This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
AMPK alpha 1
catalog :
10929-2-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 61
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 5a, 5c
Liu X, Ma F, Liu C, Zhu K, Li W, Xu Y, et al. UBE2O promotes the proliferation, EMT and stemness properties of breast cancer cells through the UBE2O/AMPKα2/mTORC1-MYC positive feedback loop. Cell Death Dis. 2020;11:10 pubmed publisher
Xie T, Wang C, Jin Y, Meng Q, Liu Q, Wu J, et al. CoenzymeQ10-Induced Activation of AMPK-YAP-OPA1 Pathway Alleviates Atherosclerosis by Improving Mitochondrial Function, Inhibiting Oxidative Stress and Promoting Energy Metabolism. Front Pharmacol. 2020;11:1034 pubmed publisher
Liu J, Hu Y, Feng Y, Jiang Y, Guo Y, Liu Y, et al. BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer. J Exp Clin Cancer Res. 2020;39:123 pubmed publisher
Chu Y, Lin W, Lin Y, Kuo W, Tseng C, Lim S, et al. COX5B-Mediated Bioenergetic Alteration Regulates Tumor Growth and Migration by Modulating AMPK-UHMK1-ERK Cascade in Hepatoma. Cancers (Basel). 2020;12: pubmed publisher
Feng S, Zhang L, Liu X, Li G, Zhang B, Wang Z, et al. Low levels of AMPK promote epithelial-mesenchymal transition in lung cancer primarily through HDAC4- and HDAC5-mediated metabolic reprogramming. J Cell Mol Med. 2020;: pubmed publisher
Zhou B, Qiu Y, Wu N, Chen A, Zhou H, Chen Q, et al. FNDC5 Attenuates Oxidative Stress and NLRP3 Inflammasome Activation in Vascular Smooth Muscle Cells via Activating the AMPK-SIRT1 Signal Pathway. Oxid Med Cell Longev. 2020;2020:6384803 pubmed publisher
Wu H, Sun H, He Z, Chen X, Li Y, Zhao X, et al. The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models. Exp Cell Res. 2020;394:112093 pubmed publisher
Jiang X, Ruan X, Xue Y, Yang S, Shi M, Wang L. Metformin Reduces the Senescence of Renal Tubular Epithelial Cells in Diabetic Nephropathy via the MBNL1/miR-130a-3p/STAT3 Pathway. Oxid Med Cell Longev. 2020;2020:8708236 pubmed publisher
Okubo K, Isono M, Miyai K, Asano T, Sato A. Fluvastatin potentiates anticancer activity of vorinostat in renal cancer cells. Cancer Sci. 2020;111:112-126 pubmed publisher
Ye W, Wang J, Lin D, Ding Z. The immunomodulatory role of irisin on osteogenesis via AMPK-mediated macrophage polarization. Int J Biol Macromol. 2019;146:25-35 pubmed publisher
Wang C, Le Y, Lu D, Zhao M, Dou X, Zhang Q. Triphenyl phosphate causes a sexually dimorphic metabolism dysfunction associated with disordered adiponectin receptors in pubertal mice. J Hazard Mater. 2019;:121732 pubmed publisher
Han X, Zhang Y, Guo J, You Y, Zhan J, Huang W. Chlorogenic Acid Stimulates the Thermogenesis of Brown Adipocytes by Promoting the Uptake of Glucose and the Function of Mitochondria. J Food Sci. 2019;84:3815-3824 pubmed publisher
Okubo K, Isono M, Asano T, Sato A. Lopinavir-Ritonavir Combination Induces Endoplasmic Reticulum Stress and Kills Urological Cancer Cells. Anticancer Res. 2019;39:5891-5901 pubmed publisher
Meng Z, Liu Q, Sun F, Qiao L. Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling. Lipids Health Dis. 2019;18:191 pubmed publisher
Lu J, Meng Z, Cheng B, Liu M, Tao S, Guan S. Apigenin reduces the excessive accumulation of lipids induced by palmitic acid via the AMPK signaling pathway in HepG2 cells. Exp Ther Med. 2019;18:2965-2971 pubmed publisher
Wang H, Zhong P, Sun L. Exogenous hydrogen sulfide mitigates NLRP3 inflammasome-mediated inflammation through promoting autophagy via the AMPK-mTOR pathway. Biol Open. 2019;8: pubmed publisher
Sun J, Liu Y, Yu J, Wu J, Gao W, Ran L, et al. Effects of APS Activates Hepatic Insulin Signaling in HFD-induced IR Mice. J Mol Endocrinol. 2019;: pubmed publisher
Chen C, Jiang L, Zhang M, Pan X, Peng C, Huang W, et al. Isodunnianol alleviates doxorubicin-induced myocardial injury by activating protective autophagy. Food Funct. 2019;10:2651-2657 pubmed publisher
Yang Y, Zhu G, Dong B, Piao J, Chen L, Lin Z. The NQO1/PKLR axis promotes lymph node metastasis and breast cancer progression by modulating glycolytic reprogramming. Cancer Lett. 2019;453:170-183 pubmed publisher
Li S, Huang Q, Zhang L, Qiao X, Zhang Y, Tang F, et al. Effect of CAPE-pNO2 against type 2 diabetes mellitus via the AMPK/GLUT4/ GSK3β/PPARα pathway in HFD/STZ-induced diabetic mice. Eur J Pharmacol. 2019;853:1-10 pubmed publisher
Ma W, Sun X, Wang Y, Zhu Y, Han X, Liu N. Restoring mitochondrial biogenesis with metformin attenuates β-GP-induced phenotypic transformation of VSMCs into an osteogenic phenotype via inhibition of PDK4/oxidative stress-mediated apoptosis. Mol Cell Endocrinol. 2019;479:39-53 pubmed publisher
Fang J, Zhu Y, Wang H, Cao B, Fei M, Niu W, et al. Baicalin Protects Mice Brain From Apoptosis in Traumatic Brain Injury Model Through Activation of Autophagy. Front Neurosci. 2018;12:1006 pubmed publisher
Gao J, Xiong R, Xiong D, Zhao W, Zhang S, Yin T, et al. The Adenosine Monophosphate (AMP) Analog, 5-Aminoimidazole-4-Carboxamide Ribonucleotide (AICAR) Inhibits Hepatosteatosis and Liver Tumorigenesis in a High-Fat Diet Murine Model Treated with Diethylnitrosamine (DEN). Med Sci Monit. 2018;24:8533-8543 pubmed publisher
Gu S, Hua H, Guo X, Jia Z, Zhang Y, Maslov L, et al. PGC-1α Participates in the Protective Effect of Chronic Intermittent Hypobaric Hypoxia on Cardiomyocytes. Cell Physiol Biochem. 2018;50:1891-1902 pubmed publisher
Lee H, Lee S, Lee M, Son Y, Kim S, An W. Effect of Omega-3 Fatty Acid on STAMP2 Expression in the Heart and Kidney of 5/6 Nephrectomy Rat Model. Mar Drugs. 2018;16: pubmed publisher
Wang D, Lao L, Pang X, Qiao Q, Pang L, Feng Z, et al. Asiatic acid from Potentilla chinensis alleviates non-alcoholic fatty liver by regulating endoplasmic reticulum stress and lipid metabolism. Int Immunopharmacol. 2018;65:256-267 pubmed publisher
Cheng B, Lu J, Li T, Meng Z, Liu M, Sun M, et al. 1,3-Dichloro-2-Propanol inhibits autophagy via P53/AMPK/mTOR pathway in HepG2 cells. Food Chem Toxicol. 2018;122:143-150 pubmed publisher
Dai J, Huang Q, Niu K, Wang B, Li Y, Dai C, et al. Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma. Cancer Med. 2018;7:5691-5703 pubmed publisher
Okubo K, Isono M, Asano T, Sato A. Panobinostat and Nelfinavir Inhibit Renal Cancer Growth by Inducing Endoplasmic Reticulum Stress. Anticancer Res. 2018;38:5615-5626 pubmed publisher
Cao S, Yu S, Cheng L, Yan J, Zhu Y, Deng Y, et al. 9-O-benzoyl-substituted berberine exerts a triglyceride-lowering effect through AMPK signaling pathway in human hepatoma HepG2 cells. Environ Toxicol Pharmacol. 2018;64:11-17 pubmed publisher
Chen Y, Wei L, Zhang X, Liu X, Chen Y, Zhang S, et al. 3‑Bromopyruvate sensitizes human breast cancer cells to TRAIL‑induced apoptosis via the phosphorylated AMPK‑mediated upregulation of DR5. Oncol Rep. 2018;40:2435-2444 pubmed publisher
Zhang J, Zhang Q, Chen X, Liu Y, Xue J, Dahan A, et al. Revealing Synergistic Mechanism of Multiple Components in Gandi Capsule for Diabetic Nephropathy Therapeutics by Network Pharmacology. Evid Based Complement Alternat Med. 2018;2018:6503126 pubmed publisher
Isono M, Sato A, Asano T, Okubo K, Asano T. Delanzomib Interacts with Ritonavir Synergistically to Cause Endoplasmic Reticulum Stress in Renal Cancer Cells. Anticancer Res. 2018;38:3493-3500 pubmed publisher
Luo X, Wang D, Zhu X, Wang G, You Y, Ning Z, et al. Autophagic degradation of caveolin-1 promotes liver sinusoidal endothelial cells defenestration. Cell Death Dis. 2018;9:576 pubmed publisher
Zeng N, Huang R, Li N, Jiang H, Li R, Wang F, et al. MiR-451a attenuates free fatty acids-mediated hepatocyte steatosis by targeting the thyroid hormone responsive spot 14 gene. Mol Cell Endocrinol. 2018;474:260-271 pubmed publisher
Liu J, Zhang L, Yao J, Yao S, Yuan T. AMPK alleviates endoplasmic reticulum stress by inducing the ER-chaperone ORP150 via FOXO1 to protect human bronchial cells from apoptosis. Biochem Biophys Res Commun. 2018;497:564-570 pubmed publisher
Cao M, Fang J, Wang X, Wang Y, Duan K, Ye F, et al. Activation of AMP-activated protein kinase (AMPK) aggravated postoperative cognitive dysfunction and pathogenesis in aged rats. Brain Res. 2018;1684:21-29 pubmed publisher
Li C, Sun J, Gao Y, Shi F, Pan Y, Wang Y, et al. Clinorotation-induced autophagy via HDM2-p53-mTOR pathway enhances cell migration in vascular endothelial cells. Cell Death Dis. 2018;9:147 pubmed publisher
Yan J, Wang C, Jin Y, Meng Q, Liu Q, Liu Z, et al. Catalpol ameliorates hepatic insulin resistance in type 2 diabetes through acting on AMPK/NOX4/PI3K/AKT pathway. Pharmacol Res. 2018;130:466-480 pubmed publisher
Cheng G, Li B, Sun X, Cao Z, Zhang G, Zhao Z, et al. LncRNA LOC730101 promotes osteosarcoma cell survival under energy stress. Biochem Biophys Res Commun. 2018;496:1-6 pubmed publisher
Zhao Y, Shi X, Ding C, Feng D, Li Y, Hu Y, et al. Carnosic acid prevents COL1A2 transcription through the reduction of Smad3 acetylation via the AMPK?1/SIRT1 pathway. Toxicol Appl Pharmacol. 2018;339:172-180 pubmed publisher
Guo X, Sinclair A, Kaur G, Li D. Differential effects of EPA, DPA and DHA on cardio-metabolic risk factors in high-fat diet fed mice. Prostaglandins Leukot Essent Fatty Acids. 2018;136:47-55 pubmed publisher
Zheng L, Yin L, Xu L, Qi Y, Li H, Xu Y, et al. Protective effect of dioscin against thioacetamide-induced acute liver injury via FXR/AMPK signaling pathway in vivo. Biomed Pharmacother. 2018;97:481-488 pubmed publisher
Zhou Y, Wang S, Li Y, Yu S, Zhao Y. SIRT1/PGC-1α Signaling Promotes Mitochondrial Functional Recovery and Reduces Apoptosis after Intracerebral Hemorrhage in Rats. Front Mol Neurosci. 2017;10:443 pubmed publisher
Dun Y, Liu S, Zhang W, Xie M, Qiu L. Exercise Combined with Rhodiola sacra Supplementation Improves Exercise Capacity and Ameliorates Exhaustive Exercise-Induced Muscle Damage through Enhancement of Mitochondrial Quality Control. Oxid Med Cell Longev. 2017;2017:8024857 pubmed publisher
Li M, Jin C, Xu M, Zhou L, Li D, Yin Y. Bifunctional enzyme ATIC promotes propagation of hepatocellular carcinoma by regulating AMPK-mTOR-S6 K1 signaling. Cell Commun Signal. 2017;15:52 pubmed publisher
Song L, Wang Z, Wang Y, Guo D, Yang J, Chen L, et al. Natural Cyclopeptide RA-XII, a New Autophagy Inhibitor, Suppresses Protective Autophagy for Enhancing Apoptosis through AMPK/mTOR/P70S6K Pathways in HepG2 Cells. Molecules. 2017;22: pubmed publisher
Li D, Ye F, Ouyang W, Wang Y. AMP-activated protein kinase and cAMP response element-binding protein activity are associated with distinct postoperative behavioral changes in rats. J Anesth. 2017;31:806-812 pubmed publisher
Luo X, Dan Wang -, Luo X, Zhu X, Wang G, Ning Z, et al. Caveolin 1-related autophagy initiated by aldosterone-induced oxidation promotes liver sinusoidal endothelial cells defenestration. Redox Biol. 2017;13:508-521 pubmed publisher
Ran G, Ying L, Li L, Yan Q, Yi W, Ying C, et al. Resveratrol ameliorates diet-induced dysregulation of lipid metabolism in zebrafish (Danio rerio). PLoS ONE. 2017;12:e0180865 pubmed publisher
Zhou S, Lu W, Chen L, Ge Q, Chen D, Xu Z, et al. AMPK deficiency in chondrocytes accelerated the progression of instability-induced and ageing-associated osteoarthritis in adult mice. Sci Rep. 2017;7:43245 pubmed publisher
La X, Zhang L, Li Z, Yang P, Wang Y. Berberine-induced autophagic cell death by elevating GRP78 levels in cancer cells. Oncotarget. 2017;8:20909-20924 pubmed publisher
Yang Y, Zhu B, Zheng F, Li Y, Zhang Y, Hu Y, et al. Chronic metformin treatment facilitates seizure termination. Biochem Biophys Res Commun. 2017;484:450-455 pubmed publisher
Dong K, Wu M, Liu X, Huang Y, Zhang D, Wang Y, et al. Glutaredoxins concomitant with optimal ROS activate AMPK through S-glutathionylation to improve glucose metabolism in type 2 diabetes. Free Radic Biol Med. 2016;101:334-347 pubmed publisher
Liu L, Pan Y, Song Y, Su X, Ke R, Yang L, et al. Activation of AMPK ?2 inhibits airway smooth muscle cells proliferation. Eur J Pharmacol. 2016;791:235-243 pubmed publisher
Li L, Xiao L, Hou Y, He Q, Zhu J, Li Y, et al. Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats. Sci Rep. 2016;6:30272 pubmed publisher
Ke R, Liu L, Zhu Y, Li S, Xie X, Li F, et al. Knockdown of AMPK?2 Promotes Pulmonary Arterial Smooth Muscle Cells Proliferation via mTOR/Skp2/p27(Kip1) Signaling Pathway. Int J Mol Sci. 2016;17: pubmed publisher
Liu J, Wu J, Sun A, Sun Y, Yu X, Liu N, et al. Hydrogen sulfide decreases high glucose/palmitate-induced autophagy in endothelial cells by the Nrf2-ROS-AMPK signaling pathway. Cell Biosci. 2016;6:33 pubmed publisher
Liu Q, Yuan W, Tong D, Liu G, Lan W, Zhang D, et al. Metformin represses bladder cancer progression by inhibiting stem cell repopulation via COX2/PGE2/STAT3 axis. Oncotarget. 2016;7:28235-46 pubmed publisher
Ye X, Zhang Y, He B, Meng Y, Li Y, Gao Y. Quantitative proteomic analysis identifies new effectors of FOXM1 involved in breast cancer cell migration. Int J Clin Exp Pathol. 2015;8:15836-44 pubmed
Xia C, Zhu L, Shao W, Mi S, Du S, Ye L, et al. The Effect of Hippocampal Cognitive Impairment and XIAP on Glucose and Lipids Metabolism in Rats. Cell Physiol Biochem. 2016;38:609-18 pubmed publisher
product information
CatalogNo :
10929-2-AP
AntigenName :
AMPK alpha 1
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
protein kinase, AMP-activated, alpha 1 catalytic subunit
Immunogen :
Recombinant Protein
Species :
human, mouse, rat, zebrafish
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
AMPK, AMPK alpha, AMPK alpha 1, AMPK subunit alpha 1, AMPK1, AMPKa1, PRKAA1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC012622
Category :
Binding Proteins;Immunology;Metabolism;Signal transduction;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IHC 1:200 ; WB 1:300 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.