Published Application/Species/Sample/Dilution | Reference |
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- western blot; mouse; loading ...; fig 1b
| Smith H, Freeman O, Butcher A, Holmqvist S, Humoud I, Schätzl T, et al. Astrocyte Unfolded Protein Response Induces a Specific Reactivity State that Causes Non-Cell-Autonomous Neuronal Degeneration. Neuron. 2020;: pubmed publisher
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- western blot; mouse; loading ...; fig 3a
| Sun Y, Liu Z, Cao X, Lu Y, Mi Z, He C, et al. Activation of P-TEFb by cAMP-PKA signaling in autosomal dominant polycystic kidney disease. Sci Adv. 2019;5:eaaw3593 pubmed publisher
|
- western blot; hamsters; loading ...; fig 11a
| Crespillo Casado A, Chambers J, Fischer P, Marciniak S, Ron D. PPP1R15A-mediated dephosphorylation of eIF2α is unaffected by Sephin1 or Guanabenz. elife. 2017;6: pubmed publisher
|
| Young Baird S, Lourenço M, Elder M, Klann E, Liebau S, Dever T. Suppression of MEHMO Syndrome Mutation in eIF2 by Small Molecule ISRIB. Mol Cell. 2019;: pubmed publisher
|
| Ishaq M, Marshall H, Natarajan V. GADD34 attenuates HIV-1 replication by viral 5'-UTR TAR RNA-mediated translational inhibition. Virology. 2019;540:119-131 pubmed publisher
|
| Gao P, Chai Y, Song J, Liu T, Chen P, Zhou L, et al. Reprogramming the unfolded protein response for replication by porcine reproductive and respiratory syndrome virus. PLoS Pathog. 2019;15:e1008169 pubmed publisher
|
| Sicari D, Delaunay Moisan A, Combettes L, Chevet E, Igbaria A. A guide to assessing endoplasmic reticulum homeostasis and stress in mammalian systems. FEBS J. 2019;: pubmed publisher
|
| Tang Q, Ren L, Liu J, Li W, Zheng X, Wang J, et al. Withaferin A triggers G2/M arrest and intrinsic apoptosis in glioblastoma cells via ATF4-ATF3-CHOP axis. Cell Prolif. 2019;:e12706 pubmed publisher
|
| Samluk L, Urbanska M, Kisielewska K, Mohanraj K, Kim M, Machnicka K, et al. Cytosolic translational responses differ under conditions of severe short-term and long-term mitochondrial stress. Mol Biol Cell. 2019;:mbcE18100628 pubmed publisher
|
| Patel V, Bidault G, Chambers J, Carobbio S, Everden A, Garcés C, et al. Inactivation of Ppp1r15a minimises weight gain and insulin resistance during caloric excess in female mice. Sci Rep. 2019;9:2903 pubmed publisher
|
| Peng X, Yang T, He L, Chen X, Jiang Y, Zhang H, et al. Impact of GADD34 on Apoptosis of Tonsillar Mononuclear Cells from IgA Nephropathy Patients by Regulating Eif2α Phosphorylation. Cell Physiol Biochem. 2018;50:2203-2215 pubmed publisher
|
| Dolinay T, Aonbangkhen C, Zacharias W, Cantu E, Pogoriler J, Stablow A, et al. Protein kinase R-like endoplasmatic reticulum kinase is a mediator of stretch in ventilator-induced lung injury. Respir Res. 2018;19:157 pubmed publisher
|
| Chang T, Lawrence D, Lu M, Tan J, Harnoss J, Marsters S, et al. Coordination between Two Branches of the Unfolded Protein Response Determines Apoptotic Cell Fate. Mol Cell. 2018;71:629-636.e5 pubmed publisher
|
| Krzyzosiak A, Sigurdardottir A, Luh L, Carrara M, Das I, Schneider K, et al. Target-Based Discovery of an Inhibitor of the Regulatory Phosphatase PPP1R15B. Cell. 2018;174:1216-1228.e19 pubmed publisher
|
| Moon S, Parker R. EIF2B2 mutations in vanishing white matter disease hypersuppress translation and delay recovery during the integrated stress response. RNA. 2018;24:841-852 pubmed publisher
|
| Melas P, Qvist J, Deidda M, Upreti C, Wei Y, Sanna F, et al. Cannabinoid Modulation of Eukaryotic Initiation Factors (eIF2α and eIF2B1) and Behavioral Cross-Sensitization to Cocaine in Adolescent Rats. Cell Rep. 2018;22:2909-2923 pubmed publisher
|
| Baird T, Cheng K, Chen Y, Buehler E, Martin S, Inglese J, et al. ICE1 promotes the link between splicing and nonsense-mediated mRNA decay. elife. 2018;7: pubmed publisher
|
| Sun X, Aimé P, Dai D, Ramalingam N, Crary J, Burke R, et al. Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease. Exp Neurol. 2018;303:95-107 pubmed publisher
|
| Hyer M, Milhollen M, Ciavarri J, Fleming P, Traore T, Sappal D, et al. A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment. Nat Med. 2018;24:186-193 pubmed publisher
|
| Collier A, Spandau D, Wek R. Translational control of a human CDKN1A mRNA splice variant regulates the fate of UVB-irradiated human keratinocytes. Mol Biol Cell. 2018;29:29-41 pubmed publisher
|
| Lee I, Ho X, George S, Goh C, Sundaram J, Pang K, et al. Oxidative stress promotes SIRT1 recruitment to the GADD34/PP1α complex to activate its deacetylase function. Cell Death Differ. 2018;25:255-267 pubmed publisher
|
| Saraswat Ohri S, Mullins A, Hetman M, Whittemore S. Activating Transcription Factor-6α Deletion Modulates the Endoplasmic Reticulum Stress Response after Spinal Cord Injury but Does Not Affect Locomotor Recovery. J Neurotrauma. 2018;35:486-491 pubmed publisher
|
| Shelkovnikova T, Dimasi P, Kukharsky M, An H, Quintiero A, Schirmer C, et al. Chronically stressed or stress-preconditioned neurons fail to maintain stress granule assembly. Cell Death Dis. 2017;8:e2788 pubmed publisher
|
| Dunlop E, Johnson C, Wiltshire M, Errington R, Tee A. Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively induces death of mTORC1 hyperactive cells. Oncotarget. 2017;8:48711-48724 pubmed publisher
|
| Dalet A, Argüello R, Combes A, Spinelli L, Jaeger S, Fallet M, et al. Protein synthesis inhibition and GADD34 control IFN-β heterogeneous expression in response to dsRNA. EMBO J. 2017;36:761-782 pubmed publisher
|
| Sidoli M, Musner N, Silvestri N, Ungaro D, D Antonio M, Cavener D, et al. Ablation of Perk in Schwann Cells Improves Myelination in the S63del Charcot-Marie-Tooth 1B Mouse. J Neurosci. 2016;36:11350-11361 pubmed
|
| Young S, Shao Y, Bidwell J, Wek R. Nuclear Matrix Protein 4 Is a Novel Regulator of Ribosome Biogenesis and Controls the Unfolded Protein Response via Repression of Gadd34 Expression. J Biol Chem. 2016;291:13780-8 pubmed publisher
|
| Musner N, Sidoli M, Zambroni D, Del Carro U, Ungaro D, D Antonio M, et al. Perk Ablation Ameliorates Myelination in S63del-Charcot-Marie-Tooth 1B Neuropathy. ASN Neuro. 2016;8: pubmed publisher
|
| Park J, Park E, Jung C, Kang S, Kim B, Jung Y, et al. Oral proteasome inhibitor with strong preclinical efficacy in myeloma models. BMC Cancer. 2016;16:247 pubmed publisher
|
| de Gassart A, Bujisic B, Zaffalon L, Decosterd L, Di Micco A, Frera G, et al. An inhibitor of HIV-1 protease modulates constitutive eIF2α dephosphorylation to trigger a specific integrated stress response. Proc Natl Acad Sci U S A. 2016;113:E117-26 pubmed publisher
|
| Radford H, Moreno J, Verity N, Halliday M, Mallucci G. PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia. Acta Neuropathol. 2015;130:633-42 pubmed publisher
|
| Young S, Willy J, Wu C, Sachs M, Wek R. Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response. J Biol Chem. 2015;290:28257-71 pubmed publisher
|
| Loveless T, Topacio B, Vashisht A, Galaang S, Ulrich K, Young B, et al. DNA Damage Regulates Translation through β-TRCP Targeting of CReP. PLoS Genet. 2015;11:e1005292 pubmed publisher
|
| van t Wout E, van Schadewijk A, van Boxtel R, Dalton L, Clarke H, Tommassen J, et al. Virulence Factors of Pseudomonas aeruginosa Induce Both the Unfolded Protein and Integrated Stress Responses in Airway Epithelial Cells. PLoS Pathog. 2015;11:e1004946 pubmed publisher
|
| Das I, Krzyzosiak A, Schneider K, Wrabetz L, D Antonio M, Barry N, et al. Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit. Science. 2015;348:239-42 pubmed publisher
|
| Chambers J, Dalton L, Clarke H, Malzer E, Dominicus C, Patel V, et al. Actin dynamics tune the integrated stress response by regulating eukaryotic initiation factor 2α dephosphorylation. elife. 2015;4: pubmed publisher
|
| Wu H, Wei L, Fan F, Ji S, Zhang S, Geng J, et al. Integration of Hippo signalling and the unfolded protein response to restrain liver overgrowth and tumorigenesis. Nat Commun. 2015;6:6239 pubmed publisher
|