| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; human; fig 1
- western blot knockout validation; mouse; fig 2
| Grainger D, Kutzler L, Rannels S, Kimball S. Validation of a commercially available anti-REDD1 antibody using RNA interference and REDD1-/- mouse embryonic fibroblasts. F1000Res. 2016;5:250 pubmed publisher |
- western blot; human; loading ...; fig 4a
| Liu X, Cai S, Zhang C, Liu Z, Luo J, Xing B, et al. Deacetylation of NAT10 by Sirt1 promotes the transition from rRNA biogenesis to autophagy upon energy stress. Nucleic Acids Res. 2018;46:9601-9616 pubmed publisher |
- western blot; mouse; 1:1000; loading ...; fig 5h
| Lee C, Hanna A, Wang H, Dagnino Acosta A, Joshi A, Knoblauch M, et al. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017;8:14659 pubmed publisher |
- western blot; human; 1:500; loading ...; fig 1a
| Salsman J, Stathakis A, Parker E, Chung D, Anthes L, Koskowich K, et al. PML nuclear bodies contribute to the basal expression of the mTOR inhibitor DDIT4. Sci Rep. 2017;7:45038 pubmed publisher |
| Bouquier N, Moutin E, Tintignac L, Reverbel A, Jublanc E, Sinnreich M, et al. AIMTOR, a BRET biosensor for live imaging, reveals subcellular mTOR signaling and dysfunctions. BMC Biol. 2020;18:81 pubmed publisher |
| Kanno A, Asahara S, Furubayashi A, Masuda K, Yoshitomi R, Suzuki E, et al. GCN2 regulates pancreatic β cell mass by sensing intracellular amino acid levels. JCI Insight. 2020;5: pubmed publisher |
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| Dumas K, Ayachi C, Gilleron J, Lacas Gervais S, Pastor F, Favier F, et al. REDD1 deficiency protects against nonalcoholic hepatic steatosis induced by high-fat diet. FASEB J. 2020;34:5046-5060 pubmed publisher |
| Feng Y, Song K, Shang W, Chen L, Wang C, Pang B, et al. REDD1 overexpression in oral squamous cell carcinoma may predict poor prognosis and correlates with high microvessel density. Oncol Lett. 2020;19:431-441 pubmed publisher |
| Stevens A, Xiang M, Heppler L, Tošić I, Jiang K, Munoz J, et al. Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation. Blood Adv. 2019;3:4215-4227 pubmed publisher |
| Merle A, Jollet M, Britto F, Goustard B, Bendridi N, Rieusset J, et al. Endurance exercise decreases protein synthesis and ER-mitochondria contacts in mice skeletal muscle. J Appl Physiol (1985). 2019;: pubmed publisher |
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| McCrary M, Jiang M, Giddens M, Zhang J, Owino S, Wei Z, et al. Protective effects of GPR37 via regulation of inflammation and multiple cell death pathways after ischemic stroke in mice. FASEB J. 2019;:fj201900070R pubmed publisher |
| Wang B, Peng L, Ouyang H, Wang L, He D, Zhong J, et al. Induction of DDIT4 Impairs Autophagy Through Oxidative Stress in Dry Eye. Invest Ophthalmol Vis Sci. 2019;60:2836-2847 pubmed publisher |
| Miller W, Toro A, Barber A, Dennis M. REDD1 Activates a ROS-Generating Feedback Loop in the Retina of Diabetic Mice. Invest Ophthalmol Vis Sci. 2019;60:2369-2379 pubmed publisher |
| Soni C, Sinha I, Fasnacht M, Olsen N, Rahman Z, Sinha R. Selenium supplementation suppresses immunological and serological features of lupus in B6.Sle1b mice. Autoimmunity. 2019;52:57-68 pubmed publisher |
| Gordon B, Rossetti M, Eroshkin A. Arrdc2 and Arrdc3 elicit divergent changes in gene expression in skeletal muscle following anabolic and catabolic stimuli. Physiol Genomics. 2019;51:208-217 pubmed publisher |
| Su J, Wang M, Yan Y, Ju S, Chen J, Wu X. Increased REDD1 facilitates neuronal damage after subarachnoid hemorrhage. Neurochem Int. 2019;128:14-20 pubmed publisher |
| Liu Z, Li T, Zhu F, Deng S, Li X, He Y. Regulatory roles of miR-22/Redd1-mediated mitochondrial ROS and cellular autophagy in ionizing radiation-induced BMSC injury. Cell Death Dis. 2019;10:227 pubmed publisher |
| Dungan C, Gordon B, Williamson D. Acute treadmill exercise discriminately improves the skeletal muscle insulin-stimulated growth signaling responses in mice lacking REDD1. Physiol Rep. 2019;7:e14011 pubmed publisher |
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| Nogami A, Okada K, Ishida S, Akiyama H, Umezawa Y, Miura O. Inhibition of the STAT5/Pim Kinase Axis Enhances Cytotoxic Effects of Proteasome Inhibitors on FLT3-ITD-Positive AML Cells by Cooperatively Inhibiting the mTORC1/4EBP1/S6K/Mcl-1 Pathway. Transl Oncol. 2019;12:336-349 pubmed publisher |
| Seong M, Lee J, Kang H. Hypoxia-induced regulation of mTOR signaling by miR-7 targeting REDD1. J Cell Biochem. 2019;120:4523-4532 pubmed publisher |
| Chang B, Meng J, Zhu H, Du X, Sun L, Wang L, et al. Overexpression of the recently identified oncogene REDD1 correlates with tumor progression and is an independent unfavorable prognostic factor for ovarian carcinoma. Diagn Pathol. 2018;13:87 pubmed publisher |
| Baida G, Bhalla P, Yemelyanov A, Stechschulte L, Shou W, Readhead B, et al. Deletion of the glucocorticoid receptor chaperone FKBP51 prevents glucocorticoid-induced skin atrophy. Oncotarget. 2018;9:34772-34783 pubmed publisher |
| Shimkus K, Jefferson L, Gordon B, Kimball S. Repressors of mTORC1 act to blunt the anabolic response to feeding in the soleus muscle of a cast-immobilized mouse hindlimb. Physiol Rep. 2018;6:e13891 pubmed publisher |
| Castro W, Chelbi S, Niogret C, Ramón Barros C, Welten S, Osterheld K, et al. The transcription factor Rfx7 limits metabolism of NK cells and promotes their maintenance and immunity. Nat Immunol. 2018;19:809-820 pubmed publisher |
| Tiwarekar V, Wohlfahrt J, Fehrholz M, Scholz C, Kneitz S, Schneider Schaulies J. APOBEC3G-Regulated Host Factors Interfere with Measles Virus Replication: Role of REDD1 and Mammalian TORC1 Inhibition. J Virol. 2018;92: pubmed publisher |
| Cho S, Kim K, Yang J, Kim J, Park S, Kim S, et al. Induction of REDD1 via AP-1 prevents oxidative stress-mediated injury in hepatocytes. Free Radic Biol Med. 2018;124:221-231 pubmed publisher |
| Walton Z, Patel C, Brooks R, Yu Y, Ibrahim Hashim A, Riddle M, et al. Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. Cell. 2018;174:72-87.e32 pubmed publisher |
| Suryawan A, Davis T. Amino Acid- and Insulin-Induced Activation of mTORC1 in Neonatal Piglet Skeletal Muscle Involves Sestin2-GATOR2, Rag A/C-mTOR, and RHEB-mTOR Complex Formation. J Nutr. 2018;148:825-833 pubmed publisher |
| Ceelen J, Schols A, Thielen N, Haegens A, Gray D, Kelders M, et al. Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation. Respir Res. 2018;19:80 pubmed publisher |
| Gnimassou O, Fernández Verdejo R, Brook M, Naslain D, Balan E, Sayda M, et al. Environmental hypoxia favors myoblast differentiation and fast phenotype but blunts activation of protein synthesis after resistance exercise in human skeletal muscle. FASEB J. 2018;32:5272-5284 pubmed publisher |
| Lesovaya E, Agarwal S, Readhead B, Vinokour E, Baida G, Bhalla P, et al. Rapamycin Modulates Glucocorticoid Receptor Function, Blocks Atrophogene REDD1, and Protects Skin from Steroid Atrophy. J Invest Dermatol. 2018;138:1935-1944 pubmed publisher |
| Yang J, Zhang Y, Tong J, Lv H, Zhang C, Chen Z. Dysfunction of DNA damage-inducible transcript 4 in the decidua is relevant to the pathogenesis of preeclampsia. Biol Reprod. 2018;98:821-833 pubmed publisher |
| Xu Q, Lin G, Xu H, Hu L, Wang Y, Du S, et al. MLN4924 neddylation inhibitor promotes cell death in paclitaxel-resistant human lung adenocarcinoma cells. Oncol Lett. 2018;15:515-521 pubmed publisher |
| DeWaal D, Nogueira V, Terry A, Patra K, Jeon S, Guzman G, et al. Hexokinase-2 depletion inhibits glycolysis and induces oxidative phosphorylation in hepatocellular carcinoma and sensitizes to metformin. Nat Commun. 2018;9:446 pubmed publisher |
| Miller W, Yang C, Mihailescu M, Moore J, Dai W, Barber A, et al. Deletion of the Akt/mTORC1 Repressor REDD1 Prevents Visual Dysfunction in a Rodent Model of Type 1 Diabetes. Diabetes. 2018;67:110-119 pubmed publisher |
| Jeon M, Min K, Woo S, Seo S, Kim S, Park J, et al. Volasertib Enhances Sensitivity to TRAIL in Renal Carcinoma Caki Cells through Downregulation of c-FLIP Expression. Int J Mol Sci. 2017;18: pubmed publisher |
| Gordon B, Steiner J, Rossetti M, Qiao S, Ellisen L, Govindarajan S, et al. REDD1 induction regulates the skeletal muscle gene expression signature following acute aerobic exercise. Am J Physiol Endocrinol Metab. 2017;313:E737-E747 pubmed publisher |
| Roberts M, Wallace M, Tomilov A, Zhou Z, Marcotte G, Tran D, et al. A Ketogenic Diet Extends Longevity and Healthspan in Adult Mice. Cell Metab. 2017;26:539-546.e5 pubmed publisher |
| Larsen L, Sandø Pedersen S, Ørstrup L, Grunnet N, Quistorff B, Mortensen O. Gestational Protein Restriction in Wistar Rats; Effect of Taurine Supplementation on Properties of Newborn Skeletal Muscle. Adv Exp Med Biol. 2017;975 Pt 1:413-433 pubmed publisher |
| Pastor F, Dumas K, Barthélémy M, Regazzetti C, Druelle N, Peraldi P, et al. Implication of REDD1 in the activation of inflammatory pathways. Sci Rep. 2017;7:7023 pubmed publisher |
| Ogasawara R, Arihara Y, Takegaki J, Nakazato K, Ishii N. Relationship between exercise volume and muscle protein synthesis in a rat model of resistance exercise. J Appl Physiol (1985). 2017;123:710-716 pubmed publisher |
| Reidy P, McKenzie A, Brunker P, Nelson D, Barrows K, Supiano M, et al. Neuromuscular Electrical Stimulation Combined with Protein Ingestion Preserves Thigh Muscle Mass But Not Muscle Function in Healthy Older Adults During 5 Days of Bed Rest. Rejuvenation Res. 2017;20:449-461 pubmed publisher |
| Shimazu K, Tada Y, Morinaga T, Shingyoji M, Sekine I, Shimada H, et al. Metformin produces growth inhibitory effects in combination with nutlin-3a on malignant mesothelioma through a cross-talk between mTOR and p53 pathways. BMC Cancer. 2017;17:309 pubmed publisher |
| Black A, Gordon B, Dennis M, Jefferson L, Kimball S. Regulation of protein and mRNA expression of the mTORC1 repressor REDD1 in response to leucine and serum. Biochem Biophys Rep. 2016;8:296-301 pubmed publisher |
| Alvarez Garcia O, Matsuzaki T, Olmer M, Plate L, Kelly J, Lotz M. Regulated in Development and DNA Damage Response 1 Deficiency Impairs Autophagy and Mitochondrial Biogenesis in Articular Cartilage and Increases the Severity of Experimental Osteoarthritis. Arthritis Rheumatol. 2017;69:1418-1428 pubmed publisher |
| Vila I, Yao Y, Kim G, Xia W, Kim H, Kim S, et al. A UBE2O-AMPK?2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy. Cancer Cell. 2017;31:208-224 pubmed publisher |
| Wagner R, Stübiger G, Veigel D, Wuczkowski M, Lanzerstorfer P, Weghuber J, et al. Multi-level suppression of receptor-PI3K-mTORC1 by fatty acid synthase inhibitors is crucial for their efficacy against ovarian cancer cells. Oncotarget. 2017;8:11600-11613 pubmed publisher |
| Dungan C, Williamson D. Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTOR axis. Biochem Biophys Res Commun. 2017;482:1067-1072 pubmed publisher |
| Gharibi B, Ghuman M, Hughes F. DDIT4 regulates mesenchymal stem cell fate by mediating between HIF1α and mTOR signalling. Sci Rep. 2016;6:36889 pubmed publisher |
| D Hulst G, Ferri A, Naslain D, Bertrand L, Horman S, Francaux M, et al. Fifteen days of 3,200 m simulated hypoxia marginally regulates markers for protein synthesis and degradation in human skeletal muscle. Hypoxia (Auckl). 2016;4:1-14 pubmed |
| Crowell K, Soybel D, Lang C. Restorative Mechanisms Regulating Protein Balance in Skeletal Muscle During Recovery From Sepsis. Shock. 2017;47:463-473 pubmed publisher |
| Hernández Saavedra D, Sanders L, Perez M, Kosmider B, Smith L, Mitchell J, et al. RTP801 Amplifies Nicotinamide Adenine Dinucleotide Phosphate Oxidase-4-Dependent Oxidative Stress Induced by Cigarette Smoke. Am J Respir Cell Mol Biol. 2017;56:62-73 pubmed publisher |
| Zhou F, Chen H, Wang X, Yu P, Hu Y. Hypoxia-induced regulation of placental REDD1 and mTOR was impaired in a rat model of estrogen-induced cholestasis. Arch Gynecol Obstet. 2016;294:1219-1226 pubmed |
| Canal M, Martín Flores N, Pérez Sisqués L, Romaní Aumedes J, Altas B, Man H, et al. Loss of NEDD4 contributes to RTP801 elevation and neuron toxicity: implications for Parkinson's disease. Oncotarget. 2016;7:58813-58831 pubmed publisher |
| Gordon B, Liu C, Steiner J, Nader G, Jefferson L, Kimball S. Loss of REDD1 augments the rate of the overload-induced increase in muscle mass. Am J Physiol Regul Integr Comp Physiol. 2016;311:R545-57 pubmed publisher |
| Crowell K, Steiner J, Coleman C, Lang C. Decreased Whole-Body Fat Mass Produced by Chronic Alcohol Consumption is Associated with Activation of S6K1-Mediated Protein Synthesis and Increased Autophagy in Epididymal White Adipose Tissue. Alcohol Clin Exp Res. 2016;40:1832-45 pubmed publisher |
| Dungan C, Li J, Williamson D. Caloric Restriction Normalizes Obesity-Induced Alterations on Regulators of Skeletal Muscle Growth Signaling. Lipids. 2016;51:905-12 pubmed publisher |
| Park K, Teoh J, Wang Y, Brosková Z, Bayoumi A, Tang Y, et al. Carvedilol-responsive microRNAs, miR-199a-3p and -214 protect cardiomyocytes from simulated ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2016;311:H371-83 pubmed publisher |
| Park J, Lee C. Time-Course Change of Redd1 Expressions in the Hippocampal CA1 Region Following Chronic Cerebral Hypoperfusion. Cell Mol Neurobiol. 2017;37:563-569 pubmed publisher |
| Woo S, Lee W, Min K, Kim D, Park S, Nam S, et al. Rottlerin induces cyclooxygenase-2 upregulation through an ATF4 and reactive oxygen species-independent pathway in HEI-OC1 cells. Mol Med Rep. 2016;14:845-50 pubmed publisher |
| Alvarez Garcia O, Olmer M, Akagi R, Akasaki Y, Fisch K, Shen T, et al. Suppression of REDD1 in osteoarthritis cartilage, a novel mechanism for dysregulated mTOR signaling and defective autophagy. Osteoarthritis Cartilage. 2016;24:1639-47 pubmed publisher |
| Barakat D, Mendonca J, Barberi T, Zhang J, Kachhap S, Paz Priel I, et al. C/EBPβ regulates sensitivity to bortezomib in prostate cancer cells by inducing REDD1 and autophagosome-lysosome fusion. Cancer Lett. 2016;375:152-161 pubmed publisher |
| Moore J, Miller W, Dennis M. Glucosamine induces REDD1 to suppress insulin action in retinal Müller cells. Cell Signal. 2016;28:384-390 pubmed publisher |
| Choi H, Ahn J, Park J, Won M, Lee C. Age-dependent changes in the protein expression levels of Redd1 and mTOR in the gerbil hippocampus during normal aging. Mol Med Rep. 2016;13:2409-14 pubmed publisher |
| Watson A, Lipina C, McArdle H, Taylor P, Hundal H. Iron depletion suppresses mTORC1-directed signalling in intestinal Caco-2 cells via induction of REDD1. Cell Signal. 2016;28:412-424 pubmed publisher |
| Francaux M, Demeulder B, Naslain D, Fortin R, Lutz O, Caty G, et al. Aging Reduces the Activation of the mTORC1 Pathway after Resistance Exercise and Protein Intake in Human Skeletal Muscle: Potential Role of REDD1 and Impaired Anabolic Sensitivity. Nutrients. 2016;8: pubmed publisher |
| Steiner J, Kimball S, Lang C. Acute Alcohol-Induced Decrease in Muscle Protein Synthesis in Female Mice Is REDD-1 and mTOR-Independent. Alcohol Alcohol. 2016;51:242-50 pubmed publisher |
| Reuschel E, Wang J, Shivers D, Muthumani K, Weiner D, Ma Z, et al. REDD1 Is Essential for Optimal T Cell Proliferation and Survival. PLoS ONE. 2015;10:e0136323 pubmed publisher |
| Lee D, Kim J, Kim W, Jeoung D, Lee H, Ha K, et al. Lipopolysaccharide induction of REDD1 is mediated by two distinct CREB-dependent mechanisms in macrophages. FEBS Lett. 2015;589:2859-65 pubmed publisher |
| Philp A, Schenk S, Perez Schindler J, Hamilton D, Breen L, Laverone E, et al. Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise. J Physiol. 2015;593:4275-84 pubmed publisher |
| MartÃn Flores N, Romanà Aumedes J, Rué L, Canal M, Sanders P, Straccia M, et al. RTP801 Is Involved in Mutant Huntingtin-Induced Cell Death. Mol Neurobiol. 2016;53:2857-2868 pubmed publisher |
| Wu X, Su J, Chen L, Ma B, Gu X, Zhu L. Ginkgolide B Protects Neurons from Ischemic Injury by Inhibiting the Expression of RTP801. Cell Mol Neurobiol. 2015;35:943-52 pubmed publisher |
| Sesen J, Dahan P, Scotland S, Saland E, Dang V, Lemarie A, et al. Metformin inhibits growth of human glioblastoma cells and enhances therapeutic response. PLoS ONE. 2015;10:e0123721 pubmed publisher |
| Benyoucef A, Calvo J, Renou L, Arcangeli M, van den Heuvel A, Amsellem S, et al. The SCL/TAL1 Transcription Factor Represses the Stress Protein DDiT4/REDD1 in Human Hematopoietic Stem/Progenitor Cells. Stem Cells. 2015;33:2268-79 pubmed publisher |
| Papageorgiou A, Rapley J, Mesirov J, Tamayo P, Avruch J. A genome-wide siRNA screen in mammalian cells for regulators of S6 phosphorylation. PLoS ONE. 2015;10:e0116096 pubmed publisher |
| Steiner J, Gordon B, Lang C. Moderate alcohol consumption does not impair overload-induced muscle hypertrophy and protein synthesis. Physiol Rep. 2015;3: pubmed publisher |
| Desantis A, Bruno T, Catena V, De Nicola F, Goeman F, Iezzi S, et al. Che-1-induced inhibition of mTOR pathway enables stress-induced autophagy. EMBO J. 2015;34:1214-30 pubmed publisher |
| Gordon B, Williamson D, Lang C, Jefferson L, Kimball S. Nutrient-induced stimulation of protein synthesis in mouse skeletal muscle is limited by the mTORC1 repressor REDD1. J Nutr. 2015;145:708-13 pubmed publisher |
| Steiner J, Lang C. Alcohol intoxication following muscle contraction in mice decreases muscle protein synthesis but not mTOR signal transduction. Alcohol Clin Exp Res. 2015;39:1-10 pubmed publisher |
| Wang S, Chen X, Hu J, Jiang J, Li Y, Chan Salis K, et al. ATF4 Gene Network Mediates Cellular Response to the Anticancer PAD Inhibitor YW3-56 in Triple-Negative Breast Cancer Cells. Mol Cancer Ther. 2015;14:877-88 pubmed publisher |
| Dennis M, Kimball S, Fort P, Jefferson L. Regulated in development and DNA damage 1 is necessary for hyperglycemia-induced vascular endothelial growth factor expression in the retina of diabetic rodents. J Biol Chem. 2015;290:3865-74 pubmed publisher |
| Regazzetti C, Dumas K, Lacas Gervais S, Pastor F, Peraldi P, Bonnafous S, et al. Hypoxia inhibits Cavin-1 and Cavin-2 expression and down-regulates caveolae in adipocytes. Endocrinology. 2015;156:789-801 pubmed publisher |
| Shao C, Ahmad N, Hodges K, Kuang S, Ratliff T, Liu X. Inhibition of polo-like kinase 1 (Plk1) enhances the antineoplastic activity of metformin in prostate cancer. J Biol Chem. 2015;290:2024-33 pubmed publisher |
| Baida G, Bhalla P, Kirsanov K, Lesovaya E, Yakubovskaya M, Yuen K, et al. REDD1 functions at the crossroads between the therapeutic and adverse effects of topical glucocorticoids. EMBO Mol Med. 2015;7:42-58 pubmed publisher |
| Steiner J, Lang C. Sepsis attenuates the anabolic response to skeletal muscle contraction. Shock. 2015;43:344-51 pubmed publisher |
| Morquette B, Morquette P, Agostinone J, Feinstein E, McKinney R, Kolta A, et al. REDD2-mediated inhibition of mTOR promotes dendrite retraction induced by axonal injury. Cell Death Differ. 2015;22:612-25 pubmed publisher |
| Yang C, Matsuura K, Huang N, Robeson A, Huang B, Zhang L, et al. Fatty acid synthase inhibition engages a novel caspase-2 regulatory mechanism to induce ovarian cancer cell death. Oncogene. 2015;34:3264-72 pubmed publisher |
