alpha-synuclein | Proteintech Group 10842-1-AP product information

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product summary

company name :

Proteintech Group

product type :

antibody

product name :

alpha-synuclein

catalog :

10842-1-AP

quantity :

150UL

price :

299 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

citations: 19

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:100; loading ...; fig 1f	Kakimoto Y, Sasaki A, Niioka M, Kawabe N, Osawa M. Myocardial cathepsin D is downregulated in sudden cardiac death. PLoS ONE. 2020;15:e0230375 pubmed publisher
	Mao K, Chen J, Yu H, Li H, Ren Y, Wu X, et al. Poly (ADP-ribose) polymerase 1 inhibition prevents neurodegeneration and promotes α-synuclein degradation via transcription factor EB-dependent autophagy in mutant α-synucleinA53T model of Parkinson's disease. Aging Cell. 2020;19:e13163 pubmed publisher
	Chadchankar J, Korboukh V, Conway L, Wobst H, Walker C, Doig P, et al. Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells. PLoS ONE. 2019;14:e0225145 pubmed publisher
	Chiu C, Yeh T, Chen R, Chen H, Huang Y, Weng Y, et al. Upregulated Expression of MicroRNA-204-5p Leads to the Death of Dopaminergic Cells by Targeting DYRK1A-Mediated Apoptotic Signaling Cascade. Front Cell Neurosci. 2019;13:399 pubmed publisher
	So L, Munger S, Miller J. Social context-dependent singing alters molecular markers of dopaminergic and glutamatergic signaling in finch basal ganglia Area X. Behav Brain Res. 2019;360:103-112 pubmed publisher
	Zhou P, Homberg J, Fang Q, Wang J, Li W, Meng X, et al. Histamine-4 receptor antagonist JNJ7777120 inhibits pro-inflammatory microglia and prevents the progression of Parkinson-like pathology and behaviour in a rat model. Brain Behav Immun. 2019;76:61-73 pubmed publisher
	Chiu C, Lu C, Weng Y, Chen Y, Huang Y, Chen R, et al. PARK14 (D331Y) PLA2G6 Causes Early-Onset Degeneration of Substantia Nigra Dopaminergic Neurons by Inducing Mitochondrial Dysfunction, ER Stress, Mitophagy Impairment and Transcriptional Dysregulation in a Knockin Mouse Model. Mol Neurobiol. 2019;56:3835-3853 pubmed publisher
	Remor A, da Silva R, de Matos F, Glaser V, de Paula Martins R, Ghisoni K, et al. Chronic Metabolic Derangement-Induced Cognitive Deficits and Neurotoxicity Are Associated with REST Inactivation. Mol Neurobiol. 2019;56:1539-1557 pubmed publisher
	Su J, Wang H, Yang Y, Wang J, Li H, Huang D, et al. RESP18 deficiency has protective effects in dopaminergic neurons in an MPTP mouse model of Parkinson's disease. Neurochem Int. 2018;118:195-204 pubmed publisher
	Chen J, Ren Y, Gui C, Zhao M, Wu X, Mao K, et al. Phosphorylation of Parkin at serine 131 by p38 MAPK promotes mitochondrial dysfunction and neuronal death in mutant A53T α-synuclein model of Parkinson's disease. Cell Death Dis. 2018;9:700 pubmed publisher
	Koga S, Lin W, Walton R, Ross O, Dickson D. TDP-43 pathology in multiple system atrophy: colocalization of TDP-43 and α-synuclein in glial cytoplasmic inclusions. Neuropathol Appl Neurobiol. 2018;44:707-721 pubmed publisher
	Tayebi N, Parisiadou L, Berhe B, Gonzalez A, Serra Vinardell J, Tamargo R, et al. Glucocerebrosidase haploinsufficiency in A53T ?-synuclein mice impacts disease onset and course. Mol Genet Metab. 2017;122:198-208 pubmed publisher
	Huang C, Zhu L, Li H, Shi F, Wang G, Wei Y, et al. Adulthood Exposure to Lipopolysaccharide Exacerbates the Neurotoxic and Inflammatory Effects of Rotenone in the Substantia Nigra. Front Mol Neurosci. 2017;10:131 pubmed publisher
	Duan J, Ying Z, Su Y, Lin F, Deng Y. ?-Synuclein binds to cytoplasmic vesicles in U251 glioblastoma cells. Neurosci Lett. 2017;642:148-152 pubmed publisher
	Rodríguez Nogales C, Garbayo E, Martinez Valbuena I, Sebastian V, Luquin M, Blanco Prieto M. Development and characterization of polo-like kinase 2 loaded nanoparticles-A novel strategy for (serine-129) phosphorylation of alpha-synuclein. Int J Pharm. 2016;514:142-149 pubmed publisher
	Marques F, Tenney J, Durán I, Martin J, Nevarez L, Pogue R, et al. Altered mRNA Splicing, Chondrocyte Gene Expression and Abnormal Skeletal Development due to SF3B4 Mutations in Rodriguez Acrofacial Dysostosis. PLoS Genet. 2016;12:e1006307 pubmed publisher
	Yang W, Wang G, Wang C, Guo X, Yin P, Gao J, et al. Mutant alpha-synuclein causes age-dependent neuropathology in monkey brain. J Neurosci. 2015;35:8345-58 pubmed publisher
	Xiang W, Menges S, Schlachetzki J, Meixner H, Hoffmann A, SchlÃ¶tzer Schrehardt U, et al. Posttranslational modification and mutation of histidine 50 trigger alpha synuclein aggregation and toxicity. Mol Neurodegener. 2015;10:8 pubmed publisher
	Xiong J, Zhang X, Huang J, Chen C, Chen Z, Liu L, et al. Fenpropathrin, a Widely Used Pesticide, Causes Dopaminergic Degeneration. Mol Neurobiol. 2016;53:995-1008 pubmed publisher

product information

CatalogNo :

10842-1-AP

AntigenName :

alpha-synuclein

Package :

150UL

Price :

299 USD

Exsists20ul :

20ul trial size available

FullName :

synuclein, alpha (non A4 component of amyloid precursor)

Immunogen :

Recombinant Protein

Species :

human, mouse, rat, zebra finches

Host :

Rabbit

IsConjugated :

Unconjugated

AntigenSpecies :

human

Application :

WB, IHC, IF, ELISA

Clonlity :

Polyclonal

IsoType :

IgG

Synonyms :

Alpha synuclein, NACP, PARK1, PARK4, PD1, SNCA

PrimaryOrSecondary :

Primary

AntibodyBuffer :

PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

GenBankNo :

BC013293

Category :

Binding Proteins;Cytoskeleton/Scaffold Proteins;Disease Related;Membrane Proteins;Neurology;Transport/Trafficking;

PurifyMethod :

Antigen affinity purification

NewAb :

False

IsSellable :

True

AppTiter :

IF 1:25 ; IHC 1:200 ; WB 1:800 ;