This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
Bcl-XL
catalog :
10783-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 62
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; loading ...; fig 5c, 6e
Ju L, Shan L, Yin B, Song Y. δ-Catenin regulates proliferation and apoptosis in renal cell carcinoma via promoting β-catenin nuclear localization and activating its downstream target genes. Cancer Med. 2020;9:2201-2212 pubmed publisher
Yuan C, Yang D, Ma J, Yang J, Xue J, Song F, et al. Modulation of Wnt/β-catenin signaling in IL-17A-mediated macrophage polarization of RAW264.7 cells. Braz J Med Biol Res. 2020;53:e9488 pubmed publisher
Dong P, Fu H, Chen L, Zhang S, Zhang X, Li H, et al. PCNP promotes ovarian cancer progression by accelerating β-catenin nuclear accumulation and triggering EMT transition. J Cell Mol Med. 2020;: pubmed publisher
Yu M, Ren L, Liang F, Zhang Y, Jiang L, Ma W, et al. Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice. Phytomedicine. 2020;76:153216 pubmed publisher
Yang T, Fan T, Xu B. Norfloxacin induces apoptosis and necroptosis in human corneal epithelial cells. Toxicol In Vitro. 2020;66:104868 pubmed publisher
Su Q, Wang J, Liu F, Zhang Y. Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis. Toxicol In Vitro. 2020;66:104840 pubmed publisher
Su W, Zhao J, Fan T. Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms. Front Pharmacol. 2020;11:202 pubmed publisher
Deng X, Liu J, Liu L, Sun X, Huang J, Dong J. Drp1-mediated mitochondrial fission contributes to baicalein-induced apoptosis and autophagy in lung cancer via activation of AMPK signaling pathway. Int J Biol Sci. 2020;16:1403-1416 pubmed publisher
Jin W, Xue Y, Xue Y, Han X, Song Q, Zhang J, et al. Tannic acid ameliorates arsenic trioxide-induced nephrotoxicity, contribution of NF-κB and Nrf2 pathways. Biomed Pharmacother. 2020;126:110047 pubmed publisher
Xu B, Sui Y, Fan T. Gatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways. Int J Ophthalmol. 2019;12:1524-1530 pubmed publisher
Yang Q, Yang K, Li Z. MiR-22 restrains proliferation of rheumatoid arthritis by targeting IL6R and may be concerned with the suppression of NF-κB pathway. Kaohsiung J Med Sci. 2019;: pubmed publisher
Zhang X, Fang J, Chen S, Wang W, Meng S, Liu B. Nonconserved miR-608 suppresses prostate cancer progression through RAC2/PAK4/LIMK1 and BCL2L1/caspase-3 pathways by targeting the 3'-UTRs of RAC2/BCL2L1 and the coding region of PAK4. Cancer Med. 2019;: pubmed publisher
Zhang T, Chen H, Cao J, Xiong H, Mo X, Li T, et al. Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interaction. Nat Commun. 2019;10:3192 pubmed publisher
Wu D, Li M, Gao Y, Tian W, Li J, Zhang Q, et al. Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway. J Cancer. 2019;10:1693-1706 pubmed publisher
Cai Y, Sheng Z, Chen Y, Wang J. LncRNA HMMR-AS1 promotes proliferation and metastasis of lung adenocarcinoma by regulating MiR-138/sirt6 axis. Aging (Albany NY). 2019;11:3041-3054 pubmed publisher
Dong Q, Yang B, Han J, Zhang M, Liu W, Zhang X, et al. A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways. Cancer Lett. 2019;: pubmed publisher
Yang H, Qiu B, Chen S, Xun Y, Pan Y, Chen M, et al. Soluble CXCL16 promotes TNF-α-induced apoptosis in DLBCL via the AMAD10-NF-κB regulatory feedback loop. Cell Biol Int. 2019;: pubmed publisher
Zhang Y, Li Q, Yu S, Zhu C, Zhang Z, Cao H, et al. Long non-coding RNA FAM84B-AS promotes resistance of gastric cancer to platinum drugs through inhibition of FAM84B expression. Biochem Biophys Res Commun. 2019;: pubmed publisher
Chen L, Liu L, Xie Z, Wang F, Zhu L, Zhang C, et al. Protein kinase RNA-like ER kinase/eukaryotic translation initiation factor 2α pathway attenuates tumor necrosis factor alpha-induced apoptosis in nucleus pulposus cells by activating autophagy. J Cell Physiol. 2019;234:11631-11645 pubmed publisher
Zhao G, Li K, Chen J, Li L. Protective Effect of Extract of Bletilla Striata on Isoflurane Induced Neuronal Injury By Altering PI3K/Akt Pathway. Transl Neurosci. 2018;9:183-189 pubmed publisher
Xia X, Zhou W, Guo C, Fu Z, Zhu L, Li P, et al. Glutaminolysis Mediated by MALT1 Protease Activity Facilitates PD-L1 Expression on ABC-DLBCL Cells and Contributes to Their Immune Evasion. Front Oncol. 2018;8:632 pubmed publisher
Wang J, Li M, Cui X, Lv D, Jin L, Khan M, et al. Brevilin A promotes oxidative stress and induces mitochondrial apoptosis in U87 glioblastoma cells. Onco Targets Ther. 2018;11:7031-7040 pubmed publisher
Wang J, Li H, Wang X, Shen T, Wang S, Ren D. Alisol B-23-acetate, a tetracyclic triterpenoid isolated from Alisma orientale, induces apoptosis in human lung cancer cells via the mitochondrial pathway. Biochem Biophys Res Commun. 2018;505:1015-1021 pubmed publisher
Meng M, Chen Y, Jia J, Li L, Yang S. Knockdown of PAICS inhibits malignant proliferation of human breast cancer cell lines. Biol Res. 2018;51:24 pubmed publisher
Zhang H, Zong Y, Qiu G, Jia R, Xu X, Wang F, et al. Silencing Lin28 promotes apoptosis in colorectal cancer cells by upregulating let?7c targeting of antiapoptotic BCL2L1. Mol Med Rep. 2018;17:5143-5149 pubmed publisher
Chen S, Wang L, Sun K, Xiu Y, Zong Z, Chen X, et al. The role of the long non-coding RNA TDRG1 in epithelial ovarian carcinoma tumorigenesis and progression through miR-93/RhoC pathway. Mol Carcinog. 2018;57:225-234 pubmed publisher
Yin S, Du W, Wang F, Han B, Cui Y, Yang D, et al. MicroRNA-326 sensitizes human glioblastoma cells to curcumin via the SHH/GLI1 signaling pathway. Cancer Biol Ther. 2018;19:260-270 pubmed publisher
Wang H, Zhu L, Feng X, Zhang H, Luo Q, Chen F. Oridonin induces G2/M cell cycle arrest and apoptosis in human oral squamous cell carcinoma. Eur J Pharmacol. 2017;815:282-289 pubmed publisher
Liu Y, Zong Z, Guan X, Wang L, Zhao Y. The role of long non-coding RNA PCA3 in epithelial ovarian carcinoma tumorigenesis and progression. Gene. 2017;633:42-47 pubmed publisher
Wang L, Sun K, Wu D, Xiu Y, Chen X, Chen S, et al. DLEU1 contributes to ovarian carcinoma tumourigenesis and development by interacting with miR-490-3p and altering CDK1 expression. J Cell Mol Med. 2017;21:3055-3065 pubmed publisher
Ning C, Liang M, Liu S, Wang G, Edwards H, Xia Y, et al. Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer. Oncotarget. 2017;8:44295-44311 pubmed publisher
Zeng W, Wang Q, Chen L, Huang L, Zhao X. Anticancer effect of PP31J isolated from Physalis pubescens L. in human cervical carcinoma cells. Am J Transl Res. 2017;9:2466-2472 pubmed
Tang F, Hu P, Yang Z, Xue C, Gong J, Sun S, et al. SBI0206965, a novel inhibitor of Ulk1, suppresses non-small cell lung cancer cell growth by modulating both autophagy and apoptosis pathways. Oncol Rep. 2017;37:3449-3458 pubmed publisher
Jiang Z, Song F, Li Y, Xue D, Zhao N, Zhang J, et al. Capsular Polysaccharide of Mycoplasma ovipneumoniae Induces Sheep Airway Epithelial Cell Apoptosis via ROS-Dependent JNK/P38 MAPK Pathways. Oxid Med Cell Longev. 2017;2017:6175841 pubmed publisher
Huang W, Ren C, Huang G, Liu J, Liu W, Wang L, et al. Inhibition of store-operated Ca2+ entry counteracts the apoptosis of nasopharyngeal carcinoma cells induced by sodium butyrate. Oncol Lett. 2017;13:921-929 pubmed publisher
Huang Z, Yang G, Shen T, Wang X, Li H, Ren D. Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells. Biomed Pharmacother. 2017;89:623-631 pubmed publisher
Wang H, Xu Y, Wang M, Cheng C, Bian R, Yuan H, et al. Protective effect of naringin against the LPS-induced apoptosis of PC12 cells: Implications for the treatment of neurodegenerative disorders. Int J Mol Med. 2017;39:819-830 pubmed publisher
Zhang G, Xu M, Zhang H, Song Y, Wang J, Zhang C. Up-regulation of granzyme B and perforin by staphylococcal enterotoxin C2 mutant induces enhanced cytotoxicity in Hepa1-6 cells. Toxicol Appl Pharmacol. 2016;313:1-9 pubmed publisher
Tabata T, Petitt M, Fang Hoover J, Zydek M, Pereira L. Persistent Cytomegalovirus Infection in Amniotic Membranes of the Human Placenta. Am J Pathol. 2016;186:2970-2986 pubmed publisher
Mu Y, Yan W, Yin T, Yang J. Curcumin ameliorates high?fat diet?induced spermatogenesis dysfunction. Mol Med Rep. 2016;14:3588-94 pubmed publisher
Zhao L, Zheng X. MicroRNA-490 inhibits tumorigenesis and progression in breast cancer. Onco Targets Ther. 2016;9:4505-16 pubmed publisher
Ye M, Wu Q, Zhang M, Huang J. Lycopene inhibits the cell proliferation and invasion of human head and neck squamous cell carcinoma. Mol Med Rep. 2016;14:2953-8 pubmed publisher
Wei W, Shen C, Song H, Qiu Z, Luo Q. Propranolol sensitizes thyroid cancer cells to cytotoxic effect of vemurafenib. Oncol Rep. 2016;36:1576-84 pubmed publisher
Zhao X, Tao X, Xu L, Yin L, Qi Y, Xu Y, et al. Dioscin Induces Apoptosis in Human Cervical Carcinoma HeLa and SiHa Cells through ROS-Mediated DNA Damage and the Mitochondrial Signaling Pathway. Molecules. 2016;21: pubmed publisher
Lin B, Huang D, Yu C, Mou Y, Liu Y, Zhang D, et al. MicroRNA-184 Modulates Doxorubicin Resistance in Osteosarcoma Cells by Targeting BCL2L1. Med Sci Monit. 2016;22:1761-5 pubmed
Wang Z, Tang F, Hu P, Wang Y, Gong J, Sun S, et al. HDAC6 promotes cell proliferation and confers resistance to gefitinib in lung adenocarcinoma. Oncol Rep. 2016;36:589-97 pubmed publisher
Gao L, Shan W, Zeng W, Hu Y, Wang G, Tian X, et al. Carnosic acid alleviates chronic alcoholic liver injury by regulating the SIRT1/ChREBP and SIRT1/p66shc pathways in rats. Mol Nutr Food Res. 2016;60:1902-11 pubmed publisher
Zhe N, Chen S, Zhou Z, Liu P, Lin X, Yu M, et al. HIF-1α inhibition by 2-methoxyestradiol induces cell death via activation of the mitochondrial apoptotic pathway in acute myeloid leukemia. Cancer Biol Ther. 2016;17:625-34 pubmed publisher
Chen S, Sun K, Feng M, Sang X, Liu B, Zhao Y. Role of glycogen synthase kinase-3? inhibitor AZD1080 in ovarian cancer. Drug Des Devel Ther. 2016;10:1225-32 pubmed publisher
Zhao L, Wen Q, Yang G, Huang Z, Shen T, Li H, et al. Apoptosis induction of dehydrobruceine B on two kinds of human lung cancer cell lines through mitochondrial-dependent pathway. Phytomedicine. 2016;23:114-22 pubmed publisher
Li X, Lin Z, Zhang B, Guo L, Liu S, Li H, et al. β-elemene sensitizes hepatocellular carcinoma cells to oxaliplatin by preventing oxaliplatin-induced degradation of copper transporter 1. Sci Rep. 2016;6:21010 pubmed publisher
Li M, Li J, Gu Q, An J, Cao L, Yang H, et al. EGCG induces lung cancer A549 cell apoptosis by regulating Ku70 acetylation. Oncol Rep. 2016;35:2339-47 pubmed publisher
Jiang S, Wang Y, Yang J, Li J, Feng M, Wang Y, et al. Overexpressed EDIL3 predicts poor prognosis and promotes anchorage-independent tumor growth in human pancreatic cancer. Oncotarget. 2016;7:4226-40 pubmed publisher
Li X, Song Y, Zhang P, Zhu H, Chen L, Xiao Y, et al. Oleanolic acid inhibits cell survival and proliferation of prostate cancer cells in vitro and in vivo through the PI3K/Akt pathway. Tumour Biol. 2016;37:7599-613 pubmed publisher
Liu J, Huang W, Ren C, Wen Q, Liu W, Yang X, et al. Flotillin-2 promotes metastasis of nasopharyngeal carcinoma by activating NF-κB and PI3K/Akt3 signaling pathways. Sci Rep. 2015;5:11614 pubmed publisher
Hu Y, Zhang N, Fan Q, Lin M, Zhang C, Fan G, et al. Protective efficacy of carnosic acid against hydrogen peroxide induced oxidative injury in HepG2 cells through the SIRT1 pathway. Can J Physiol Pharmacol. 2015;93:625-31 pubmed publisher
Dai W, Wang F, Lu J, Xia Y, He L, Chen K, et al. By reducing hexokinase 2, resveratrol induces apoptosis in HCC cells addicted to aerobic glycolysis and inhibits tumor growth in mice. Oncotarget. 2015;6:13703-17 pubmed
Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, et al. Potent effects of dioscin against liver fibrosis. Sci Rep. 2015;5:9713 pubmed publisher
Huang W, Liu J, Feng X, Chen H, Zeng L, Huang G, et al. DLC-1 induces mitochondrial apoptosis and epithelial mesenchymal transition arrest in nasopharyngeal carcinoma by targeting EGFR/Akt/NF-κB pathway. Med Oncol. 2015;32:115 pubmed publisher
Wu P, Zhu X, Jin W, Hao S, Liu Q, Zhang L. Oxaliplatin triggers necrosis as well as apoptosis in gastric cancer SGC-7901 cells. Biochem Biophys Res Commun. 2015;460:183-90 pubmed publisher
Xiang M, Su H, Hong Z, Yang T, Shu G. Chemical composition of total flavonoids from Polygonum amplexicaule and their pro-apoptotic effect on hepatocellular carcinoma cells: Potential roles of suppressing STAT3 signaling. Food Chem Toxicol. 2015;80:62-71 pubmed publisher
Shi J, Ren C, Liu H, Wang L, Zhu B, Huang W, et al. An ESRG-interacting protein, COXII, is involved in pro-apoptosis of human embryonic stem cells. Biochem Biophys Res Commun. 2015;460:130-5 pubmed publisher
product information
CatalogNo :
10783-1-AP
AntigenName :
Bcl-XL
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
BCL2-like 1
Immunogen :
Recombinant Protein
Species :
human, mouse, rat, sheep
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, FC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
Apoptosis regulator Bcl X, BCL2L1, Bcl-XL
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC019307
Category :
Apoptosis;Binding Proteins;Cytoskeleton/Scaffold Proteins;Development;Disease Related;Membrane Proteins;Oncogene(s) and Tumor Suppressor(s);
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
FC 1:0 ; IF 1:25 ; IHC 1:200 ; IP 1:500 ; WB 1:2000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.