This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
FASN
catalog :
10624-2-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 45
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 1
Bai J, Wang P, Liu Y, Zhang Y, Li Y, He Z, et al. Formaldehyde alters triglyceride synthesis and very low-density lipoprotein secretion in a time-dependent manner. Environ Toxicol Pharmacol. 2017;56:15-20 pubmed publisher
Chen W, Zhang X, Xu M, Jiang L, Zhou M, Liu W, et al. Betaine prevented high-fat diet-induced NAFLD by regulating the FGF10/AMPK signaling pathway in ApoE-/- mice. Eur J Nutr. 2020;: pubmed publisher
Zhang J, Yang J, Yang N, Ma J, Lu D, Dong Y, et al. Dlgap1 negatively regulates browning of white fat cells through effects on cell proliferation and apoptosis. Lipids Health Dis. 2020;19:39 pubmed publisher
Wang X, Du G, Wu Y, Zhang Y, Guo F, Liu W, et al. Association between different levels of lipid metabolism‑related enzymes and fatty acid synthase in Wilms' tumor. Int J Oncol. 2020;56:568-580 pubmed publisher
Gao P, Wang L, Liu J, Dong F, Song W, Liao L, et al. Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway. Life Sci. 2020;242:117221 pubmed publisher
Zhang Y, Zhou L, Zhang Z, Xu Q, Han X, Zhao Y, et al. Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5. Environ Sci Pollut Res Int. 2019;: pubmed publisher
Meng Z, Liu Q, Sun F, Qiao L. Hepatitis C virus nonstructural protein 5A perturbs lipid metabolism by modulating AMPK/SREBP-1c signaling. Lipids Health Dis. 2019;18:191 pubmed publisher
Zhang Y, Wang S, Zhao T, Yang L, Guo S, Shi Y, et al. Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells. Ecotoxicol Environ Saf. 2019;184:109611 pubmed publisher
Chen J, Zhou Y, Zhuang Y, Qin T, Guo M, Jiang J, et al. The metabolic regulator small heterodimer partner contributes to the glucose and lipid homeostasis abnormalities induced by hepatitis C virus infection. Metabolism. 2019;100:153954 pubmed publisher
Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, et al. Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1. EMBO Rep. 2019;:e48115 pubmed publisher
Liu M, Huang Y, Zhang T, Tan L, Lu X, Qin J. Lingguizhugan decoction attenuates diet-induced obesity and hepatosteatosis via gut microbiota. World J Gastroenterol. 2019;25:3590-3606 pubmed publisher
Yang N, Li C, Li H, Liu M, Cai X, Cao F, et al. Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells. Front Pharmacol. 2019;10:709 pubmed publisher
Zhang Y, Zhang Z, Zhou L, Zhu J, Zhang X, Qi W, et al. Di (2-ethylhexyl) phthalate Disorders Lipid Metabolism via TYK2/STAT1 and Autophagy in Rats. Biomed Environ Sci. 2019;32:406-418 pubmed publisher
Liu G, Kuang S, Cao R, Wang J, Peng Q, Sun C. Sorafenib kills liver cancer cells by disrupting SCD1-mediated synthesis of monounsaturated fatty acids via the ATP-AMPK-mTOR-SREBP1 signaling pathway. FASEB J. 2019;33:10089-10103 pubmed publisher
Luo M, Huang S, Zhang J, Zhang L, Mehmood K, Jiang J, et al. Effect of selenium nanoparticles against abnormal fatty acid metabolism induced by hexavalent chromium in chicken's liver. Environ Sci Pollut Res Int. 2019;: pubmed publisher
Yang H, Li J, Yang C, Liu H, Cao Y. Multi-walled carbon nanotubes promoted lipid accumulation in human aortic smooth muscle cells. Toxicol Appl Pharmacol. 2019;374:11-19 pubmed publisher
Bai J, He Z, Li Y, Jiang X, Yu H, Tan Q. Mono-2-ethylhexyl phthalate induces the expression of genes involved in fatty acid synthesis in HepG2 cells. Environ Toxicol Pharmacol. 2019;69:104-111 pubmed publisher
Wang Y, Guo D, He J, Song L, Chen H, Zhang Z, et al. Inhibition of fatty acid synthesis arrests colorectal neoplasm growth and metastasis: Anti-cancer therapeutical effects of natural cyclopeptide RA-XII. Biochem Biophys Res Commun. 2019;512:819-824 pubmed publisher
Wu K, Yin X, Jin Y, Liu F, Gao J. Identification of aberrantly methylated differentially expressed genes in prostate carcinoma using integrated bioinformatics. Cancer Cell Int. 2019;19:51 pubmed publisher
Yang C, Wang S, Ruan H, Li B, Cheng Z, He J, et al. Downregulation of PDK4 Increases Lipogenesis and Associates with Poor Prognosis in Hepatocellular Carcinoma. J Cancer. 2019;10:918-926 pubmed publisher
Wallace M, Green C, Roberts L, Lee Y, McCarville J, Sanchez Gurmaches J, et al. Enzyme promiscuity drives branched-chain fatty acid synthesis in adipose tissues. Nat Chem Biol. 2018;14:1021-1031 pubmed publisher
Wu J, Zheng M, Zhang M, Pang X, Li L, Wang S, et al. Porphyromonas gingivalis Promotes 4-Nitroquinoline-1-Oxide-Induced Oral Carcinogenesis With an Alteration of Fatty Acid Metabolism. Front Microbiol. 2018;9:2081 pubmed publisher
Trotman J, Agana B, Giltmier A, Wysocki V, Schoenberg D. RNA-binding proteins and heat-shock protein 90 are constituents of the cytoplasmic capping enzyme interactome. J Biol Chem. 2018;293:16596-16607 pubmed publisher
Li D, Tian G, Wang J, Zhao L, Co O, Underill Z, et al. Inhibition of androgen receptor transactivation function by adenovirus type 12 E1A undermines prostate cancer cell survival. Prostate. 2018;78:1140-1156 pubmed publisher
Qiao X, Li Y, Mai J, Ji X, Li Q. Effect of Dibutyltin Dilaurate on Triglyceride Metabolism through the Inhibition of the mTOR Pathway in Human HL7702 Liver Cells. Molecules. 2018;23: pubmed publisher
Li N, Li M, Hong W, Shao J, Xu H, Shimano H, et al. Brg1 regulates pro-lipogenic transcription by modulating SREBP activity in hepatocytes. Biochim Biophys Acta Mol Basis Dis. 2018;1864:2881-2889 pubmed publisher
Zhang W, Zhong W, Sun Q, Sun X, Zhou Z. Adipose-specific lipin1 overexpression in mice protects against alcohol-induced liver injury. Sci Rep. 2018;8:408 pubmed publisher
Chen S, Li X, Liu L, Liu C, Han X. Ophiopogonin D alleviates high-fat diet-induced metabolic syndrome and changes the structure of gut microbiota in mice. FASEB J. 2018;32:1139-1153 pubmed publisher
Duan X, Meng Q, Wang C, Liu Z, Sun H, Huo X, et al. Effects of calycosin against high-fat diet-induced nonalcoholic fatty liver disease in mice. J Gastroenterol Hepatol. 2018;33:533-542 pubmed publisher
Kiss D, Baez W, Huebner K, Bundschuh R, Schoenberg D. Impact of FHIT loss on the translation of cancer-associated mRNAs. Mol Cancer. 2017;16:179 pubmed publisher
Iwakoshi Ukena E, Shikano K, Kondo K, Taniuchi S, Furumitsu M, Ochi Y, et al. Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity. elife. 2017;6: pubmed publisher
Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, et al. Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission. EMBO J. 2017;36:1330-1347 pubmed publisher
Tang L, Wang J, Xu T, Zhao Z, Zheng J, Ge R, et al. Mitochondrial toxicity of perfluorooctane sulfonate in mouse embryonic stem cell-derived cardiomyocytes. Toxicology. 2017;382:108-116 pubmed publisher
Xue C, Wang C, Sun Y, Meng Q, Liu Z, Huo X, et al. Targeting P-glycoprotein function, p53 and energy metabolism: Combination of metformin and 2-deoxyglucose reverses the multidrug resistance of MCF-7/Dox cells to doxorubicin. Oncotarget. 2017;8:8622-8632 pubmed publisher
Wu L, Guo X, Hartson S, Davis M, He H, Medeiros D, et al. Lack of ?, ?-carotene-9', 10'-oxygenase 2 leads to hepatic mitochondrial dysfunction and cellular oxidative stress in mice. Mol Nutr Food Res. 2017;61: pubmed publisher
Luo D, Xiao H, Dong J, Li Y, Feng G, Cui M, et al. B7-H3 regulates lipid metabolism of lung cancer through SREBP1-mediated expression of FASN. Biochem Biophys Res Commun. 2017;482:1246-1251 pubmed publisher
Zhang Y, Yu H, Gao P, Chen J, Yu C, Zong C, et al. The Effect of Growth Hormone on Lipid Accumulation or Maturation in Adipocytes. Cell Physiol Biochem. 2016;39:2135-2148 pubmed
Meng Q, Duan X, Wang C, Liu Z, Sun P, Huo X, et al. Alisol B 23-acetate protects against non-alcoholic steatohepatitis in mice via farnesoid X receptor activation. Acta Pharmacol Sin. 2017;38:69-79 pubmed publisher
Yang W, She L, Yu K, Yan S, Zhang X, Tian X, et al. Jatrorrhizine hydrochloride attenuates hyperlipidemia in a high-fat diet-induced obesity mouse model. Mol Med Rep. 2016;14:3277-84 pubmed publisher
Xin M, Qiao Z, Li J, Liu J, Song S, Zhao X, et al. miR-22 inhibits tumor growth and metastasis by targeting ATP citrate lyase: evidence in osteosarcoma, prostate cancer, cervical cancer and lung cancer. Oncotarget. 2016;7:44252-44265 pubmed publisher
Wang H, Xi Q, Wu G. Fatty acid synthase regulates invasion and metastasis of colorectal cancer via Wnt signaling pathway. Cancer Med. 2016;5:1599-606 pubmed publisher
Wang M, Wu H, Fu G, Zhang H, Zhou X, Tang L, et al. Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients. Hepatology. 2016;63:1272-86 pubmed publisher
Cai D, Wang J, Jia Y, Liu H, Yuan M, Dong H, et al. Gestational dietary betaine supplementation suppresses hepatic expression of lipogenic genes in neonatal piglets through epigenetic and glucocorticoid receptor-dependent mechanisms. Biochim Biophys Acta. 2016;1861:41-50 pubmed publisher
Chen J, Ren J, Jing Q, Lu S, Zhang Y, Liu Y, et al. TSH/TSHR Signaling Suppresses Fatty Acid Synthase (FASN) Expression in Adipocytes. J Cell Physiol. 2015;230:2233-9 pubmed publisher
Cui M, Xiao Z, Wang Y, Zheng M, Song T, Cai X, et al. Long noncoding RNA HULC modulates abnormal lipid metabolism in hepatoma cells through an miR-9-mediated RXRA signaling pathway. Cancer Res. 2015;75:846-57 pubmed publisher
product information
CatalogNo :
10624-2-AP
AntigenName :
FASN
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
fatty acid synthase
Immunogen :
Recombinant Protein
Species :
chicken, human, mouse, pig, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, FC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
FAS, FASN, fatty acid synthase, OA 519, SDR27X1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC007909
Category :
Binding Proteins;Cytoskeleton/Scaffold Proteins;Disease Related;Membrane Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
FC 1:0 ; IF 1:25 ; IHC 1:200 ; IP 1:500 ; WB 1:300 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.