This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
FIS1
catalog :
10956-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 67
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig s2e
Rusilowicz Jones E, Jardine J, Kallinos A, Pinto Fernandez A, Guenther F, Giurrandino M, et al. USP30 sets a trigger threshold for PINK1-PARKIN amplification of mitochondrial ubiquitylation. Life Sci Alliance. 2020;3: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s7e
Keckesova Z, Donaher J, De Cock J, Freinkman E, Lingrell S, Bachovchin D, et al. LACTB is a tumour suppressor that modulates lipid metabolism and cell state. Nature. 2017;543:681-686 pubmed publisher
  • western blot; mouse; fig s2
Korwitz A, Merkwirth C, Richter Dennerlein R, Tröder S, Sprenger H, Quirós P, et al. Loss of OMA1 delays neurodegeneration by preventing stress-induced OPA1 processing in mitochondria. J Cell Biol. 2016;212:157-66 pubmed publisher
  • western blot; mouse; fig 4
Sharoar M, Shi Q, Ge Y, He W, Hu X, Perry G, et al. Dysfunctional tubular endoplasmic reticulum constitutes a pathological feature of Alzheimer's disease. Mol Psychiatry. 2016;21:1263-71 pubmed publisher
Ma D, Zheng B, Liu H, Zhao Y, Liu X, Zhang X, et al. Klf5 down-regulation induces vascular senescence through eIF5a depletion and mitochondrial fission. PLoS Biol. 2020;18:e3000808 pubmed publisher
Mou J, Xu J, Wang Z, Wang C, Yang X, Wang X, et al. Effects of photoperiod on morphology and function in testis and epididymis of Cricetulus barabensis. J Cell Physiol. 2020;: pubmed publisher
Chen K, Wang H, Jiang L, Qian Y, Yang C, Chang W, et al. Heat stress induces apoptosis through disruption of dynamic mitochondrial networks in dairy cow mammary epithelial cells. In Vitro Cell Dev Biol Anim. 2020;56:322-331 pubmed publisher
Sun Y, Lu F, Yu X, Wang B, Chen J, Lu F, et al. Exogenous H2S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice. Aging Dis. 2020;11:269-285 pubmed publisher
Yao X, Yu S, Jing X, Guo J, Sun K, Guo F, et al. PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway. Stem Cell Res Ther. 2020;11:140 pubmed publisher
Deng X, Liu J, Liu L, Sun X, Huang J, Dong J. Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway. Int J Biol Sci. 2020;16:1403-1416 pubmed publisher
Guo J, Ren R, Yao X, Ye Y, Sun K, Lin J, et al. PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission. Aging (Albany NY). 2020;12:3976-3992 pubmed publisher
Yoo S, Yamashita S, Kim H, Na D, Lee H, Kim S, et al. FKBP8 LIRL-dependent mitochondrial fragmentation facilitates mitophagy under stress conditions. FASEB J. 2020;34:2944-2957 pubmed publisher
Zhang C, Wang J, Zhu J, Chen Y, Han X. Microcystin-leucine-arginine induced neurotoxicity by initiating mitochondrial fission in hippocampal neurons. Sci Total Environ. 2020;703:134702 pubmed publisher
Mo Y, Deng S, Zhang L, Huang Y, Li W, Peng Q, et al. SS-31 reduces inflammation and oxidative stress through the inhibition of Fis1 expression in lipopolysaccharide-stimulated microglia. Biochem Biophys Res Commun. 2019;520:171-178 pubmed publisher
Yuan J, Chen C, Cui J, Lu J, Yan C, Wei X, et al. Fatty Liver Disease Caused by High-Alcohol-Producing Klebsiella pneumoniae. Cell Metab. 2019;30:675-688.e7 pubmed publisher
Chao T, Gómez B, Heard T, Smith B, Dubick M, Burmeister D. Burn-induced reductions in mitochondrial abundance and efficiency are more pronounced with small volumes of colloids in swine. Am J Physiol Cell Physiol. 2019;317:C1229-C1238 pubmed publisher
Miao X, Li W, Niu B, Li J, Sun J, Qin M, et al. Mitochondrial dysfunction in endothelial cells induced by airborne fine particulate matter (<2.5 μm). J Appl Toxicol. 2019;: pubmed publisher
Zeng Y, Pan Q, Wang X, Li D, Lin Y, Man F, et al. Impaired Mitochondrial Fusion and Oxidative Phosphorylation Triggered by High Glucose Is Mediated by Tom22 in Endothelial Cells. Oxid Med Cell Longev. 2019;2019:4508762 pubmed publisher
Chai N, Zhang H, Li L, Yu X, Liu Y, Lin Y, et al. Spermidine Prevents Heart Injury in Neonatal Rats Exposed to Intrauterine Hypoxia by Inhibiting Oxidative Stress and Mitochondrial Fragmentation. Oxid Med Cell Longev. 2019;2019:5406468 pubmed publisher
Yang Y, Zhao M, Yu X, Liu L, He X, Deng J, et al. Pyridostigmine regulates glucose metabolism and mitochondrial homeostasis to reduce myocardial vulnerability to injury in diabetic mice. Am J Physiol Endocrinol Metab. 2019;317:E312-E326 pubmed publisher
Lee L, Seager R, Nakamura Y, Wilkinson K, Henley J. Parkin-mediated ubiquitination contributes to the constitutive turnover of mitochondrial fission factor (Mff). PLoS ONE. 2019;14:e0213116 pubmed publisher
Gai C, Feng W, Qiang T, Ma H, Chai Y, Zhang S, et al. Da-Bu-Yin-Wan and Qian-Zheng-San Ameliorate Mitochondrial Dynamics in the Parkinson's Disease Cell Model Induced by MPP. Front Pharmacol. 2019;10:372 pubmed publisher
Yi X, Guo W, Shi Q, Yang Y, Zhang W, Chen X, et al. SIRT3-Dependent Mitochondrial Dynamics Remodeling Contributes to Oxidative Stress-Induced Melanocyte Degeneration in Vitiligo. Theranostics. 2019;9:1614-1633 pubmed publisher
Silva K, Ghiarone T, Schreiber K, Grant D, White T, Frisard M, et al. Angiotensin II suppresses autophagy and disrupts ultrastructural morphology and function of mitochondria in mouse skeletal muscle. J Appl Physiol (1985). 2019;126:1550-1562 pubmed publisher
Zhao Y, Sun X, Hu D, Prosdocimo D, Hoppel C, Jain M, et al. ATAD3A oligomerization causes neurodegeneration by coupling mitochondrial fragmentation and bioenergetics defects. Nat Commun. 2019;10:1371 pubmed publisher
Yao X, Jing X, Guo J, Sun K, Deng Y, Zhang Y, et al. Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways. Front Pharmacol. 2019;10:163 pubmed publisher
Chen C, Jiang X, Li Y, Yu H, Li S, Zhang Z, et al. Low-dose oral copper treatment changes the hippocampal phosphoproteomic profile and perturbs mitochondrial function in a mouse model of Alzheimer's disease. Free Radic Biol Med. 2019;135:144-156 pubmed publisher
Zhao L, Zhuang J, Wang Y, Zhou D, Zhao D, Zhu S, et al. Propofol Ameliorates H9c2 Cells Apoptosis Induced by Oxygen Glucose Deprivation and Reperfusion Injury via Inhibiting High Levels of Mitochondrial Fusion and Fission. Front Pharmacol. 2019;10:61 pubmed publisher
Zhao Q, Niu Q, Chen J, Xia T, Zhou G, Li P, et al. Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children. Arch Toxicol. 2019;93:709-726 pubmed publisher
Wang Z, Jiang S, Cao J, Liu K, Xu S, Arfat Y, et al. Novel findings on ultrastructural protection of skeletal muscle fibers during hibernation of Daurian ground squirrels: Mitochondria, nuclei, cytoskeleton, glycogen. J Cell Physiol. 2019;234:13318-13331 pubmed publisher
Chen C, Wang H, Huang C, Huang C, Lim W, Tu I, et al. Two separate functions of NME3 critical for cell survival underlie a neurodegenerative disorder. Proc Natl Acad Sci U S A. 2019;116:566-574 pubmed publisher
Zhong X, Cui P, Cai Y, Wang L, He X, Long P, et al. Mitochondrial Dynamics Is Critical for the Full Pluripotency and Embryonic Developmental Potential of Pluripotent Stem Cells. Cell Metab. 2019;29:979-992.e4 pubmed publisher
Pusec C, DE JESUS A, Khan M, Terry A, Ludvik A, Xu K, et al. Hepatic HKDC1 Expression Contributes to Liver Metabolism. Endocrinology. 2019;160:313-330 pubmed publisher
Song H, Chen M, Chen C, Cui J, Johnson C, Cheng J, et al. Proteomic Analysis and Biochemical Correlates of Mitochondrial Dysfunction after Low-Intensity Primary Blast Exposure. J Neurotrauma. 2019;36:1591-1605 pubmed publisher
Sprenger H, Wani G, Hesseling A, König T, Patron M, MacVicar T, et al. Loss of the mitochondrial i-AAA protease YME1L leads to ocular dysfunction and spinal axonopathy. EMBO Mol Med. 2019;11: pubmed publisher
Yao X, Zhang J, Jing X, Ye Y, Guo J, Sun K, et al. Fibroblast growth factor 18 exerts anti-osteoarthritic effects through PI3K-AKT signaling and mitochondrial fusion and fission. Pharmacol Res. 2019;139:314-324 pubmed publisher
Manczak M, Kandimalla R, Yin X, Reddy P. Mitochondrial division inhibitor 1 reduces dynamin-related protein 1 and mitochondrial fission activity. Hum Mol Genet. 2019;28:177-199 pubmed publisher
Li H, Ham A, Ma T, Kuo S, Kanter E, Kim D, et al. Mitochondrial dysfunction and mitophagy defect triggered by heterozygous GBA mutations. Autophagy. 2019;15:113-130 pubmed publisher
Bao F, Shi H, Gao M, Yang L, Zhou L, Zhao Q, et al. Polybrene induces neural degeneration by bidirectional Ca2+ influx-dependent mitochondrial and ER-mitochondrial dynamics. Cell Death Dis. 2018;9:966 pubmed publisher
Chen D, Li X, Zhang L, Zhu M, Gao L. A high-fat diet impairs mitochondrial biogenesis, mitochondrial dynamics, and the respiratory chain complex in rat myocardial tissues. J Cell Biochem. 2018;119:9602 pubmed publisher
Pei S, Minhajuddin M, Adane B, Khan N, Stevens B, Mack S, et al. AMPK/FIS1-Mediated Mitophagy Is Required for Self-Renewal of Human AML Stem Cells. Cell Stem Cell. 2018;23:86-100.e6 pubmed publisher
Reddy P, Yin X, Manczak M, Kumar S, Pradeepkiran J, Vijayan M, et al. Mutant APP and amyloid beta-induced defective autophagy, mitophagy, mitochondrial structural and functional changes and synaptic damage in hippocampal neurons from Alzheimer's disease. Hum Mol Genet. 2018;27:2502-2516 pubmed publisher
Manczak M, Kandimalla R, Yin X, Reddy P. Hippocampal mutant APP and amyloid beta-induced cognitive decline, dendritic spine loss, defective autophagy, mitophagy and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Hum Mol Genet. 2018;27:1332-1342 pubmed publisher
Liu J, Lee I, Feng H, Galen S, Hüttemann P, Perkins G, et al. Aerobic Exercise Preconception and During Pregnancy Enhances Oxidative Capacity in the Hindlimb Muscles of Mice Offspring. J Strength Cond Res. 2018;32:1391-1403 pubmed publisher
Syu Y, Lai H, Jiang C, Tsai H, Lin C, Lee Y. GLUT10 maintains the integrity of major arteries through regulation of redox homeostasis and mitochondrial function. Hum Mol Genet. 2018;27:307-321 pubmed publisher
Chakrabarti R, Ji W, Stan R, de Juan Sanz J, Ryan T, Higgs H. INF2-mediated actin polymerization at the ER stimulates mitochondrial calcium uptake, inner membrane constriction, and division. J Cell Biol. 2018;217:251-268 pubmed publisher
Kandimalla R, Manczak M, Yin X, Wang R, Reddy P. Hippocampal phosphorylated tau induced cognitive decline, dendritic spine loss and mitochondrial abnormalities in a mouse model of Alzheimer's disease. Hum Mol Genet. 2018;27:30-40 pubmed publisher
Ji W, Chakrabarti R, Fan X, Schoenfeld L, Strack S, Higgs H. Receptor-mediated Drp1 oligomerization on endoplasmic reticulum. J Cell Biol. 2017;216:4123-4139 pubmed publisher
Liu N, Wu J, Zhang L, Gao Z, Sun Y, Yu M, et al. Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate. J Cell Mol Med. 2017;21:3190-3203 pubmed publisher
Xiao B, Deng X, Lim G, Zhou W, Saw W, Zhou Z, et al. p62-Mediated mitochondrial clustering attenuates apoptosis induced by mitochondrial depolarization. Biochim Biophys Acta Mol Cell Res. 2017;1864:1308-1317 pubmed publisher
Zheng X, Chen M, Meng X, Chu X, Cai C, Zou F. Phosphorylation of dynamin-related protein 1 at Ser616 regulates mitochondrial fission and is involved in mitochondrial calcium uniporter-mediated neutrophil polarization and chemotaxis. Mol Immunol. 2017;87:23-32 pubmed publisher
Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, et al. Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission. EMBO J. 2017;36:1330-1347 pubmed publisher
Wang Y, Zhao W, Li G, Chen J, Guan X, Chen X, et al. Neuroprotective Effect and Mechanism of Thiazolidinedione on Dopaminergic Neurons In Vivo and In Vitro in Parkinson's Disease. PPAR Res. 2017;2017:4089214 pubmed publisher
Guedouari H, Daigle T, Scorrano L, Hébert Chatelain E. Sirtuin 5 protects mitochondria from fragmentation and degradation during starvation. Biochim Biophys Acta Mol Cell Res. 2017;1864:169-176 pubmed publisher
Tian L, Neuber Hess M, Mewburn J, Dasgupta A, Dunham Snary K, Wu D, et al. Ischemia-induced Drp1 and Fis1-mediated mitochondrial fission and right ventricular dysfunction in pulmonary hypertension. J Mol Med (Berl). 2017;95:381-393 pubmed publisher
Liu Y, Hu Y, E Q, Zuo J, Yang L, Liu W. Salvianolic acid B inhibits mitochondrial dysfunction by up-regulating mortalin. Sci Rep. 2017;7:43097 pubmed publisher
Xu L, Shen Y, Wang X, Wei L, Wang P, Yang H, et al. Mitochondrial dynamics changes with age in an APPsw/PS1dE9 mouse model of Alzheimer's disease. Neuroreport. 2017;28:222-228 pubmed publisher
Wu H, Wang Y, Wu C, Yang P, Li H, Li Z. Resveratrol Induces Cancer Cell Apoptosis through MiR-326/PKM2-Mediated ER Stress and Mitochondrial Fission. J Agric Food Chem. 2016;64:9356-9367 pubmed
Lu Y, Wang R, Dong Y, Tucker D, Zhao N, Ahmed M, et al. Low-level laser therapy for beta amyloid toxicity in rat hippocampus. Neurobiol Aging. 2017;49:165-182 pubmed publisher
Jugé R, Breugnot J, Da Silva C, Bordes S, Closs B, Aouacheria A. Quantification and Characterization of UVB-Induced Mitochondrial Fragmentation in Normal Primary Human Keratinocytes. Sci Rep. 2016;6:35065 pubmed publisher
Manczak M, Kandimalla R, Fry D, Sesaki H, Reddy P. Protective effects of reduced dynamin-related protein 1 against amyloid beta-induced mitochondrial dysfunction and synaptic damage in Alzheimer's disease. Hum Mol Genet. 2016;25:5148-5166 pubmed publisher
Wu W, Lin C, Wu K, Jiang L, Wang X, Li W, et al. FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions. EMBO J. 2016;35:1368-84 pubmed publisher
Zhao F, Fang F, Qiao P, Yan N, Gao D, Yan Y. AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer's Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons. Oxid Med Cell Longev. 2016;2016:8360738 pubmed publisher
Ju J, Jeon S, Park J, Lee J, Lee S, Cho K, et al. Autophagy plays a role in skeletal muscle mitochondrial biogenesis in an endurance exercise-trained condition. J Physiol Sci. 2016;66:417-30 pubmed publisher
Yin X, Manczak M, Reddy P. Mitochondria-targeted molecules MitoQ and SS31 reduce mutant huntingtin-induced mitochondrial toxicity and synaptic damage in Huntington's disease. Hum Mol Genet. 2016;25:1739-53 pubmed publisher
Zhang C, Shi Z, Zhang L, Zhou Z, Zheng X, Liu G, et al. Appoptosin interacts with mitochondrial outer-membrane fusion proteins and regulates mitochondrial morphology. J Cell Sci. 2016;129:994-1002 pubmed publisher
Manczak M, Reddy P. Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease. Hum Mol Genet. 2015;24:7308-25 pubmed publisher
product information
CatalogNo :
10956-1-AP
AntigenName :
FIS1
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae)
Immunogen :
Recombinant Protein
Species :
cow, hamster, human, mouse, pig, rat, squirrels, swine
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG1
Synonyms :
CGI 135, FIS1, FIS1 homolog, hFis1, TPR repeat protein 11, TTC11
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC009428
Category :
Apoptosis;Binding Proteins;Cytoskeleton/Scaffold Proteins;Membrane Proteins;Organelle Marker;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:100 ; IHC 1:200 ; IP 1:500 ; WB 1:1500 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.