| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunoprecipitation; human; loading ...; fig 2b
| Peng M, Yin N, Li M. SZT2 dictates GATOR control of mTORC1 signalling. Nature. 2017;543:433-437 pubmed publisher |
- western blot; mouse; fig 7
- western blot; human; fig 1
| Kimball S, Gordon B, Moyer J, Dennis M, Jefferson L. Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation. Cell Signal. 2016;28:896-906 pubmed publisher |
- western blot; human; fig 7f
| Ro S, Xue X, Ramakrishnan S, Cho C, Namkoong S, Jang I, et al. Tumor suppressive role of sestrin2 during colitis and colon carcinogenesis. elife. 2016;5:e12204 pubmed publisher |
- western blot; mouse; fig 6
- immunocytochemistry; human; 1:100; fig s3
- western blot; human; fig 6
| Agarwal S, Bell C, Taylor S, Moran R. p53 Deletion or Hotspot Mutations Enhance mTORC1 Activity by Altering Lysosomal Dynamics of TSC2 and Rheb. Mol Cancer Res. 2016;14:66-77 pubmed publisher |
| Eldad S, Hertz R, Vainer G, Saada A, Bar Tana J. Treatment of ErbB2 breast cancer by mitochondrial targeting. Cancer Metab. 2020;8:17 pubmed publisher |
| Li Y, Wu J, Yu S, Zhu J, Zhou Y, Wang P, et al. Sestrin2 promotes angiogenesis to alleviate brain injury by activating Nrf2 through regulating the interaction between p62 and Keap1 following photothrombotic stroke in rats. Brain Res. 2020;1745:146948 pubmed publisher |
| Chen M, Xi Y, Chen K, Xiao P, Li S, Sun X, et al. Upregulation Sestrin2 protects against hydrogen peroxide-induced oxidative damage bovine mammary epithelial cells via a Keap1-Nrf2/ARE pathway. J Cell Physiol. 2020;: pubmed publisher |
| Jegal K, Kim E, Kim J, Park S, Jung D, Lee G, et al. Luteolin prevents liver from tunicamycin-induced endoplasmic reticulum stress via nuclear factor erythroid 2-related factor 2-dependent sestrin 2 induction. Toxicol Appl Pharmacol. 2020;399:115036 pubmed publisher |
| Kanno A, Asahara S, Furubayashi A, Masuda K, Yoshitomi R, Suzuki E, et al. GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels. JCI Insight. 2020;5: pubmed publisher |
| Fan Y, Xing Y, Xiong L, Wang J. Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation. Chem Biol Interact. 2020;324:109086 pubmed publisher |
| Du J, He W, Zhang C, Wu J, Li Z, Wang M, et al. Pentamethylquercetin Attenuates Cardiac Remodeling via Activation of the Sestrins/Keap1/Nrf2 Pathway in MSG-Induced Obese Mice. Biomed Res Int. 2020;2020:3243906 pubmed publisher |
| Segalés J, Perdiguero E, Serrano A, Sousa Victor P, Ortet L, Jardi M, et al. Sestrin prevents atrophy of disused and aging muscles by integrating anabolic and catabolic signals. Nat Commun. 2020;11:189 pubmed publisher |
| Kowalsky A, Namkoong S, Mettetal E, Park H, Kazyken D, Fingar D, et al. The GATOR2-mTORC2 axis mediates Sestrin2-induced AKT Ser/Thr kinase activation. J Biol Chem. 2020;: pubmed publisher |
| Lee D, Park J, Lee Y, Han J, Lee D, Kwon S, et al. SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. Autophagy. 2020;:1-25 pubmed publisher |
| Xu D, Dai W, Kutzler L, Lacko H, Jefferson L, Dennis M, et al. ATF4-Mediated Upregulation of REDD1 and Sestrin2 Suppresses mTORC1 Activity during Prolonged Leucine Deprivation. J Nutr. 2019;: pubmed publisher |
| Ding B, Haidurov A, Chawla A, Parmigiani A, van de Kamp G, Dalina A, et al. p53-inducible SESTRINs might play opposite roles in the regulation of early and late stages of lung carcinogenesis. Oncotarget. 2019;10:6997-7009 pubmed publisher |
| Vivas García Y, Falletta P, Liebing J, Louphrasitthiphol P, Feng Y, Chauhan J, et al. Lineage-Restricted Regulation of SCD and Fatty Acid Saturation by MITF Controls Melanoma Phenotypic Plasticity. Mol Cell. 2019;: pubmed publisher |
| Rajanala S, Ringquist R, Cryns V. Methionine restriction activates the integrated stress response in triple-negative breast cancer cells by a GCN2- and PERK-independent mechanism. Am J Cancer Res. 2019;9:1766-1775 pubmed |
| Li W, Jiang Y, Wang Y, Zhao M, Hou G, Hu H, et al. Protective Effects of Combination of Radix Astragali and Radix Salviae Miltiorrhizae on Kidney of Spontaneously Hypertensive Rats and Renal Intrinsic Cells. Chin J Integr Med. 2019;: pubmed publisher |
| Park S, Cho S, Kim K, Yang J, Kim J, Jeong E, et al. Protective effect of sestrin2 against iron overload and ferroptosis-induced liver injury. Toxicol Appl Pharmacol. 2019;379:114665 pubmed publisher |
| Park J, Lee Y, Lee D, Bae S. Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity. Free Radic Biol Med. 2019;137:143-157 pubmed publisher |
| Li R, Huang Y, Semple I, Kim M, Zhang Z, Lee J. Cardioprotective roles of sestrin 1 and sestrin 2 against doxorubicin cardiotoxicity. Am J Physiol Heart Circ Physiol. 2019;317:H39-H48 pubmed publisher |
| Jin H, Du C, Wang C, Yuan C, Du W. Ginseng metabolite Protopanaxadiol induces Sestrin2 expression and AMPK activation through GCN2 and PERK. Cell Death Dis. 2019;10:311 pubmed publisher |
| Yang J, Kim K, Cho S, Shin S, Ka S, Na C, et al. Inhibitory Effect of Sestrin 2 on Hepatic Stellate Cell Activation and Liver Fibrosis. Antioxid Redox Signal. 2019;31:243-259 pubmed publisher |
| Xu D, Shimkus K, Lacko H, Kutzler L, Jefferson L, Kimball S. Evidence for a role for Sestrin1 in mediating leucine-induced activation of mTORC1 in skeletal muscle. Am J Physiol Endocrinol Metab. 2019;316:E817-E828 pubmed publisher |
| Xia J, Zeng W, Xia Y, Wang B, Xu D, Liu D, et al. Cold atmospheric plasma induces apoptosis of melanoma cells via Sestrin2-mediated nitric oxide synthase signaling. J Biophotonics. 2019;12:e201800046 pubmed publisher |
| Florean C, Kim K, Schnekenburger M, Kim H, Moriou C, Debitus C, et al. Synergistic AML Cell Death Induction by Marine Cytotoxin (+)-1(R), 6(S), 1'(R), 6'(S), 11(R), 17(S)-Fistularin-3 and Bcl-2 Inhibitor Venetoclax. Mar Drugs. 2018;16: pubmed publisher |
| Sundararajan S, Jayachandran I, Balasubramanyam M, Mohan V, Venkatesan B, Manickam N. Sestrin2 regulates monocyte activation through AMPK-mTOR nexus under high-glucose and dyslipidemic conditions. J Cell Biochem. 2018;: pubmed publisher |
| Shin D, Kim E, Lee J, Roh J. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018;129:454-462 pubmed publisher |
| Dai J, Huang Q, Niu K, Wang B, Li Y, Dai C, et al. Sestrin 2 confers primary resistance to sorafenib by simultaneously activating AKT and AMPK in hepatocellular carcinoma. Cancer Med. 2018;7:5691-5703 pubmed publisher |
| Zheng Y, Lei Q, Jongejan A, Mulder C, van Daalen S, Mastenbroek S, et al. The influence of retinoic acid-induced differentiation on the radiation response of male germline stem cells. DNA Repair (Amst). 2018;70:55-66 pubmed publisher |
| Wang T, Niu Y, Liu S, Yuan H, Liu X, Fu L. Exercise improves glucose uptake in murine myotubes through the AMPKα2-mediated induction of Sestrins. Biochim Biophys Acta Mol Basis Dis. 2018;1864:3368-3377 pubmed publisher |
| Zeng N, D Souza R, Sorrenson B, Merry T, Barnett M, Mitchell C, et al. The putative leucine sensor Sestrin2 is hyperphosphorylated by acute resistance exercise but not protein ingestion in human skeletal muscle. Eur J Appl Physiol. 2018;118:1241-1253 pubmed publisher |
| Jung J, Park S, Ko H, Lee J, Park C, Byun S, et al. Epimedium koreanum Ameliorates Oxidative Stress-Mediated Liver Injury by Activating Nuclear Factor Erythroid 2-Related Factor 2. Am J Chin Med. 2018;46:469-488 pubmed publisher |
| Kumar A, Shaha C. SESN2 facilitates mitophagy by helping Parkin translocation through ULK1 mediated Beclin1 phosphorylation. Sci Rep. 2018;8:615 pubmed publisher |
| Quan N, Wang L, Chen X, Luckett C, Cates C, Rousselle T, et al. Sestrin2 prevents age-related intolerance to post myocardial infarction via AMPK/PGC-1α pathway. J Mol Cell Cardiol. 2018;115:170-178 pubmed publisher |
| Kumar A, Shaha C. RBX1-mediated ubiquitination of SESN2 promotes cell death upon prolonged mitochondrial damage in SH-SY5Y neuroblastoma cells. Mol Cell Biochem. 2018;446:1-9 pubmed publisher |
| Kim J, Lee J, Jung E, Jung J, Jung D, Ku S, et al. Hemistepsin A ameliorates acute inflammation in macrophages via inhibition of nuclear factor-κB and activation of nuclear factor erythroid 2-related factor 2. Food Chem Toxicol. 2018;111:176-188 pubmed publisher |
| Zeng N, D Souza R, Figueiredo V, Markworth J, Roberts L, Peake J, et al. Acute resistance exercise induces Sestrin2 phosphorylation and p62 dephosphorylation in human skeletal muscle. Physiol Rep. 2017;5: pubmed publisher |
| Zhang C, Sun W, Li J, Xiong B, Frye M, Ding D, et al. Loss of sestrin 2 potentiates the early onset of age-related sensory cell degeneration in the cochlea. Neuroscience. 2017;361:179-191 pubmed publisher |
| Byun J, Choi Y, Kim J, Jeong J, Jeon H, Kim M, et al. A Positive Feedback Loop between Sestrin2 and mTORC2 Is Required for the Survival of Glutamine-Depleted Lung Cancer Cells. Cell Rep. 2017;20:586-599 pubmed publisher |
| Xing Y, Liu Y, Liu X, Wang S, Li P, Lin X, et al. Effects of Gui Zhu Yi Kun formula on the P53/AMPK pathway of autophagy in granulosa cells of rats with polycystic ovary syndrome. Exp Ther Med. 2017;13:3567-3573 pubmed publisher |
| Ebnoether E, Ramseier A, Cortada M, Bodmer D, Levano Huaman S. Sesn2 gene ablation enhances susceptibility to gentamicin-induced hair cell death via modulation of AMPK/mTOR signaling. Cell Death Discov. 2017;3:17024 pubmed publisher |
| Kim H, Joe Y, Kim S, Park S, Park J, Chen Y, et al. Carbon monoxide protects against hepatic steatosis in mice by inducing sestrin-2 via the PERK-eIF2?-ATF4 pathway. Free Radic Biol Med. 2017;110:81-91 pubmed publisher |
| Jegal K, Park S, Cho S, Byun S, Ku S, Kim S, et al. Activating transcription factor 6-dependent sestrin 2 induction ameliorates ER stress-mediated liver injury. Biochim Biophys Acta Mol Cell Res. 2017;1864:1295-1307 pubmed publisher |
| Li H, Liu S, Yuan H, Niu Y, Fu L. Sestrin 2 induces autophagy and attenuates insulin resistance by regulating AMPK signaling in C2C12 myotubes. Exp Cell Res. 2017;354:18-24 pubmed publisher |
| Kim S, Kim K, Yang J, Cho S, Kim J, Park S, et al. Sestrin2 protects against acetaminophen-induced liver injury. Chem Biol Interact. 2017;269:50-58 pubmed publisher |
| Seo K, Ki S, Park E, Shin S. 5-Fluorouracil inhibits cell migration by induction of Sestrin2 in colon cancer cells. Arch Pharm Res. 2017;40:231-239 pubmed publisher |
| Mlitz V, Gendronneau G, Berlin I, Buchberger M, Eckhart L, Tschachler E. The Expression of the Endogenous mTORC1 Inhibitor Sestrin 2 Is Induced by UVB and Balanced with the Expression Level of Sestrin 1. PLoS ONE. 2016;11:e0166832 pubmed publisher |
| Seo K, Seo S, Ki S, Shin S. Sestrin2 inhibits hypoxia-inducible factor-1? accumulation via AMPK-mediated prolyl hydroxylase regulation. Free Radic Biol Med. 2016;101:511-523 pubmed publisher |
| Park J, Oh S, Lee D, Lee Y, Sung S, Ji H, et al. p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death. Free Radic Res. 2016;50:1408-1421 pubmed |
| Tomasovic A, Kurrle N, Wempe F, De Zolt S, Scheibe S, Koli K, et al. Ltbp4 regulates Pdgfrβ expression via TGFβ-dependent modulation of Nrf2 transcription factor function. Matrix Biol. 2017;59:109-120 pubmed publisher |
| Zhao B, Shah P, Qiang L, He T, Budanov A, He Y. Distinct Role of Sesn2 in Response to UVB-Induced DNA Damage and UVA-Induced Oxidative Stress in Melanocytes. Photochem Photobiol. 2017;93:375-381 pubmed publisher |
| Li L, Xiao L, Hou Y, He Q, Zhu J, Li Y, et al. Sestrin2 Silencing Exacerbates Cerebral Ischemia/Reperfusion Injury by Decreasing Mitochondrial Biogenesis through the AMPK/PGC-1α Pathway in Rats. Sci Rep. 2016;6:30272 pubmed publisher |
| Kim M, Bae S, Ryu J, Kwon Y, Oh J, Kwon J, et al. SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages. Autophagy. 2016;12:1272-91 pubmed publisher |
| Seo K, Seo S, Ki S, Shin S. Compound C Increases Sestrin2 Expression via Mitochondria-Dependent ROS Production. Biol Pharm Bull. 2016;39:799-806 pubmed publisher |
| Jegal K, Ko H, Park S, Byun S, Kang K, Cho I, et al. Eupatilin induces Sestrin2-dependent autophagy to prevent oxidative stress. Apoptosis. 2016;21:642-56 pubmed publisher |
| Ding B, Parmigiani A, Divakaruni A, Archer K, Murphy A, Budanov A. Sestrin2 is induced by glucose starvation via the unfolded protein response and protects cells from non-canonical necroptotic cell death. Sci Rep. 2016;6:22538 pubmed publisher |
| Reddy K, Cusack C, Nnah I, Khayati K, Saqcena C, Huynh T, et al. Dysregulation of Nutrient Sensing and CLEARance in Presenilin Deficiency. Cell Rep. 2016;14:2166-2179 pubmed publisher |
| Sun W, Quan N, Wang L, Yang H, Chu D, Liu Q, et al. Cardiac-Specific Deletion of the Pdha1 Gene Sensitizes Heart to Toxicological Actions of Ischemic Stress. Toxicol Sci. 2016;151:193-203 pubmed publisher |
| Kim H, An S, Ro S, Teixeira F, Park G, Kim C, et al. Janus-faced Sestrin2 controls ROS and mTOR signalling through two separate functional domains. Nat Commun. 2015;6:10025 pubmed publisher |
| Ye J, Palm W, Peng M, King B, Lindsten T, Li M, et al. GCN2 sustains mTORC1 suppression upon amino acid deprivation by inducing Sestrin2. Genes Dev. 2015;29:2331-6 pubmed publisher |
| Yamani L, Li B, Larose L. Nck1 deficiency improves pancreatic β cell survival to diabetes-relevant stresses by modulating PERK activation and signaling. Cell Signal. 2015;27:2555-67 pubmed publisher |
| Kimball S, Ravi S, Gordon B, Dennis M, Jefferson L. Amino Acid-Induced Activation of mTORC1 in Rat Liver Is Attenuated by Short-Term Consumption of a High-Fat Diet. J Nutr. 2015;145:2496-502 pubmed publisher |
| Ding B, Parmigiani A, Yang C, Budanov A. Sestrin2 facilitates death receptor-induced apoptosis in lung adenocarcinoma cells through regulation of XIAP degradation. Cell Cycle. 2015;14:3231-41 pubmed publisher |
| Wu C, Chen S, Yin J, Hwang C, Yang D. Nuclear Factor-kappaB-Dependent Sestrin2 Induction Mediates the Antioxidant Effects of BDNF Against Mitochondrial Inhibition in Rat Cortical Neurons. Mol Neurobiol. 2016;53:4126-4142 pubmed publisher |
| Chai D, Wang G, Zhou Z, Yang H, Yu Z. Insulin Increases Sestrin 2 Content by Reducing Its Degradation through the PI 3 K/mTOR Signaling Pathway. Int J Endocrinol. 2015;2015:505849 pubmed publisher |
| Seo K, Ki S, Shin S. Sestrin2-AMPK activation protects mitochondrial function against glucose deprivation-induced cytotoxicity. Cell Signal. 2015;27:1533-43 pubmed publisher |
| Tomasovic A, Kurrle N, Sürün D, Heidler J, Husnjak K, Poser I, et al. Sestrin 2 protein regulates platelet-derived growth factor receptor β (Pdgfrβ) expression by modulating proteasomal and Nrf2 transcription factor functions. J Biol Chem. 2015;290:9738-52 pubmed publisher |
| Kim M, Yang J, Kim K, Jang C, Jung J, Cho I, et al. Regulation of Toll-like receptor-mediated Sestrin2 induction by AP-1, Nrf2, and the ubiquitin-proteasome system in macrophages. Toxicol Sci. 2015;144:425-35 pubmed publisher |
| Yang J, Kim K, Kim M, Seo K, Han J, Ka S, et al. Role of sestrin2 in the regulation of proinflammatory signaling in macrophages. Free Radic Biol Med. 2015;78:156-67 pubmed publisher |
| Tao R, Xiong X, Liangpunsakul S, Dong X. Sestrin 3 protein enhances hepatic insulin sensitivity by direct activation of the mTORC2-Akt signaling. Diabetes. 2015;64:1211-23 pubmed publisher |
| Morrison A, Chen L, Wang J, Zhang M, Yang H, Ma Y, et al. Sestrin2 promotes LKB1-mediated AMPK activation in the ischemic heart. FASEB J. 2015;29:408-17 pubmed publisher |
