| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot; rat; 1:1000; loading ...; fig 4c
| Yang Y, Chen S, Tao L, Gan S, Luo H, Xu Y, et al. Inhibitory Effects of Oxymatrine on Transdifferentiation of Neonatal Rat Cardiac Fibroblasts to Myofibroblasts Induced by Aldosterone via Keap1/Nrf2 Signaling Pathways In Vitro. Med Sci Monit. 2019;25:5375-5388 pubmed publisher |
- western blot; mouse; loading ...; fig 6c
| Hos N, Ganesan R, Gutierrez S, Hos D, Klimek J, Abdullah Z, et al. Type I interferon enhances necroptosis of Salmonella Typhimurium-infected macrophages by impairing antioxidative stress responses. J Cell Biol. 2017;216:4107-4121 pubmed publisher |
- western blot; mouse; loading ...; fig 5a
| Ugun Klusek A, Tatham M, Elkharaz J, Constantin Teodosiu D, Lawler K, Mohamed H, et al. Continued 26S proteasome dysfunction in mouse brain cortical neurons impairs autophagy and the Keap1-Nrf2 oxidative defence pathway. Cell Death Dis. 2017;8:e2531 pubmed publisher |
- western blot; human; fig 5
| Park S, Han S, Choi I, Kim B, Park S, Joe E, et al. Interplay between Leucine-Rich Repeat Kinase 2 (LRRK2) and p62/SQSTM-1 in Selective Autophagy. PLoS ONE. 2016;11:e0163029 pubmed publisher |
- western blot; human; 1:1000; fig 1
| Tian Y, Wu K, Liu Q, Han N, Zhang L, Chu Q, et al. Modification of platinum sensitivity by KEAP1/NRF2 signals in non-small cell lung cancer. J Hematol Oncol. 2016;9:83 pubmed publisher |
- RNA immunoprecipitation; human; loading ...; fig 3d
- western blot; human; loading ...; fig 3e
| Sakurai T, Isogaya K, Sakai S, Morikawa M, Morishita Y, Ehata S, et al. RNA-binding motif protein 47 inhibits Nrf2 activity to suppress tumor growth in lung adenocarcinoma. Oncogene. 2016;35:5000-9 pubmed publisher |
| Sun B, Wang X, Liu X, Wang L, Ren F, Wang X, et al. Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2-KEAP1-CUL3 Interactions in Chronic Kidney Disease. Antioxidants (Basel). 2020;9: pubmed publisher |
| Wang T, Jian Z, Baskys A, Yang J, Li J, Guo H, et al. MSC-derived exosomes protect against oxidative stress-induced skin injury via adaptive regulation of the NRF2 defense system. Biomaterials. 2020;257:120264 pubmed publisher |
| Lu Y, Sun Y, Liu Z, Lu Y, Zhu X, Lan B, et al. Activation of NRF2 ameliorates oxidative stress and cystogenesis in autosomal dominant polycystic kidney disease. Sci Transl Med. 2020;12: pubmed publisher |
| Liu J, Hu Y, Feng Y, Jiang Y, Guo Y, Liu Y, et al. BDH2 triggers ROS-induced cell death and autophagy by promoting Nrf2 ubiquitination in gastric cancer. J Exp Clin Cancer Res. 2020;39:123 pubmed publisher |
| Tian Y, Liu Q, Yu S, Chu Q, Chen Y, Wu K, et al. NRF2-Driven KEAP1 Transcription in Human Lung Cancer. Mol Cancer Res. 2020;: pubmed publisher |
| Nordgren K, Wallace K. Disruption of the Keap1/Nrf2-Antioxidant Response System After Chronic Doxorubicin Exposure In Vivo. Cardiovasc Toxicol. 2020;: pubmed publisher |
| Chen X, Qi J, Wu Q, Jiang H, Wang J, Chen W, et al. High glucose inhibits vascular endothelial Keap1/Nrf2/ARE signal pathway via downregulation of monomethyltransferase SET8 expression. Acta Biochim Biophys Sin (Shanghai). 2020;52:506-516 pubmed publisher |
| Zhou H, Yuan D, Gao W, Tian J, Sun H, Yu S, et al. Loss of high-temperature requirement protein A2 protease activity induces mitonuclear imbalance via differential regulation of mitochondrial biogenesis in sarcopenia. IUBMB Life. 2020;72:1659-1679 pubmed publisher |
| Jiang Z, Fu L, Xu Y, Hu X, Yang H, Zhang Y, et al. Cyclovirobuxine D protects against diabetic cardiomyopathy by activating Nrf2-mediated antioxidant responses. Sci Rep. 2020;10:6427 pubmed publisher |
| Fan Y, Xing Y, Xiong L, Wang J. Sestrin2 overexpression alleviates hydrogen peroxide-induced apoptosis and oxidative stress in retinal ganglion cells by enhancing Nrf2 activation via Keap1 downregulation. Chem Biol Interact. 2020;324:109086 pubmed publisher |
| Wang S, Cheng H, Wang L, Zhao R, Guan D. Overexpression of NRF1-742 or NRF1-772 Reduces Arsenic-Induced Cytotoxicity and Apoptosis in Human HaCaT Keratinocytes. Int J Mol Sci. 2020;21: pubmed publisher |
| Wang Z, Cai L, Li H, Liang M, Zhang Y, Wu Q, et al. Rice protein stimulates endogenous antioxidant response attributed to methionine availability in growing rats. J Food Biochem. 2020;44:e13180 pubmed publisher |
| Mo M, Li S, Dong Z, Li C, Sun Y, Li A, et al. S-allylmercaptocysteine ameliorates lipopolysaccharide-induced acute lung injury in mice by inhibiting inflammation and oxidative stress via nuclear factor kappa B and Keap1/Nrf2 pathways. Int Immunopharmacol. 2020;81:106273 pubmed publisher |
| Deng S, Essandoh K, Wang X, Li Y, Huang W, Chen J, et al. Tsg101 positively regulates P62-Keap1-Nrf2 pathway to protect hearts against oxidative damage. Redox Biol. 2020;32:101453 pubmed publisher |
| Xu A, Yang Y, Shao Y, Wu M, Sun Y. Activation of cannabinoid receptor type 2-induced osteogenic differentiation involves autophagy induction and p62-mediated Nrf2 deactivation. Cell Commun Signal. 2020;18:9 pubmed publisher |
| Xu Q, Shi W, Lv P, Meng W, Mao G, Gong C, et al. Critical role of caveolin-1 in aflatoxin B1-induced hepatotoxicity via the regulation of oxidation and autophagy. Cell Death Dis. 2020;11:6 pubmed publisher |
| Lee D, Park J, Lee Y, Han J, Lee D, Kwon S, et al. SQSTM1/p62 activates NFE2L2/NRF2 via ULK1-mediated autophagic KEAP1 degradation and protects mouse liver from lipotoxicity. Autophagy. 2020;:1-25 pubmed publisher |
| Li G, Li A, Chen X, Zhang L, Wang T, Wang X, et al. Naturally-derived diterpenoid sphaeropsidin C as an activator of Nrf2/ARE pathway and its potential capability of relieving intracellular oxidative stress in human lung epithelial cells. Biomed Pharmacother. 2020;121:109669 pubmed publisher |
| Liu S, Xu S, Wei R, Cui Z, Wu X, Wei R, et al. Keap1 Cystenine 151 as a Potential Target for Artemisitene-Induced Nrf2 Activation. Biomed Res Int. 2019;2019:5198138 pubmed publisher |
| Zhang Y, Wang H, Zhang L, Yuan Y, Yu D. Codonopsis lanceolata polysaccharide CLPS alleviates high fat/high sucrose diet-induced insulin resistance via anti-oxidative stress. Int J Biol Macromol. 2019;: pubmed publisher |
| Shi Y, Fan S, Wu M, Zuo Z, Li X, Jiang L, et al. YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression. Nat Commun. 2019;10:4892 pubmed publisher |
| Xu B, Lang L, Lian S, Guo J, Wang J, Yang H, et al. Oxidation Stress-Mediated MAPK Signaling Pathway Activation Induces Neuronal Loss in the CA1 and CA3 Regions of the Hippocampus of Mice Following Chronic Cold Exposure. Brain Sci. 2019;9: pubmed publisher |
| Song S, Chu L, Liang H, Chen J, Liang J, Huang Z, et al. Protective Effects of Dioscin Against Doxorubicin-Induced Hepatotoxicity Via Regulation of Sirt1/FOXO1/NF-κb Signal. Front Pharmacol. 2019;10:1030 pubmed publisher |
| Zhang J, Cai W, Fan Z, Yang C, Wang W, Xiong M, et al. MicroRNA-24 inhibits the oxidative stress induced by vascular injury by activating the Nrf2/Ho-1 signaling pathway. Atherosclerosis. 2019;290:9-18 pubmed publisher |
| Xian P, Hei Y, Wang R, Wang T, Yang J, Li J, et al. Mesenchymal stem cell-derived exosomes as a nanotherapeutic agent for amelioration of inflammation-induced astrocyte alterations in mice. Theranostics. 2019;9:5956-5975 pubmed publisher |
| Deng Z, Lim J, Wang Q, Purtell K, Wu S, Palomo G, et al. ALS-FTLD-linked mutations of SQSTM1/p62 disrupt selective autophagy and NFE2L2/NRF2 anti-oxidative stress pathway. Autophagy. 2019;:1-15 pubmed publisher |
| Tocmo R, Parkin K. S-1-propenylmercaptocysteine protects murine hepatocytes against oxidative stress via persulfidation of Keap1 and activation of Nrf2. Free Radic Biol Med. 2019;143:164-175 pubmed publisher |
| Wu X, Chen X, Zhou M, Hu H, Zhang J, Wang X, et al. Artocarmitin B enhances intracellular antioxidant capacity via activation of Nrf2 signaling pathway in human lung epithelial cells. Chem Biol Interact. 2019;310:108741 pubmed publisher |
| Bao F, Tao L, Zhang H. Neuroprotective Effect of Natural Alkaloid Fangchinoline Against Oxidative Glutamate Toxicity: Involvement of Keap1-Nrf2 Axis Regulation. Cell Mol Neurobiol. 2019;: pubmed publisher |
| Lignitto L, LeBoeuf S, Homer H, Jiang S, Askenazi M, Karakousi T, et al. Nrf2 Activation Promotes Lung Cancer Metastasis by Inhibiting the Degradation of Bach1. Cell. 2019;: pubmed publisher |
| Liang M, Li H, Wang Z, Cai L, Yang L. Rice protein reduces DNA damage by activating the p53 pathway and stimulating endogenous antioxidant response in growing and adult rats. J Sci Food Agric. 2019;: pubmed publisher |
| Yan X, Fu X, Jia Y, Ma X, Tao J, Yang T, et al. Nrf2/Keap1/ARE Signaling Mediated an Antioxidative Protection of Human Placental Mesenchymal Stem Cells of Fetal Origin in Alveolar Epithelial Cells. Oxid Med Cell Longev. 2019;2019:2654910 pubmed publisher |
| Xu B, Lang L, Li S, Guo J, Wang J, Wang D, et al. Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure. Cells. 2019;8: pubmed publisher |
| Betharia S, Rondόn Ortiz A, Brown D. Disubstituted Dithiolethione ACDT Exerts Neuroprotective Effects Against 6-Hydroxydopamine-Induced Oxidative Stress in SH-SY5Y Cells. Neurochem Res. 2019;: pubmed publisher |
| Wang Z, Chen Z, Jiang Z, Luo P, Liu L, Huang Y, et al. Cordycepin prevents radiation ulcer by inhibiting cell senescence via NRF2 and AMPK in rodents. Nat Commun. 2019;10:2538 pubmed publisher |
| Li A, Shen T, Wang T, Zhou M, Wang B, Song J, et al. Novel diterpenoid-type activators of the Keap1/Nrf2/ARE signaling pathway and their regulation of redox homeostasis. Free Radic Biol Med. 2019;141:21-33 pubmed publisher |
| Peng D, Lu H, Zhu S, Zhou Z, Hu T, Chen Z, et al. NRF2 antioxidant response protects against acidic bile salts-induced oxidative stress and DNA damage in esophageal cells. Cancer Lett. 2019;458:46-55 pubmed publisher |
| Sparaneo A, Fabrizio F, la Torre A, Graziano P, Di Maio M, Fontana A, et al. Effects of KEAP1 Silencing on the Regulation of NRF2 Activity in Neuroendocrine Lung Tumors. Int J Mol Sci. 2019;20: pubmed publisher |
| Zhao X, Jin Y, Li L, Xu L, Tang Z, Qi Y, et al. MicroRNA-128-3p aggravates doxorubicin-induced liver injury by promoting oxidative stress via targeting Sirtuin-1. Pharmacol Res. 2019;146:104276 pubmed publisher |
| Kukoyi A, Fan X, Staitieh B, Hybertson B, Gao B, McCord J, et al. MiR-144 mediates Nrf2 inhibition and alveolar epithelial dysfunction in HIV-1 transgenic rats. Am J Physiol Cell Physiol. 2019;: pubmed publisher |
| Yan J, Pang Y, Zhuang J, Lin H, Zhang Q, Han L, et al. Selenepezil, a Selenium-Containing Compound, Exerts Neuroprotective Effect via Modulation of the Keap1-Nrf2-ARE Pathway and Attenuates Aβ-Induced Cognitive Impairment in Vivo. ACS Chem Neurosci. 2019;: pubmed publisher |
| Park J, Lee Y, Lee D, Bae S. Repositioning of niclosamide ethanolamine (NEN), an anthelmintic drug, for the treatment of lipotoxicity. Free Radic Biol Med. 2019;137:143-157 pubmed publisher |
| Ast T, Meisel J, Patra S, Wang H, Grange R, Kim S, et al. Hypoxia Rescues Frataxin Loss by Restoring Iron Sulfur Cluster Biogenesis. Cell. 2019;: pubmed publisher |
| Jia Y, Peng Y, Zhao Y, Cheng X, Zhou Y, Chai C, et al. Comparison of the Hepatoprotective Effects of the Three Main Stilbenes from Mulberry Twigs. J Agric Food Chem. 2019;: pubmed publisher |
| Zhang B, Wang G, He J, Yang Q, Li D, Li J, et al. Icariin attenuates neuroinflammation and exerts dopamine neuroprotection via an Nrf2-dependent manner. J Neuroinflammation. 2019;16:92 pubmed publisher |
| Wang Z, Liang M, Li H, Cai L, He H, Wu Q, et al. l-Methionine activates Nrf2-ARE pathway to induce endogenous antioxidant activity for depressing ROS-derived oxidative stress in growing rats. J Sci Food Agric. 2019;99:4849-4862 pubmed publisher |
| Hu T, Schreiter F, Bagchi R, Tatman P, Hannink M, McKinsey T. HDAC5 catalytic activity suppresses cardiomyocyte oxidative stress and NRF2 target gene expression. J Biol Chem. 2019;294:8640-8652 pubmed publisher |
| Qi Y, Li R, Xu L, Yin L, Xu Y, Han X, et al. Neuroprotective Effect of Dioscin on the Aging Brain. Molecules. 2019;24: pubmed publisher |
| Yamada M, Iwata M, Warabi E, Oishi H, Lira V, Okutsu M. p62/SQSTM1 and Nrf2 are essential for exercise-mediated enhancement of antioxidant protein expression in oxidative muscle. FASEB J. 2019;:fj201900133R pubmed publisher |
| Park J, Lee D, Lee Y, Oh E, Bae K, Oh K, et al. Dual roles of ULK1 (unc-51 like autophagy activating kinase 1) in cytoprotection against lipotoxicity. Autophagy. 2019;:1-20 pubmed publisher |
| Zhang B, Wu J, Cai Y, Luo M, Wang B, Gu Y. TCF7L1 indicates prognosis and promotes proliferation through activation of Keap1/NRF2 in gastric cancer. Acta Biochim Biophys Sin (Shanghai). 2019;51:375-385 pubmed publisher |
| Wang P, Geng J, Gao J, Zhao H, Li J, Shi Y, et al. Macrophage achieves self-protection against oxidative stress-induced ageing through the Mst-Nrf2 axis. Nat Commun. 2019;10:755 pubmed publisher |
| Wang H, Wei W, Lan X, Liu N, Li Y, Ma H, et al. Neuroprotective Effect of Swertiamain on Cerebral Ischemia/Reperfusion Injury by Inducing the Nrf2 Protective Pathway. ACS Chem Neurosci. 2019;10:2276-2286 pubmed publisher |
| Zhou X, Zhu C, Wu Z, Guo X, Zou W. The oncoprotein HBXIP competitively binds KEAP1 to activate NRF2 and enhance breast cancer cell growth and metastasis. Oncogene. 2019;38:4028-4046 pubmed publisher |
| Karras P, Riveiro Falkenbach E, Cañón E, Tejedo C, Calvo T, Martínez Herranz R, et al. p62/SQSTM1 Fuels Melanoma Progression by Opposing mRNA Decay of a Selective Set of Pro-metastatic Factors. Cancer Cell. 2019;35:46-63.e10 pubmed publisher |
| Yang Q, Lin J, Zhang H, Liu Y, Kan M, Xiu Z, et al. Ginsenoside Compound K Regulates Amyloid β via the Nrf2/Keap1 Signaling Pathway in Mice with Scopolamine Hydrobromide-Induced Memory Impairments. J Mol Neurosci. 2019;67:62-71 pubmed publisher |
| Qiao Y, Sun Y, Shen T, Zhang J, Zhou J, Li Y, et al. Diterpenoids from the Chinese liverwort Frullania hamatiloba and their Nrf2 inducing activities. Phytochemistry. 2019;158:77-85 pubmed publisher |
| Ullah O, Li Z, Ali I, Xu L, Liu H, Shah S, et al. Pterostilbene alleviates hydrogen peroxide-induced oxidative stress via nuclear factor erythroid 2 like 2 pathway in mouse preimplantation embryos. J Reprod Dev. 2019;65:73-81 pubmed publisher |
| Beneduce E, Matte A, De Falco L, Mbiandjeu S, Chiabrando D, Tolosano E, et al. Fyn kinase is a novel modulator of erythropoietin signaling and stress erythropoiesis. Am J Hematol. 2019;94:10-20 pubmed publisher |
| Kanamoto M, Tsuchiya Y, Nakao Y, Suzuki T, Motohashi H, Yamamoto M, et al. Structural instability of IκB kinase β promotes autophagic degradation through enhancement of Keap1 binding. PLoS ONE. 2018;13:e0203978 pubmed publisher |
| Cai J, Pires K, Ferhat M, Chaurasia B, Buffolo M, Smalling R, et al. Autophagy Ablation in Adipocytes Induces Insulin Resistance and Reveals Roles for Lipid Peroxide and Nrf2 Signaling in Adipose-Liver Crosstalk. Cell Rep. 2018;25:1708-1717.e5 pubmed publisher |
| Shin D, Kim E, Lee J, Roh J. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018;129:454-462 pubmed publisher |
| Li Y, Fu S, Li E, Sun X, Xu H, Meng Y, et al. Modulation of autophagy in the protective effect of resveratrol on PM2.5-induced pulmonary oxidative injury in mice. Phytother Res. 2018;32:2480-2486 pubmed publisher |
| Li Y, Li G, Zhou M, Xiang L, Ren D, Lou H, et al. Discovery of natural flavonoids as activators of Nrf2-mediated defense system: Structure-activity relationship and inhibition of intracellular oxidative insults. Bioorg Med Chem. 2018;26:5140-5150 pubmed publisher |
| Eckhardt M, Zhang W, Gross A, Von Dollen J, Johnson J, Franks Skiba K, et al. Multiple Routes to Oncogenesis Are Promoted by the Human Papillomavirus-Host Protein Network. Cancer Discov. 2018;8:1474-1489 pubmed publisher |
| Cloer E, Siesser P, Cousins E, Goldfarb D, Mowrey D, Harrison J, et al. p62-Dependent Phase Separation of Patient-Derived KEAP1 Mutations and NRF2. Mol Cell Biol. 2018;38: pubmed publisher |
| Zhang X, Li X, Fang J, Hou X, Fang H, Guo F, et al. (2R,3R)Dihydromyricetin inhibits osteoclastogenesis and bone loss through scavenging LPS-induced oxidative stress and NF-κB and MAPKs pathways activating. J Cell Biochem. 2018;119:8981-8995 pubmed publisher |
| Ning C, Gao X, Wang C, Kong Y, Liu Z, Sun H, et al. Ginsenoside Rg1 protects against acetaminophen-induced liver injury via activating Nrf2 signaling pathway in vivo and in vitro. Regul Toxicol Pharmacol. 2018;98:58-68 pubmed publisher |
| Prestigiacomo V, Suter Dick L. Nrf2 protects stellate cells from Smad-dependent cell activation. PLoS ONE. 2018;13:e0201044 pubmed publisher |
| Yamada T, Murata D, Adachi Y, Itoh K, Kameoka S, Igarashi A, et al. Mitochondrial Stasis Reveals p62-Mediated Ubiquitination in Parkin-Independent Mitophagy and Mitigates Nonalcoholic Fatty Liver Disease. Cell Metab. 2018;28:588-604.e5 pubmed publisher |
| Endo H, Owada S, Inagaki Y, Shida Y, Tatemichi M. Glucose starvation induces LKB1-AMPK-mediated MMP-9 expression in cancer cells. Sci Rep. 2018;8:10122 pubmed publisher |
| Yang B, Cheng H, Wang L, Fu J, Zhang G, Guan D, et al. Protective roles of NRF2 signaling pathway in cobalt chloride-induced hypoxic cytotoxicity in human HaCaT keratinocytes. Toxicol Appl Pharmacol. 2018;355:189-197 pubmed publisher |
| Hassannia B, Wiernicki B, Ingold I, Qu F, Van Herck S, Tyurina Y, et al. Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma. J Clin Invest. 2018;128:3341-3355 pubmed publisher |
| Cai S, Hou N, Zhao G, Liu X, He Y, Liu H, et al. Nrf2 Is a Key Regulator on Puerarin Preventing Cardiac Fibrosis and Upregulating Metabolic Enzymes UGT1A1 in Rats. Front Pharmacol. 2018;9:540 pubmed publisher |
| Liu J, Li W, Limbu M, Li Y, Wang Z, Cheng Z, et al. Effects of Simultaneous Downregulation of PHD1 and Keap1 on Prevention and Reversal of Liver Fibrosis in Mice. Front Pharmacol. 2018;9:555 pubmed publisher |
| Adams O, Janser F, Dislich B, Berezowska S, Humbert M, Seiler C, et al. A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas. PLoS ONE. 2018;13:e0197610 pubmed publisher |
| Li Y, Qian W, Wang D, Meng Y, Wang X, Chen Y, et al. Resveratrol relieves particulate matter (mean diameter < 2.5 ?m)-induced oxidative injury of lung cells through attenuation of autophagy deregulation. J Appl Toxicol. 2018;38:1251-1261 pubmed publisher |
| Chen J, Ou Y, Yang Y, Li W, Xu Y, Xie Y, et al. KLHL22 activates amino-acid-dependent mTORC1 signalling to promote tumorigenesis and ageing. Nature. 2018;557:585-589 pubmed publisher |
| Li Y, Li G, Sun L, Li L, Liu Y, Kong D, et al. Ingredients from Litsea garrettii as Potential Preventive Agents against Oxidative Insult and Inflammatory Response. Oxid Med Cell Longev. 2018;2018:7616852 pubmed publisher |
| Hu Q, Qin Y, Xiang J, Liu W, Xu W, Sun Q, et al. dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer. Cell Prolif. 2018;51:e12456 pubmed publisher |
| Bi W, He C, Li X, Zhou L, Liu R, Zhang S, et al. Ginnalin A from Kujin tea (Acer tataricum subsp. ginnala) exhibits a colorectal cancer chemoprevention effect via activation of the Nrf2/HO-1 signaling pathway. Food Funct. 2018;9:2809-2819 pubmed publisher |
| Zhang J, Jiao Q, Kong L, Yu J, Fang A, Li M, et al. Nrf2 and Keap1 abnormalities in esophageal squamous cell carcinoma and association with the effect of chemoradiotherapy. Thorac Cancer. 2018;9:726-735 pubmed publisher |
| Zhou M, Zhang W, Li R, Guo C, Wei S, Tian X, et al. Anti-inflammatory activity of Khayandirobilide A from Khaya senegalensis via NF-?B, AP-1 and p38 MAPK/Nrf2/HO-1 signaling pathways in lipopolysaccharide-stimulated RAW 264.7 and BV-2 cells. Phytomedicine. 2018;42:152-163 pubmed publisher |
| Liang M, Wang Z, Li H, Cai L, Pan J, He H, et al. l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway. Food Chem Toxicol. 2018;115:315-328 pubmed publisher |
| Zhao L, Tao X, Qi Y, Xu L, Yin L, Peng J. Protective effect of dioscin against doxorubicin-induced cardiotoxicity via adjusting microRNA-140-5p-mediated myocardial oxidative stress. Redox Biol. 2018;16:189-198 pubmed publisher |
| Zhao D, Badur M, Luebeck J, Magaña J, Birmingham A, Sasik R, et al. Combinatorial CRISPR-Cas9 Metabolic Screens Reveal Critical Redox Control Points Dependent on the KEAP1-NRF2 Regulatory Axis. Mol Cell. 2018;69:699-708.e7 pubmed publisher |
| Jia Y, Lu H, Peng Y, Zhang B, Gong X, Su J, et al. Oxyresveratrol prevents lipopolysaccharide/d-galactosamine-induced acute liver injury in mice. Int Immunopharmacol. 2018;56:105-112 pubmed publisher |
| Lu M, Liu T, Jiao Q, Ji J, Tao M, Liu Y, et al. Discovery of a Keap1-dependent peptide PROTAC to knockdown Tau by ubiquitination-proteasome degradation pathway. Eur J Med Chem. 2018;146:251-259 pubmed publisher |
| Kageyama S, Saito T, Obata M, Koide R, Ichimura Y, Komatsu M. Negative Regulation of the Keap1-Nrf2 Pathway by a p62/Sqstm1 Splicing Variant. Mol Cell Biol. 2018;38: pubmed publisher |
| Shen Z, Wang Y, Su Z, Kou R, Xie K, Song F. Activation of p62-keap1-Nrf2 antioxidant pathway in the early stage of acetaminophen-induced acute liver injury in mice. Chem Biol Interact. 2018;282:22-28 pubmed publisher |
| Li S, Dai Q, Zhang S, Liu Y, Yu Q, Tan F, et al. Ulinastatin attenuates LPS-induced inflammation in mouse macrophage RAW264.7 cells by inhibiting the JNK/NF-κB signaling pathway and activating the PI3K/Akt/Nrf2 pathway. Acta Pharmacol Sin. 2018;39:1294-1304 pubmed publisher |
| Gong W, Chen Z, Zou Y, Zhang L, Huang J, Liu P, et al. CKIP-1 affects the polyubiquitination of Nrf2 and Keap1 via mediating Smurf1 to resist HG-induced renal fibrosis in GMCs and diabetic mice kidneys. Free Radic Biol Med. 2018;115:338-350 pubmed publisher |
| An H, Harper J. Systematic analysis of ribophagy in human cells reveals bystander flux during selective autophagy. Nat Cell Biol. 2018;20:135-143 pubmed publisher |
| Qiao Y, Xu L, Tao X, Yin L, Qi Y, Xu Y, et al. Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation. Toxicol Lett. 2018;284:37-45 pubmed publisher |
| Lin E, Bayarsengee U, Wang C, Chiang Y, Cheng C. The natural compound 2,3,5,4'-tetrahydroxystilbene-2-O-β-d glucoside protects against adriamycin-induced nephropathy through activating the Nrf2-Keap1 antioxidant pathway. Environ Toxicol. 2018;33:72-82 pubmed publisher |
| Zhou M, Li G, Sun B, Xu Y, Li A, Li Y, et al. Identification of novel Nrf2 activators from Cinnamomum chartophyllum H.W. Li and their potential application of preventing oxidative insults in human lung epithelial cells. Redox Biol. 2018;14:154-163 pubmed publisher |
| Huang R, Li X, Yu Y, Ma L, Liu S, Zong X, et al. SETD7 is a prognosis predicting factor of breast cancer and regulates redox homeostasis. Oncotarget. 2017;8:94080-94090 pubmed publisher |
| Ge W, Zhao K, Wang X, Li H, Yu M, He M, et al. iASPP Is an Antioxidative Factor and Drives Cancer Growth and Drug Resistance by Competing with Nrf2 for Keap1 Binding. Cancer Cell. 2017;32:561-573.e6 pubmed publisher |
| Huang K, Gao X, Wei W. The crosstalk between Sirt1 and Keap1/Nrf2/ARE anti-oxidative pathway forms a positive feedback loop to inhibit FN and TGF-?1 expressions in rat glomerular mesangial cells. Exp Cell Res. 2017;361:63-72 pubmed publisher |
| Anzovino A, Chiang S, Brown B, Hawkins C, Richardson D, Huang M. Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated via Upregulation of Keap1 and Activation of the Gsk3? Axis. Am J Pathol. 2017;187:2858-2875 pubmed publisher |
| O Mealey G, Plafker K, Berry W, Janknecht R, Chan J, Plafker S. A PGAM5-KEAP1-Nrf2 complex is required for stress-induced mitochondrial retrograde trafficking. J Cell Sci. 2017;130:3467-3480 pubmed publisher |
| Mildenberger J, Johansson I, Sergin I, Kjøbli E, Damas J, Razani B, et al. N-3 PUFAs induce inflammatory tolerance by formation of KEAP1-containing SQSTM1/p62-bodies and activation of NFE2L2. Autophagy. 2017;13:1664-1678 pubmed publisher |
| Wu J, Tian Z, Sun Y, Lu C, Liu N, Gao Z, et al. Exogenous H2S facilitating ubiquitin aggregates clearance via autophagy attenuates type 2 diabetes-induced cardiomyopathy. Cell Death Dis. 2017;8:e2992 pubmed publisher |
| Akdemir B, Nakajima Y, Inazawa J, Inoue J. miR-432 Induces NRF2 Stabilization by Directly Targeting KEAP1. Mol Cancer Res. 2017;15:1570-1578 pubmed publisher |
| Liu J, Li Y, Liu L, Wang Z, Shi C, Cheng Z, et al. Double Knockdown of PHD1 and Keap1 Attenuated Hypoxia-Induced Injuries in Hepatocytes. Front Physiol. 2017;8:291 pubmed publisher |
| Wang Q, Ma J, Lu Y, Zhang S, Huang J, Bei J, et al. CDK20 interacts with KEAP1 to activate NRF2 and promotes radiochemoresistance in lung cancer cells. Oncogene. 2017;36:5321-5330 pubmed publisher |
| Arai A, Chano T, Ikebuchi K, Hama Y, Ochi Y, Tameno H, et al. p62/SQSTM1 levels predicts radiotherapy resistance in hypopharyngeal carcinomas. Am J Cancer Res. 2017;7:881-891 pubmed |
| Gong W, Li J, Chen Z, Huang J, Chen Q, Cai W, et al. Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating CKIP-1 to resist HG-induced up-regulation of FN and ICAM-1 in GMCs and diabetic mice kidneys. Free Radic Biol Med. 2017;106:393-405 pubmed publisher |
| Krall E, Wang B, Munoz D, Ilic N, Raghavan S, Niederst M, et al. KEAP1 loss modulates sensitivity to kinase targeted therapy in lung cancer. elife. 2017;6: pubmed publisher |
| Fabrizio F, Costantini M, Copetti M, la Torre A, Sparaneo A, Fontana A, et al. Keap1/Nrf2 pathway in kidney cancer: frequent methylation of KEAP1 gene promoter in clear renal cell carcinoma. Oncotarget. 2017;8:11187-11198 pubmed publisher |
| Xiao L, Xu X, Zhang F, Wang M, Xu Y, Tang D, et al. The mitochondria-targeted antioxidant MitoQ ameliorated tubular injury mediated by mitophagy in diabetic kidney disease via Nrf2/PINK1. Redox Biol. 2017;11:297-311 pubmed publisher |
| Nlandu Khodo S, Dissard R, Hasler U, Schafer M, Pircher H, Jansen Durr P, et al. NADPH oxidase 4 deficiency increases tubular cell death during acute ischemic reperfusion injury. Sci Rep. 2016;6:38598 pubmed publisher |
| O Mealey G, Berry W, Plafker S. Sulforaphane is a Nrf2-independent inhibitor of mitochondrial fission. Redox Biol. 2017;11:103-110 pubmed publisher |
| Duleh S, Wang X, Komirenko A, Margeta M. Activation of the Keap1/Nrf2 stress response pathway in autophagic vacuolar myopathies. Acta Neuropathol Commun. 2016;4:115 pubmed |
| Park J, Oh S, Lee D, Lee Y, Sung S, Ji H, et al. p62/SQSTM1 is required for the protection against endoplasmic reticulum stress-induced apoptotic cell death. Free Radic Res. 2016;50:1408-1421 pubmed |
| Lee D, Han D, Nam K, Park J, Kim S, Lee M, et al. Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis. Free Radic Biol Med. 2016;99:520-532 pubmed publisher |
| Mulvaney K, Matson J, Siesser P, Tamir T, Goldfarb D, Jacobs T, et al. Identification and Characterization of MCM3 as a Kelch-like ECH-associated Protein 1 (KEAP1) Substrate. J Biol Chem. 2016;291:23719-23733 pubmed |
| Wang S, Chen Y, Kou R, Wang Y, Zeng T, Xie K, et al. Carbon disulfide activates p62-Nrf2-keap1 pathway in rat nerve tissues. Toxicology. 2016;368-369:19-27 pubmed publisher |
| Gong W, Chen C, Xiong F, Yang Z, Wang Y, Huang J, et al. CKIP-1 ameliorates high glucose-induced expression of fibronectin and intercellular cell adhesion molecule-1 by activating the Nrf2/ARE pathway in glomerular mesangial cells. Biochem Pharmacol. 2016;116:140-52 pubmed publisher |
| Zhao L, Xu L, Tao X, Han X, Yin L, Qi Y, et al. Protective Effect of the Total Flavonoids from Rosa laevigata Michx Fruit on Renal Ischemia-Reperfusion Injury through Suppression of Oxidative Stress and Inflammation. Molecules. 2016;21: pubmed publisher |
| Tao X, Sun X, Xu L, Yin L, Han X, Qi Y, et al. Total Flavonoids from Rosa laevigata Michx Fruit Ameliorates Hepatic Ischemia/Reperfusion Injury through Inhibition of Oxidative Stress and Inflammation in Rats. Nutrients. 2016;8: pubmed publisher |
| Saito T, Ichimura Y, Taguchi K, Suzuki T, Mizushima T, Takagi K, et al. p62/Sqstm1 promotes malignancy of HCV-positive hepatocellular carcinoma through Nrf2-dependent metabolic reprogramming. Nat Commun. 2016;7:12030 pubmed publisher |
| Sergin I, Bhattacharya S, Emanuel R, Esen E, Stokes C, Evans T, et al. Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis. Sci Signal. 2016;9:ra2 pubmed publisher |
| Eino A, Kageyama S, Uemura T, Annoh H, Saito T, Narita I, et al. Sqstm1-GFP knock-in mice reveal dynamic actions of Sqstm1 during autophagy and under stress conditions in living cells. J Cell Sci. 2015;128:4453-61 pubmed publisher |
| Park J, Kang D, Lee D, Bae S. PF-4708671, a specific inhibitor of p70 ribosomal S6 kinase 1, activates Nrf2 by promoting p62-dependent autophagic degradation of Keap1. Biochem Biophys Res Commun. 2015;466:499-504 pubmed publisher |
| Park J, Kang D, Lee D, Bae S. Concerted action of p62 and Nrf2 protects cells from palmitic acid-induced lipotoxicity. Biochem Biophys Res Commun. 2015;466:131-7 pubmed publisher |
| Probst B, McCauley L, Treviño I, Wigley W, Ferguson D. Cancer Cell Growth Is Differentially Affected by Constitutive Activation of NRF2 by KEAP1 Deletion and Pharmacological Activation of NRF2 by the Synthetic Triterpenoid, RTA 405. PLoS ONE. 2015;10:e0135257 pubmed publisher |
| Park J, Kang D, Lee D, Bae S. Fenofibrate activates Nrf2 through p62-dependent Keap1 degradation. Biochem Biophys Res Commun. 2015;465:542-7 pubmed publisher |
| Park J, Kang D, Bae S. p62 prevents carbonyl cyanide m-chlorophenyl hydrazine (CCCP)-induced apoptotic cell death by activating Nrf2. Biochem Biophys Res Commun. 2015;464:1139-1144 pubmed publisher |
| Awuh J, Haug M, Mildenberger J, Marstad A, Do C, Louet C, et al. Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages. Proc Natl Acad Sci U S A. 2015;112:E4272-80 pubmed publisher |
| Bakkar N, Kousari A, Kovalik T, Li Y, Bowser R. RBM45 Modulates the Antioxidant Response in Amyotrophic Lateral Sclerosis through Interactions with KEAP1. Mol Cell Biol. 2015;35:2385-99 pubmed publisher |
| Zhang X, Han X, Yin L, Xu L, Qi Y, Xu Y, et al. Potent effects of dioscin against liver fibrosis. Sci Rep. 2015;5:9713 pubmed publisher |
| Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, et al. Potent effects of dioscin against obesity in mice. Sci Rep. 2015;5:7973 pubmed publisher |
| Tanji K, Odagiri S, Miki Y, Maruyama A, Nikaido Y, Mimura J, et al. p62 Deficiency Enhances α-Synuclein Pathology in Mice. Brain Pathol. 2015;25:552-64 pubmed publisher |
| Huang K, Chen C, Hao J, Huang J, Wang S, Liu P, et al. Polydatin promotes Nrf2-ARE anti-oxidative pathway through activating Sirt1 to resist AGEs-induced upregulation of fibronetin and transforming growth factor-β1 in rat glomerular messangial cells. Mol Cell Endocrinol. 2015;399:178-89 pubmed publisher |
