| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunohistochemistry knockout validation; mouse; 1:1000; loading ...; fig 8d
| Araki K, Araki A, Honda D, Izumoto T, Hashizume A, Hijikata Y, et al. TDP-43 regulates early-phase insulin secretion via CaV1.2-mediated exocytosis in islets. J Clin Invest. 2019;130:3578-3593 pubmed publisher |
- immunohistochemistry knockout validation; mouse; 1:500; loading ...; fig 1b
| Laclair K, Donde A, Ling J, Jeong Y, Chhabra R, Martin L, et al. Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model. Acta Neuropathol. 2016;132:859-873 pubmed |
- immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 3e
| Lloyd G, Trejo Lopez J, Xia Y, McFarland K, Lincoln S, Ertekin Taner N, et al. Prominent amyloid plaque pathology and cerebral amyloid angiopathy in APP V717I (London) carrier - phenotypic variability in autosomal dominant Alzheimer's disease. Acta Neuropathol Commun. 2020;8:31 pubmed publisher |
- RNA immunoprecipitation; rat; loading ...; fig 5h
| Keihani S, Kluever V, Mandad S, Bansal V, Rahman R, Fritsch E, et al. The long noncoding RNA neuroLNC regulates presynaptic activity by interacting with the neurodegeneration-associated protein TDP-43. Sci Adv. 2019;5:eaay2670 pubmed publisher |
- proximity ligation assay; human; loading ...; fig 2b
- immunocytochemistry; human; loading ...; fig 2d
| Wheeler J, McMillan P, Strovas T, Liachko N, Amlie Wolf A, Kow R, et al. Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain. Sci Transl Med. 2019;11: pubmed publisher |
- immunohistochemistry - free floating section; mouse; 1:200; loading ...; fig 5
- western blot; mouse; 1:1000; loading ...; fig 7a
| Duan W, Guo M, Yi L, Zhang J, Bi Y, Liu Y, et al. Deletion of Tbk1 disrupts autophagy and reproduces behavioral and locomotor symptoms of FTD-ALS in mice. Aging (Albany NY). 2019;11:2457-2476 pubmed publisher |
- western blot; fruit fly ; 1:1000; loading ...; fig 2b
| Berson A, Goodman L, Sartoris A, Otte C, Aykit J, Lee V, et al. Drosophila Ref1/ALYREF regulates transcription and toxicity associated with ALS/FTD disease etiologies. Acta Neuropathol Commun. 2019;7:65 pubmed publisher |
- immunohistochemistry - paraffin section; human; 1:5000; loading ...; fig s8
- immunocytochemistry; human; 1:1000; loading ...; fig 1e
- western blot; human; 1:1000; loading ...; fig 1d
| Melamed Z, López Erauskin J, Baughn M, Zhang O, Drenner K, Sun Y, et al. Premature polyadenylation-mediated loss of stathmin-2 is a hallmark of TDP-43-dependent neurodegeneration. Nat Neurosci. 2019;22:180-190 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; loading ...; fig 9c
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- immunocytochemistry; rat; loading ...; fig 8a
- western blot; rat; 1:1000; loading ...; fig 8b
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- immunocytochemistry; rat; loading ...; fig 1a
| Herzog J, Deshpande M, Shapiro L, Rodal A, Paradis S. TDP-43 misexpression causes defects in dendritic growth. Sci Rep. 2017;7:15656 pubmed publisher |
- immunohistochemistry; human; 1:100; loading ...; fig s3b
| Krug L, Chatterjee N, Borges Monroy R, Hearn S, Liao W, Morrill K, et al. Retrotransposon activation contributes to neurodegeneration in a Drosophila TDP-43 model of ALS. PLoS Genet. 2017;13:e1006635 pubmed publisher |
- immunocytochemistry; human; 1:500; loading ...; fig 3a
- western blot; human; 1:5000; loading ...; fig 4a
| Wobst H, Wesolowski S, Chadchankar J, Delsing L, Jacobsen S, Mukherjee J, et al. Cytoplasmic Relocalization of TAR DNA-Binding Protein 43 Is Not Sufficient to Reproduce Cellular Pathologies Associated with ALS In vitro. Front Mol Neurosci. 2017;10:46 pubmed publisher |
- immunocytochemistry; human; fig s9d
| Shadle S, Zhong J, Campbell A, Conerly M, Jagannathan S, Wong C, et al. DUX4-induced dsRNA and MYC mRNA stabilization activate apoptotic pathways in human cell models of facioscapulohumeral dystrophy. PLoS Genet. 2017;13:e1006658 pubmed publisher |
- immunocytochemistry; human; loading ...; fig 5a
| Lee K, Zhang P, Kim H, Mitrea D, Sarkar M, Freibaum B, et al. C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles. Cell. 2016;167:774-788.e17 pubmed publisher |
- immunocytochemistry; human; 1:500; loading ...; fig 5c
| Smethurst P, Newcombe J, Troakes C, Simone R, Chen Y, Patani R, et al. In vitro prion-like behaviour of TDP-43 in ALS. Neurobiol Dis. 2016;96:236-247 pubmed publisher |
- western blot; human; 1:2000; fig 6d
| Kapeli K, Pratt G, Vu A, Hutt K, Martinez F, Sundararaman B, et al. Distinct and shared functions of ALS-associated proteins TDP-43, FUS and TAF15 revealed by multisystem analyses. Nat Commun. 2016;7:12143 pubmed publisher |
- immunoprecipitation; mouse; fig 1
- western blot; mouse; 1:1000; fig 1
| Li R, Dong Q, Yuan X, Zeng X, Gao Y, Chiao C, et al. Misregulation of Alternative Splicing in a Mouse Model of Rett Syndrome. PLoS Genet. 2016;12:e1006129 pubmed publisher |
- immunohistochemistry; mouse; 1:100
| Vernay A, Therreau L, Blot B, Risson V, Dirrig Grosch S, Waegaert R, et al. A transgenic mouse expressing CHMP2Bintron5 mutant in neurons develops histological and behavioural features of amyotrophic lateral sclerosis and frontotemporal dementia. Hum Mol Genet. 2016;25:3341-3360 pubmed publisher |
- immunohistochemistry - paraffin section; human; fig 1
| Ando K, Tomimura K, Sazdovitch V, Suain V, Yilmaz Z, Authelet M, et al. Level of PICALM, a key component of clathrin-mediated endocytosis, is correlated with levels of phosphotau and autophagy-related proteins and is associated with tau inclusions in AD, PSP and Pick disease. Neurobiol Dis. 2016;94:32-43 pubmed publisher |
- western blot; human; 1:500; fig 5
| Onesto E, Colombrita C, Gumina V, Borghi M, Dusi S, Doretti A, et al. Gene-specific mitochondria dysfunctions in human TARDBP and C9ORF72 fibroblasts. Acta Neuropathol Commun. 2016;4:47 pubmed publisher |
- immunocytochemistry; human; fig 8
- western blot; human; fig 3
| Alquezar C, Salado I, de la Encarnación A, Perez D, Moreno F, Gil C, et al. Targeting TDP-43 phosphorylation by Casein Kinase-1? inhibitors: a novel strategy for the treatment of frontotemporal dementia. Mol Neurodegener. 2016;11:36 pubmed publisher |
- immunohistochemistry - paraffin section; mouse; loading ...; fig s3g
| O Rourke J, Bogdanik L, Yáñez A, Lall D, Wolf A, Muhammad A, et al. C9orf72 is required for proper macrophage and microglial function in mice. Science. 2016;351:1324-9 pubmed publisher |
- western blot; mouse; 1:10,000; fig 6
| Sharma A, Lyashchenko A, Lu L, Nasrabady S, Elmaleh M, Mendelsohn M, et al. ALS-associated mutant FUS induces selective motor neuron degeneration through toxic gain of function. Nat Commun. 2016;7:10465 pubmed publisher |
- western blot; brewer's yeast; fig 3
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| Briese M, Saal Bauernschubert L, Lüningschrör P, Moradi M, Dombert B, Surrey V, et al. Loss of Tdp-43 disrupts the axonal transcriptome of motoneurons accompanied by impaired axonal translation and mitochondria function. Acta Neuropathol Commun. 2020;8:116 pubmed publisher |
| Zhu Y, Liu Y, Yang F, Chen W, Jiang J, He P, et al. All-Trans Retinoic Acid Exerts Neuroprotective Effects in Amyotrophic Lateral Sclerosis-Like Tg (SOD1*G93A)1Gur Mice. Mol Neurobiol. 2020;57:3603-3615 pubmed publisher |
| Wu H, Sun H, He Z, Chen X, Li Y, Zhao X, et al. The effect and mechanism of 19S proteasome PSMD11/Rpn6 subunit in D-Galactose induced mimetic aging models. Exp Cell Res. 2020;394:112093 pubmed publisher |
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| Martínez González L, Rodríguez Cueto C, Cabezudo D, Bartolomé F, Andrés Benito P, Ferrer I, et al. Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment. Sci Rep. 2020;10:4449 pubmed publisher |
| Ormeño F, Hormazabal J, Moreno J, Riquelme F, Rios J, Criollo A, et al. Chaperone Mediated Autophagy Degrades TDP-43 Protein and Is Affected by TDP-43 Aggregation. Front Mol Neurosci. 2020;13:19 pubmed publisher |
| Huang S, Wu L, Lee M, Chang C, Cheng W, Fang Y, et al. A robust TDP-43 knock-in mouse model of ALS. Acta Neuropathol Commun. 2020;8:3 pubmed publisher |
| Zhao L, Ke H, Xu H, Wang G, Zhang H, Zou L, et al. TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh. Nat Commun. 2020;11:341 pubmed publisher |
| Braak H, Del Tredici K. From the Entorhinal Region via the Prosubiculum to the Dentate Fascia: Alzheimer Disease-Related Neurofibrillary Changes in the Temporal Allocortex. J Neuropathol Exp Neurol. 2020;79:163-175 pubmed publisher |
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| Nguyen T, Kabotyanski E, Reineke L, Shao J, Xiong F, Lee J, et al. The SINEB1 element in the long non-coding RNA Malat1 is necessary for TDP-43 proteostasis. Nucleic Acids Res. 2020;48:2621-2642 pubmed publisher |
| Zhou Q, Mareljic N, Michaelsen M, Parhizkar S, Heindl S, Nuscher B, et al. Active poly-GA vaccination prevents microglia activation and motor deficits in a C9orf72 mouse model. EMBO Mol Med. 2020;12:e10919 pubmed publisher |
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| Hans F, Glasebach H, Kahle P. Multiple distinct pathways lead to hyperubiquitylated insoluble TDP-43 protein independent of its translocation into stress granules. J Biol Chem. 2020;295:673-689 pubmed publisher |
| Zhao C, Devlin A, Chouhan A, Selvaraj B, Stavrou M, Burr K, et al. Mutant C9orf72 human iPSC-derived astrocytes cause non-cell autonomous motor neuron pathophysiology. Glia. 2019;: pubmed publisher |
| Thierry M, Boluda S, Delatour B, Marty S, Seilhean D, Potier M, et al. Human subiculo-fornico-mamillary system in Alzheimer's disease: Tau seeding by the pillar of the fornix. Acta Neuropathol. 2019;: pubmed publisher |
| Klingstedt T, Ghetti B, Holton J, Ling H, Nilsson K, Goedert M. Luminescent conjugated oligothiophenes distinguish between α-synuclein assemblies of Parkinson's disease and multiple system atrophy. Acta Neuropathol Commun. 2019;7:193 pubmed publisher |
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| Quadri Z, Johnson N, Zamudio F, Miller A, Peters M, Smeltzer S, et al. Overexpression of human wtTDP-43 causes impairment in hippocampal plasticity and behavioral deficits in CAMKII-tTa transgenic mouse model. Mol Cell Neurosci. 2019;102:103418 pubmed publisher |
| Chadchankar J, Korboukh V, Conway L, Wobst H, Walker C, Doig P, et al. Inactive USP14 and inactive UCHL5 cause accumulation of distinct ubiquitinated proteins in mammalian cells. PLoS ONE. 2019;14:e0225145 pubmed publisher |
| Couly S, Khalil B, Viguier V, Roussel J, Maurice T, Liévens J. Sigma-1 receptor is a key genetic modulator in amyotrophic lateral sclerosis. Hum Mol Genet. 2019;: pubmed publisher |
| Kawaguchi T, Rollins M, Moinpour M, MORERA A, Ebmeier C, Old W, et al. Changes to the TDP-43 and FUS Interactomes Induced by DNA Damage. J Proteome Res. 2019;: pubmed publisher |
| Lee S, Jeon Y, Cha S, Kim S, Kwon Y, Jo M, et al. PTK2/FAK regulates UPS impairment via SQSTM1/p62 phosphorylation in TARDBP/TDP-43 proteinopathies. Autophagy. 2019;:1-17 pubmed publisher |
| Garces M, Guijarro M, Vargas A, Badiola J, Monzon M. Neuroglial patterns are shared by cerebella from prion and prion-like disorder affected patients. Mech Ageing Dev. 2019;184:111176 pubmed publisher |
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| Bizarro J, Bhardwaj A, Smith S, Meier U. Nopp140-mediated concentration of telomerase in Cajal bodies regulates telomere length. Mol Biol Cell. 2019;30:3136-3150 pubmed publisher |
| MORERA A, Ahmed N, Schwartz J. TDP-43 regulates transcription at protein-coding genes and Alu retrotransposons. Biochim Biophys Acta Gene Regul Mech. 2019;1862:194434 pubmed publisher |
| Schmidt H, Barreau A, Rohatgi R. Phase separation-deficient TDP43 remains functional in splicing. Nat Commun. 2019;10:4890 pubmed publisher |
| Williamson M, Finelli M, Sleigh J, Reddington A, Gordon D, Talbot K, et al. Neuronal over-expression of Oxr1 is protective against ALS-associated mutant TDP-43 mislocalisation in motor neurons and neuromuscular defects in vivo. Hum Mol Genet. 2019;28:3584-3599 pubmed publisher |
| Zhu J, Wang N, Li X, Zheng X, Zhao J, Xia H, et al. Suppression of Progranulin Expression Leads to Formation of Intranuclear TDP-43 Inclusions In Vitro: A Cell Model of Frontotemporal Lobar Degeneration. J Neuropathol Exp Neurol. 2019;78:1124-1129 pubmed publisher |
| Brettle M, Stefen H, Djordjevic A, Fok S, Chan J, Van Hummel A, et al. Developmental Expression of Mutant PFN1 in Motor Neurons Impacts Neuronal Growth and Motor Performance of Young and Adult Mice. Front Mol Neurosci. 2019;12:231 pubmed publisher |
| Chen H, Topp S, Hui H, Zacco E, Katarya M, McLoughlin C, et al. RRM adjacent TARDBP mutations disrupt RNA binding and enhance TDP-43 proteinopathy. Brain. 2019;142:3753-3770 pubmed publisher |
| Mori S, Honda H, Ishii T, Yoshimura M, Sasagasako N, Suzuki S, et al. Expanded polyglutamine impairs normal nuclear distribution of fused in sarcoma and poly (rC)-binding protein 1 in Huntington's disease. Neuropathology. 2019;39:358-367 pubmed publisher |
| Chen J, Nathaniel D, Raghavan P, Nelson M, Tian R, Tse E, et al. Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. J Biol Chem. 2019;294:18952-18966 pubmed publisher |
| Liao Y, Fernandopulle M, Wang G, Choi H, Hao L, Drerup C, et al. RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether. Cell. 2019;179:147-164.e20 pubmed publisher |
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| Tariq A, Lin J, Jackrel M, Hesketh C, Carman P, Mack K, et al. Mining Disaggregase Sequence Space to Safely Counter TDP-43, FUS, and α-Synuclein Proteotoxicity. Cell Rep. 2019;28:2080-2095.e6 pubmed publisher |
| Heyburn L, Abutarboush R, Goodrich S, Urioste R, Batuure A, Statz J, et al. Repeated Low-Level Blast Overpressure Leads to Endovascular Disruption and Alterations in TDP-43 and Piezo2 in a Rat Model of Blast TBI. Front Neurol. 2019;10:766 pubmed publisher |
| Yamashita S, Matsuo Y, Tawara N, Hara K, Yamamoto M, Nishikami T, et al. CYLD dysregulation in pathogenesis of sporadic inclusion body myositis. Sci Rep. 2019;9:11606 pubmed publisher |
| Fischer N, Preuße C, Radke J, Pehl D, Allenbach Y, Schneider U, et al. Sequestosome-1 (p62) expression reveals chaperone-assisted selective autophagy in immune-mediated necrotizing myopathies. Brain Pathol. 2019;: pubmed publisher |
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| Sugai A, Kato T, Koyama A, Koike Y, Konno T, Ishihara T, et al. Non-genetically modified models exhibit TARDBP mRNA increase due to perturbed TDP-43 autoregulation. Neurobiol Dis. 2019;130:104534 pubmed publisher |
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| Hicks D, Cross L, Williamson R, Rattray M. Endoplasmic Reticulum Stress Signalling Induces Casein Kinase 1-Dependent Formation of Cytosolic TDP-43 Inclusions in Motor Neuron-Like Cells. Neurochem Res. 2019;: pubmed publisher |
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| Kattuah W, Rogelj B, King A, Shaw C, Hortobagyi T, Troakes C. Heterogeneous Nuclear Ribonucleoprotein E2 (hnRNP E2) Is a Component of TDP-43 Aggregates Specifically in the A and C Pathological Subtypes of Frontotemporal Lobar Degeneration. Front Neurosci. 2019;13:551 pubmed publisher |
| Koza P, Beroun A, Konopka A, Gorkiewicz T, Bijoch L, Torres J, et al. Neuronal TDP-43 depletion affects activity-dependent plasticity. Neurobiol Dis. 2019;130:104499 pubmed publisher |
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| Wang P, Deng J, Dong J, Liu J, Bigio E, Mesulam M, et al. TDP-43 induces mitochondrial damage and activates the mitochondrial unfolded protein response. PLoS Genet. 2019;15:e1007947 pubmed publisher |
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| Liu E, Russ J, Cali C, Phan J, Amlie Wolf A, Lee E. Loss of Nuclear TDP-43 Is Associated with Decondensation of LINE Retrotransposons. Cell Rep. 2019;27:1409-1421.e6 pubmed publisher |
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| Wang B, Maxwell B, Joo J, Gwon Y, Messing J, Mishra A, et al. ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97. Mol Cell. 2019;74:742-757.e8 pubmed publisher |
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| Horos R, Büscher M, Kleinendorst R, Alleaume A, Tarafder A, Schwarzl T, et al. The Small Non-coding Vault RNA1-1 Acts as a Riboregulator of Autophagy. Cell. 2019;176:1054-1067.e12 pubmed publisher |
| Ling S, Dastidar S, Tokunaga S, Ho W, Lim K, Ilieva H, et al. Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis. elife. 2019;8: pubmed publisher |
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| Tsai R, Bejanin A, Lesman Segev O, LaJoie R, Visani A, Bourakova V, et al. 18F-flortaucipir (AV-1451) tau PET in frontotemporal dementia syndromes. Alzheimers Res Ther. 2019;11:13 pubmed publisher |
| Elia L, Mason A, Alijagic A, Finkbeiner S. Genetic Regulation of Neuronal Progranulin Reveals a Critical Role for the Autophagy-Lysosome Pathway. J Neurosci. 2019;39:3332-3344 pubmed publisher |
| Pozzi S, Thammisetty S, Codron P, Rahimian R, Plourde K, Soucy G, et al. Virus-mediated delivery of antibody targeting TAR DNA-binding protein-43 mitigates associated neuropathology. J Clin Invest. 2019;129:1581-1595 pubmed publisher |
| Arhzaouy K, Papadopoulos C, Schulze N, Pittman S, Meyer H, Weihl C. VCP maintains lysosomal homeostasis and TFEB activity in differentiated skeletal muscle. Autophagy. 2019;:1-18 pubmed publisher |
| Klim J, Williams L, Limone F, Guerra San Juan I, Davis Dusenbery B, Mordes D, et al. ALS-implicated protein TDP-43 sustains levels of STMN2, a mediator of motor neuron growth and repair. Nat Neurosci. 2019;22:167-179 pubmed publisher |
| Chen Y, Cohen T. Aggregation of the nucleic acid-binding protein TDP-43 occurs via distinct routes that are coordinated with stress granule formation. J Biol Chem. 2019;294:3696-3706 pubmed publisher |
| Ebstein S, Yagudayeva I, Shneider N. Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS. Cell Rep. 2019;26:364-373.e4 pubmed publisher |
| Aizawa H, Yamashita T, Kato H, Kimura T, Kwak S. Impaired Nucleoporins Are Present in Sporadic Amyotrophic Lateral Sclerosis Motor Neurons that Exhibit Mislocalization of the 43-kDa TAR DNA-Binding Protein. J Clin Neurol. 2019;15:62-67 pubmed publisher |
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