yan H, Jin K, Ma X, et al. METTL3/YTHDF2 m6 A axis promotes tumorigenesis by degrading SETD7 and KLF4 mRNAs in bladder cancer. J Cell Mol Med. 2020;24:4092-4104 pubmed publisher
Liu A, Zuo Z, Liu L, Liu L. Down-regulation of NTSR3 inhibits cell growth and metastasis, as well as the PI3K-AKT and MAPK signaling pathways in colorectal cancer. Biochem Cell Biol. 2020;:1-8 pubmed publisher
Mao Y, Li W, Hua B, Gu X, Pan W, Chen Q, et al. Silencing of ELK3 Induces S-M Phase Arrest and Apoptosis and Upregulates SERPINE1 Expression Reducing Migration in Prostate Cancer Cells. Biomed Res Int. 2020;2020:2406159 pubmed publisher
Yang Y, Wei Q, Tang Y, Yuanyuan Wang -, Luo Q, Zhao H, et al. Loss of hnRNPA2B1 inhibits malignant capability and promotes apoptosis via down-regulating Lin28B expression in ovarian cancer. Cancer Lett. 2020;475:43-52 pubmed publisher
Ying Y, Li J, Xie H, Yan H, Jin K, He L, et al. CCND1, NOP14 and DNMT3B are involved in miR-502-5p-mediated inhibition of cell migration and proliferation in bladder cancer. Cell Prolif. 2020;53:e12751 pubmed publisher
Ji X, Shan L, Shen P, He M. Circular RNA circ_001621 promotes osteosarcoma cells proliferation and migration by sponging miR-578 and regulating VEGF expression. Cell Death Dis. 2020;11:18 pubmed publisher
Dang Y, An Y, He J, Huang B, Zhu J, Gao M, et al. Berberine ameliorates cellular senescence and extends the lifespan of mice via regulating p16 and cyclin protein expression. Aging Cell. 2020;19:e13060 pubmed publisher
Zhang C, Wang B, Wang X, Sheng X, Cui Y. Sevoflurane inhibits the progression of ovarian cancer through down-regulating stanniocalcin 1 (STC1). Cancer Cell Int. 2019;19:339 pubmed publisher
Chen Y, Huang F, Deng L, Yuan X, Tao Q, Wang T, et al. HIF-1-miR-219-SMC4 Regulatory Pathway Promoting Proliferation and Migration of HCC under Hypoxic Condition. Biomed Res Int. 2019;2019:8983704 pubmed publisher
Rui Y, Chen M, Li Y, Xiao L, Geng P, Wang P, et al. CTGF Attenuates Tendon-Derived Stem/Progenitor Cell Aging. Stem Cells Int. 2019;2019:6257537 pubmed publisher
Li Y, Zu X, Hu X, Wang L, He W. Forkhead Box R2 Knockdown Decreases Chemoresistance to Cisplatin via MYC Pathway in Bladder Cancer. Med Sci Monit. 2019;25:8928-8939 pubmed publisher
Chen J, Sun X, Mao Q, Jiang X, Zhao X, Xu W, et al. Increased expression of hematological and neurological expressed 1 (HN1) is associated with a poor prognosis of hepatocellular carcinoma and its knockdown inhibits cell growth and migration partly by down-regulation of c-Met. Kaohsiung J Med Sci. 2019;: pubmed publisher
Su D, Zhang D, Jin J, Ying L, Han M, Chen K, et al. Identification of predictors of drug sensitivity using patient-derived models of esophageal squamous cell carcinoma. Nat Commun. 2019;10:5076 pubmed publisher
Luo X, Wu X, Wei X, Wang A, Wang S, Wang J. LncRNA ADPGK-AS1 regulated cell proliferation, invasion, migration and apoptosis via targeting miR-542-3p in osteosarcoma. Eur Rev Med Pharmacol Sci. 2019;23:8751-8760 pubmed publisher
Gong H, Ni J, Xu Z, Huang J, Zhang J, Huang Y, et al. Shp2 in myocytes is essential for cardiovascular and neointima development. J Mol Cell Cardiol. 2019;137:71-81 pubmed publisher
Wang S, Hu H, Zhong B, Shi D, Qing X, Cheng C, et al. Bruceine D inhibits tumor growth and stem cell-like traits of osteosarcoma through inhibition of STAT3 signaling pathway. Cancer Med. 2019;8:7345-7358 pubmed publisher
Li S, Han J, Guo G, Sun Y, Zhang T, Zhao M, et al. Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation. FEBS Lett. 2019;: pubmed publisher
Li T, Wang F, Dang Y, Dong J, Zhang Y, Zhang C, et al. P21 and P27 promote tumorigenesis and progression via cell cycle acceleration in seminal vesicles of TRAMP mice. Int J Biol Sci. 2019;15:2198-2210 pubmed publisher
Wei C, Zhang R, Cai Q, Gao X, Tong F, Dong J, et al. MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer. Aging (Albany NY). 2019;11:6734-6761 pubmed publisher
Liu H, Feng X, Yang B, Tong R, Lu Y, Chen D, et al. Dimethyl fumarate suppresses hepatocellular carcinoma progression via activating SOCS3/JAK1/STAT3 signaling pathway. Am J Transl Res. 2019;11:4713-4725 pubmed
Wei Y, Liu P, Li Q, Du J, Chen Y, Wang Y, et al. The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines. Onco Targets Ther. 2019;12:6361-6370 pubmed publisher
Li X, Fu Y, Xia X, Zhang X, Xiao K, Zhuang X, et al. Knockdown of SP1/Syncytin1 axis inhibits the proliferation and metastasis through the AKT and ERK1/2 signaling pathways in non-small cell lung cancer. Cancer Med. 2019;: pubmed publisher
Que Z, Zhou Z, Luo B, Dong C, Jiang Y, Li H, et al. Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells. BMC Complement Altern Med. 2019;19:204 pubmed publisher
Diao H, Cheng N, Zhao Y, Xu H, Dong H, Thamm D, et al. Ivermectin inhibits canine mammary tumor growth by regulating cell cycle progression and WNT signaling. BMC Vet Res. 2019;15:276 pubmed publisher
Han Y, Liu C, Zhang D, Men H, Huo L, Geng Q, et al. Mechanosensitive ion channel Piezo1 promotes prostate cancer development through the activation of the Akt/mTOR pathway and acceleration of cell cycle. Int J Oncol. 2019;: pubmed publisher
Zhang W, Lu Y, Li X, Zhang J, Lin W, Zhang W, et al. IPO5 promotes the proliferation and tumourigenicity of colorectal cancer cells by mediating RASAL2 nuclear transportation. J Exp Clin Cancer Res. 2019;38:296 pubmed publisher
Wang Y, Chen L, Gu Y, Wang Y, Yuan Y, Zhu Q, et al. LncRNA FEZF1-AS1 Promotes TGF-β2-Mediated Proliferation and Migration in Human Lens Epithelial Cells SRA01/04. J Ophthalmol. 2019;2019:4736203 pubmed publisher
Huang L, Wang Y, Chen J, Wang Y, Zhao Y, Wang Y, et al. Long noncoding RNA PCAT1, a novel serum-based biomarker, enhances cell growth by sponging miR-326 in oesophageal squamous cell carcinoma. Cell Death Dis. 2019;10:513 pubmed publisher
Liu J, Min L, Zhu S, Guo Q, Li H, Zhang Z, et al. Cyclin-Dependent Kinase Inhibitor 3 Promoted Cell Proliferation by Driving Cell Cycle from G1 to S Phase in Esophageal Squamous Cell Carcinoma. J Cancer. 2019;10:1915-1922 pubmed publisher
Li S, Yu G, Huang W, Wang R, Pu P, Chen M. RING finger protein 10 is a potential drug target for diabetic vascular complications. Mol Med Rep. 2019;20:931-938 pubmed publisher
Cheng X, Tan S, Duan F, Yuan Q, Li Q, Deng G. Icariin induces apoptosis by suppressing autophagy in tamoxifen-resistant breast cancer cell line MCF-7/TAM. Breast Cancer. 2019;: pubmed publisher
Zheng M, Tian C, Fan T, Xu B. Fibronectin regulates the self-renewal of rabbit limbal epithelial stem cells by stimulating the Wnt11/Fzd7/ROCK non-canonical Wnt pathway. Exp Eye Res. 2019;185:107681 pubmed publisher
Liu H, Zhao J, Fu R, Zhu C, Fan D. The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway. PLoS ONE. 2019;14:e0216759 pubmed publisher
Gao Y, Zhu P, Xu S, Li Y, Deng J, Yang D. Ginsenoside Re inhibits PDGF-BB-induced VSMC proliferation via the eNOS/NO/cGMP pathway. Biomed Pharmacother. 2019;115:108934 pubmed publisher
Dong S, Ji J, Hu L, Wang H. Dihydromyricetin alleviates acetaminophen-induced liver injury via the regulation of transformation, lipid homeostasis, cell death and regeneration. Life Sci. 2019;227:20-29 pubmed publisher
Qin F, Wang Y, Jiang X, Wang Y, Zhang N, Wen X, et al. Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma. J Enzyme Inhib Med Chem. 2019;34:909-926 pubmed publisher
Yu Z, Jv Y, Cai L, Tian X, Huo X, Wang C, et al. Gambogic acid attenuates liver fibrosis by inhibiting the PI3K/AKT and MAPK signaling pathways via inhibiting HSP90. Toxicol Appl Pharmacol. 2019;371:63-73 pubmed publisher
Shen Z, Liao X, Shao Z, Feng M, Yuan J, Wang S, et al. Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability. BMC Cancer. 2019;19:262 pubmed publisher
Li W, Cao J, Liu J, Chu W, Zhang C, Chen S, et al. Downregulation of CDKL1 suppresses neuroblastoma cell proliferation, migration and invasion. Cell Mol Biol Lett. 2019;24:19 pubmed publisher
Chen J, Yu Y, Li H, Hu Q, Chen X, He Y, et al. Long non-coding RNA PVT1 promotes tumor progression by regulating the miR-143/HK2 axis in gallbladder cancer. Mol Cancer. 2019;18:33 pubmed publisher
Zhang X, Yu J, Zhao C, Ren H, Yuan Z, Zhang B, et al. MiR-181b-5p modulates chemosensitivity of glioma cells to temozolomide by targeting Bcl-2. Biomed Pharmacother. 2019;109:2192-2202 pubmed publisher
Zhao F, Zhou L, Ge Y, Ping W, Wu X, Xu Z, et al. MicroRNA-133b suppresses bladder cancer malignancy by targeting TAGLN2-mediated cell cycle. J Cell Physiol. 2019;234:4910-4923 pubmed publisher
Takahashi S, Tanaka N, Fukami T, Xie C, Yagai T, Kim D, et al. Role of Farnesoid X Receptor and Bile Acids in Hepatic Tumor Development. Hepatol Commun. 2018;2:1567-1582 pubmed publisher
Men L, Sun J, Ren D. Deficiency of VCP-Interacting Membrane Selenoprotein (VIMP) Leads to G1 Cell Cycle Arrest and Cell Death in MIN6 Insulinoma Cells. Cell Physiol Biochem. 2018;51:2185-2197 pubmed publisher
Hu R, Wang M, Niu W, Wang Y, Liu Y, Liu L, et al. SKA3 promotes cell proliferation and migration in cervical cancer by activating the PI3K/Akt signaling pathway. Cancer Cell Int. 2018;18:183 pubmed publisher
Xie F, Li Y, Wang M, Huang C, Tao D, Zheng F, et al. Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis. Mol Cancer. 2018;17:144 pubmed publisher
Zhao Q, Zhang X, Cai H, Zhang P, Kong D, Ge X, et al. Anticancer effects of plant derived Anacardic acid on human breast cancer MDA-MB-231 cells. Am J Transl Res. 2018;10:2424-2434 pubmed
Chen X, Liu C, Zhao R, Zhao P, Wu J, Zhou N, et al. Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells. Mol Pharm. 2018;15:4974-4984 pubmed publisher
Lu J, Chen J, Kang Y, Wu J, Shi H, Fu Y, et al. Jinfukang induces cellular apoptosis through activation of Fas and DR4 in A549 cells. Oncol Lett. 2018;16:4343-4352 pubmed publisher
Liu W, Fan Y, Shi Y, Lin Z, Huang X, Huang W, et al. Knockdown of TIPE2 increases the proliferation in lipopolysaccharide-stimulated gastric cancer cells. BMC Cancer. 2018;18:857 pubmed publisher
Xu X, Zheng Z, Jia L, Suo S, Liu B, Shao T, et al. Overexpression of SMARCA2 or CAMK2D is associated with cisplatin resistance in human epithelial ovarian cancer. Oncol Lett. 2018;16:3796-3804 pubmed publisher
Meng M, Chen Y, Jia J, Li L, Yang S. Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines. Biol Res. 2018;51:24 pubmed publisher
Wang W, Chen T, Xu H, Ren B, Cheng X, Qi R, et al. Curcumin-Loaded Solid Lipid Nanoparticles Enhanced Anticancer Efficiency in Breast Cancer. Molecules. 2018;23: pubmed publisher
Song H, Guo T, Zhao Z, Wei Y, Luo H, Weng W, et al. Biocompatible PEGylated Gold nanorods function As cytokinesis inhibitors to suppress angiogenesis. Biomaterials. 2018;178:23-35 pubmed publisher
Liu Y, Wang L, Chen S, Zong Z, Guan X, Zhao Y. LncRNA ABHD11-AS1 promotes the development of endometrial carcinoma by targeting cyclin D1. J Cell Mol Med. 2018;: pubmed publisher
Wu T, Lin Y, Xie Z. MicroRNA-1247 inhibits cell proliferation by directly targeting ZNF346 in childhood neuroblastoma. Biol Res. 2018;51:13 pubmed publisher
Lin Z, Zhou Z, Guo H, He Y, Pang X, Zhang X, et al. Long noncoding RNA gastric cancer-related lncRNA1 mediates gastric malignancy through miRNA-885-3p and cyclin-dependent kinase 4. Cell Death Dis. 2018;9:607 pubmed publisher
Li L, Qi Y, Ma X, Xiong G, Wang L, Bao C. TRIM22 knockdown suppresses chronic myeloid leukemia via inhibiting PI3K/Akt/mTOR signaling pathway. Cell Biol Int. 2018;42:1192-1199 pubmed publisher
Hou P, Kang Y, Luo J. Hypoxia-mediated miR-212-3p downregulation enhances progression of intrahepatic cholangiocarcinoma through upregulation of Rab1a. Cancer Biol Ther. 2018;:1-10 pubmed publisher
Yu Z, Tian X, Peng Y, Sun Z, Wang C, Tang N, et al. Mitochondrial cytochrome P450 (CYP) 1B1 is responsible for melatonin-induced apoptosis in neural cancer cells. J Pineal Res. 2018;65:e12478 pubmed publisher
Lin C, Zhang J, Lu Y, Li X, Zhang W, Zhang W, et al. NIT1 suppresses tumour proliferation by activating the TGFβ1-Smad2/3 signalling pathway in colorectal cancer. Cell Death Dis. 2018;9:263 pubmed publisher
Yun D, Wang Y, Meng D, Ji Y, Chen J, Chen H, et al. Actin-capping protein CapG is associated with prognosis, proliferation and metastasis in human glioma. Oncol Rep. 2018;39:1011-1022 pubmed publisher
Xiao Y, Tian C, Huang T, Han B, Wang M, Ma H, et al. 8-Cetylberberine inhibits growth of lung cancer in vitro and in vivo. Life Sci. 2018;192:259-269 pubmed publisher
Zeng G, Wang Z, Zhao L, Fan J, Tan N. NF-κB and JNK mediated apoptosis and G0/G1 arrest of HeLa cells induced by rubiarbonol G, an arborinane-type triterpenoid from Rubia yunnanensis. J Ethnopharmacol. 2018;220:220-227 pubmed publisher
Zhang B, Liu Y, Liu D, Yang L. Targeting cleavage and polyadenylation specific factor 1 via shRNA inhibits cell proliferation in human ovarian cancer. J Biosci. 2017;42:417-425 pubmed
Pan J, Xu Y, Song H, Zhou X, Yao Z, Ji G. Extracts of Zuo Jin Wan, a traditional Chinese medicine, phenocopies 5-HTR1D antagonist in attenuating Wnt/?-catenin signaling in colorectal cancer cells. BMC Complement Altern Med. 2017;17:506 pubmed publisher
Ruibin J, Bo J, Danying W, Chihong Z, Jianguo F, Linhui G. Therapy Effects of Wogonin on Ovarian Cancer Cells. Biomed Res Int. 2017;2017:9381513 pubmed publisher
Zhang T, Chen L, Zhang S, Xu Y, Fan Y, Zhang L. Effects of high-intensity focused ultrasound on cisplatin-resistant human lung adenocarcinoma in vitro and in vivo. Acta Biochim Biophys Sin (Shanghai). 2017;49:1092-1098 pubmed publisher
Zhou H, Zheng L, Lu K, Gao Y, Guo L, Xu W, et al. Downregulation of Cohesin Loading Factor Nipped-B-Like Protein (NIPBL) Induces Cell Cycle Arrest, Apoptosis, and Autophagy of Breast Cancer Cell Lines. Med Sci Monit. 2017;23:4817-4825 pubmed
Chen S, Guan X, Wang L, Li B, Sang X, Liu Y, et al. Fascaplysin inhibit ovarian cancer cell proliferation and metastasis through inhibiting CDK4. Gene. 2017;635:3-8 pubmed publisher
Chong D, Ma L, Liu F, Zhang Z, Zhao S, Huo Q, et al. Synergistic antitumor effect of 3-bromopyruvate and 5-fluorouracil against human colorectal cancer through cell cycle arrest and induction of apoptosis. Anticancer Drugs. 2017;28:831-840 pubmed publisher
Hu W, Wei H, Li K, Li P, Lin J, Feng R. Downregulation of USP32 inhibits cell proliferation, migration and invasion in human small cell lung cancer. Cell Prolif. 2017;50: pubmed publisher
Chen M, Lv J, Ye J, Cui X, Qu F, Chen L, et al. Disruption of serine/threonine protein phosphatase 5 inhibits tumorigenesis of urinary bladder cancer cells. Int J Oncol. 2017;51:39-48 pubmed publisher
He S, Zhong W, Yin L, Wang Y, Qiu Z, Song G. High expression of ubiquitin-specific peptidase 39 is associated with the development of vascular remodeling. Mol Med Rep. 2017;15:2567-2573 pubmed publisher
Qin C, Ren L, Ji M, Lv S, Wei Y, Zhu D, et al. CDKL1 promotes tumor proliferation and invasion in colorectal cancer. Onco Targets Ther. 2017;10:1613-1624 pubmed publisher
Huang T, Xiao Y, Yi L, Li L, Wang M, Tian C, et al. Coptisine from Rhizoma Coptidis Suppresses HCT-116 Cells-related Tumor Growth in vitro and in vivo. Sci Rep. 2017;7:38524 pubmed publisher
Zhou Y, Wang K, Zhen S, Wang R, Luo W. Carfilzomib induces G2/M cell cycle arrest in human endometrial cancer cells via upregulation of p21Waf1/Cip1 and p27Kip1. Taiwan J Obstet Gynecol. 2016;55:847-851 pubmed publisher
Yang J, Qiao L, Zeng Z, Wang J, Zhu T, Wei J, et al. The role of the ATM/Chk/P53 pathway in mediating DNA damage in hand-foot syndrome induced by PLD. Toxicol Lett. 2017;265:131-139 pubmed publisher
Wang X, Liang Z, Xu X, Li J, Zhu Y, Meng S, et al. miR-148a-3p represses proliferation and EMT by establishing regulatory circuits between ERBB3/AKT2/c-myc and DNMT1 in bladder cancer. Cell Death Dis. 2016;7:e2503 pubmed publisher
Zhao Y, Huan M, Liu M, Cheng Y, Sun Y, Cui H, et al. Doxorubicin and resveratrol co-delivery nanoparticle to overcome doxorubicin resistance. Sci Rep. 2016;6:35267 pubmed publisher
Wang Y, Zhang X, Xie W, Zheng Y, Cao J, Cao P, et al. The Growth of SGC-7901 Tumor Xenografts Was Suppressed by Chinese Bayberry Anthocyanin Extract through Upregulating KLF6 Gene Expression. Nutrients. 2016;8: pubmed
Zhang Z, Li H, Zhou C, Li Q, Ma L, Zhang Z, et al. Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells. J Exp Clin Cancer Res. 2016;35:149 pubmed
Xu S, Wang H, Pan H, Shi Y, Li T, Ge S, et al. ANRIL lncRNA triggers efficient therapeutic efficacy by reprogramming the aberrant INK4-hub in melanoma. Cancer Lett. 2016;381:41-8 pubmed publisher
Wang J, Wan X, Gao Y, Zhong M, Sha L, Liu B, et al. Latcripin-13 domain induces apoptosis and cell cycle arrest at the G1 phase in human lung carcinoma A549 cells. Oncol Rep. 2016;36:441-7 pubmed publisher
Zheng Z, Xu H, Suo S, Xu X, Ni M, Gu L, et al. The Essential Role of H19 Contributing to Cisplatin Resistance by Regulating Glutathione Metabolism in High-Grade Serous Ovarian Cancer. Sci Rep. 2016;6:26093 pubmed publisher
Fei Z, Gao Y, Qiu M, Qi X, Dai Y, Wang S, et al. Down-regulation of dihydrofolate reductase inhibits the growth of endothelial EA.hy926 cell through induction of G1 cell cycle arrest via up-regulating p53 and p21(waf1/cip1) expression. J Clin Biochem Nutr. 2016;58:105-13 pubmed publisher
Feng T, Shao F, Wu Q, Zhang X, Xu D, Qian K, et al. miR-124 downregulation leads to breast cancer progression via LncRNA-MALAT1 regulation and CDK4/E2F1 signal activation. Oncotarget. 2016;7:16205-16 pubmed publisher
Yin J, Sheng B, Han B, Pu A, Yang K, Li P, et al. The AhR is involved in the regulation of LoVo cell proliferation through cell cycle-associated proteins. Cell Biol Int. 2016;40:560-8 pubmed publisher
Song X, Li L, Shi Q, Lehmler H, Fu J, Su C, et al. Polychlorinated Biphenyl Quinone Metabolite Promotes p53-Dependent DNA Damage Checkpoint Activation, S-Phase Cycle Arrest and Extrinsic Apoptosis in Human Liver Hepatocellular Carcinoma HepG2 Cells. Chem Res Toxicol. 2015;28:2160-9 pubmed publisher
He K, Tong D, Zhang S, Cai D, Wang L, Yang Y, et al. miRNA-99b-3p functions as a potential tumor suppressor by targeting glycogen synthase kinase-3β in oral squamous cell carcinoma Tca-8113 cells. Int J Oncol. 2015;47:1528-36 pubmed publisher
He Y, Tang D, Cai C, Chai R, Li H. LSD1 is Required for Hair Cell Regeneration in Zebrafish. Mol Neurobiol. 2016;53:2421-34 pubmed publisher
Li H, Zhou F, Du W, Dou J, Xu Y, Gao W, et al. Knockdown of asparagine synthetase by RNAi suppresses cell growth in human melanoma cells and epidermoid carcinoma cells. Biotechnol Appl Biochem. 2016;63:328-33 pubmed publisher
Meng D, Chen Y, Yun D, Zhao Y, Wang J, Xu T, et al. High expression of N-myc (and STAT) interactor predicts poor prognosis and promotes tumor growth in human glioblastoma. Oncotarget. 2015;6:4901-19 pubmed
Xiao W, Jiang Y, Men Q, Yuan L, Huang Z, Liu T, et al. Tetrandrine induces G1/S cell cycle arrest through the ROS/Akt pathway in EOMA cells and inhibits angiogenesis in vivo. Int J Oncol. 2015;46:360-8 pubmed publisher
product information
CatalogNo :
11026-1-AP
AntigenName :
CDK4
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
cyclin-dependent kinase 4
Immunogen :
Recombinant Protein
Species :
canine, human, mouse, rat, zebrafish
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, FC, CoIP, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
CDK4, Cell division protein kinase 4, CMM3, cyclin dependent kinase 4, PSK J3
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC010153
Category :
Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;Metabolism;Signal transduction;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
FC 1:0 ; IF 1:50 ; IHC 1:300 ; IP 1:1000 ; WB 1:3000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.