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product summary
company name :
Proteintech Group
product type :
antibody
product name :
BAD
catalog :
10435-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry
citations: 36
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:800; loading ...; fig 4c, 5d
Ding X, Hu H, Huang K, Wei R, Min J, Qi C, et al. Ubiquitination of NOTCH2 by DTX3 suppresses the proliferation and migration of human esophageal carcinoma. Cancer Sci. 2020;111:489-501 pubmed publisher
Su Q, Wang J, Liu F, Zhang Y. Blocking Parkin/PINK1-mediated mitophagy sensitizes hepatocellular carcinoma cells to sanguinarine-induced mitochondrial apoptosis. Toxicol In Vitro. 2020;66:104840 pubmed publisher
Su W, Zhao J, Fan T. Dose- and Time-Dependent Cytotoxicity of Carteolol in Corneal Endothelial Cells and the Underlying Mechanisms. Front Pharmacol. 2020;11:202 pubmed publisher
Lin H, HAN H, Wang Y, He D, Sun W, Feng L, et al. Shikonin and 4-hydroxytamoxifen synergistically inhibit the proliferation of breast cancer cells through activating apoptosis signaling pathway in vitro and in vivo. Chin Med. 2020;15:23 pubmed publisher
Liu Y, Fan D. The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K. Nutrients. 2020;12: pubmed publisher
Wu P, Shi X, Luo M, Inam U Llah -, Li K, Zhang M, et al. Taurine inhibits neuron apoptosis in hippocampus of diabetic rats and high glucose exposed HT-22 cells via the NGF-Akt/Bad pathway. Amino Acids. 2020;52:87-102 pubmed publisher
Lin Y, Yu M, Fan T. Insights into mechanisms of pranoprofen-induced apoptosis and necroptosis in human corneal stromal cells. Toxicol Lett. 2020;320:9-18 pubmed publisher
Xu B, Sui Y, Fan T. Gatifloxacin inducing apoptosis of stromal fibroblasts through cross-talk between caspase-dependent extrinsic and intrinsic pathways. Int J Ophthalmol. 2019;12:1524-1530 pubmed publisher
Li M, Hao S, Li C, Xiao H, Sun L, Yu Z, et al. Elevated SH3BP5 Correlates with Poor Outcome and Contributes to the Growth of Acute Myeloid Leukemia Cells. Biomolecules. 2019;9: pubmed publisher
Li K, Shi X, Luo M, Inam U Llah -, Wu P, Zhang M, et al. Taurine protects against myelin damage of sciatic nerve in diabetic peripheral neuropathy rats by controlling apoptosis of schwann cells via NGF/Akt/GSK3β pathway. Exp Cell Res. 2019;:111557 pubmed publisher
Khan M, Zhao P, Khan A, Raza F, Raza S, Sarfraz M, et al. Synergism of cisplatin-oleanolic acid co-loaded calcium carbonate nanoparticles on hepatocellular carcinoma cells for enhanced apoptosis and reduced hepatotoxicity. Int J Nanomedicine. 2019;14:3753-3771 pubmed publisher
Wu D, Li M, Gao Y, Tian W, Li J, Zhang Q, et al. Peptide V3 Inhibits the Growth of Human Hepatocellular Carcinoma by Inhibiting the Ras/Raf/MEK/ERK Signaling Pathway. J Cancer. 2019;10:1693-1706 pubmed publisher
Gao F, Liang Y, Zhou P, Cheng J, Ding K, Wang Y. Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin. Eur J Med Chem. 2019;178:177-194 pubmed publisher
Liu H, Zhao J, Fu R, Zhu C, Fan D. The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway. PLoS ONE. 2019;14:e0216759 pubmed publisher
Dong Q, Yang B, Han J, Zhang M, Liu W, Zhang X, et al. A novel hydrogen sulfide-releasing donor, HA-ADT, suppresses the growth of human breast cancer cells through inhibiting the PI3K/AKT/mTOR and Ras/Raf/MEK/ERK signaling pathways. Cancer Lett. 2019;: pubmed publisher
Qin F, Wang Y, Jiang X, Wang Y, Zhang N, Wen X, et al. Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma. J Enzyme Inhib Med Chem. 2019;34:909-926 pubmed publisher
Zhao G, Li K, Chen J, Li L. Protective Effect of Extract of Bletilla Striata on Isoflurane Induced Neuronal Injury By Altering PI3K/Akt Pathway. Transl Neurosci. 2018;9:183-189 pubmed publisher
Tang J, Wang Z, Liu J, Zhou C, Chen J. Downregulation of 5-hydroxytryptamine receptor 3A expression exerts an anticancer activity against cell growth in colorectal carcinoma cells in vitro. Oncol Lett. 2018;16:6100-6108 pubmed publisher
Liu Y, Fan D. Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model. Food Funct. 2018;9:5513-5527 pubmed publisher
Yu G, Liao J, Wu J, Ding J, Zhang L. The proliferation of colorectal cancer cells is suppressed by silencing of EIF3H. Biosci Biotechnol Biochem. 2018;82:1694-1701 pubmed publisher
Zhang G, Lu D, Duan S, Gao Y, Liu S, Hong Y, et al. Hydrogen Sulfide Alleviates Lipopolysaccharide-Induced Diaphragm Dysfunction in Rats by Reducing Apoptosis and Inflammation through ROS/MAPK and TLR4/NF-κB Signaling Pathways. Oxid Med Cell Longev. 2018;2018:9647809 pubmed publisher
Peng X, Yan B, Shen Y. MiR-1301-3p inhibits human breast cancer cell proliferation by regulating cell cycle progression and apoptosis through directly targeting ICT1. Breast Cancer. 2018;25:742-752 pubmed publisher
Xue S, He W, Zeng X, Tang Z, Feng S, Zhong Z, et al. Hypothermic machine perfusion attenuates ischemia/reperfusion injury against rat livers donated after cardiac death by activating the Keap1/Nrf2‑ARE signaling pathway. Mol Med Rep. 2018;18:815-826 pubmed publisher
Wu D, Gao Y, Li T, Wang D, Lu D, Liu S, et al. PEST-containing nuclear protein mediates the proliferation, migration, and invasion of human neuroblastoma cells through MAPK and PI3K/AKT/mTOR signaling pathways. BMC Cancer. 2018;18:499 pubmed publisher
Tsai T, Lai K, Su J, Wu Y, Sheu J. 7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway. Mar Drugs. 2018;16: pubmed publisher
Mehmood T, Maryam A, Tian X, Khan M, Ma T. Santamarine Inhibits NF-?B and STAT3 Activation and Induces Apoptosis in HepG2 Liver Cancer Cells via Oxidative Stress. J Cancer. 2017;8:3707-3717 pubmed publisher
Ning C, Liang M, Liu S, Wang G, Edwards H, Xia Y, et al. Targeting ERK enhances the cytotoxic effect of the novel PI3K and mTOR dual inhibitor VS-5584 in preclinical models of pancreatic cancer. Oncotarget. 2017;8:44295-44311 pubmed publisher
Chen M, Lv J, Ye J, Cui X, Qu F, Chen L, et al. Disruption of serine/threonine protein phosphatase 5 inhibits tumorigenesis of urinary bladder cancer cells. Int J Oncol. 2017;51:39-48 pubmed publisher
Mao X, Li P, Wang Y, Liang Z, Liu J, Li J, et al. CRB3 regulates contact inhibition by activating the Hippo pathway in mammary epithelial cells. Cell Death Dis. 2017;8:e2546 pubmed publisher
Li Y, Jiang Z, Xue D, Deng G, Li M, Liu X, et al. Mycoplasma ovipneumoniae induces sheep airway epithelial cell apoptosis through an ERK signalling-mediated mitochondria pathway. BMC Microbiol. 2016;16:222 pubmed
Chai R, Yu X, Tu S, Zheng B. Depletion of UBA protein 2-like protein inhibits growth and induces apoptosis of human colorectal carcinoma cells. Tumour Biol. 2016;37:13225-13235 pubmed
Zhang Z, Li C, Shang L, Zhang Y, Zou R, Zhan Y, et al. Sulforaphane induces apoptosis and inhibits invasion in U251MG glioblastoma cells. Springerplus. 2016;5:235 pubmed publisher
Xu Y, Wu D, Fan Y, Li P, DU H, Shi J, et al. Novel Recombinant Protein FlaA N/C Protects against Radiation Injury via NF-κB Signaling. Radiat Res. 2016;185:77-86 pubmed publisher
Xie H, Xu Z, Tang J, Du Y, Huang L, Yu P, et al. Effect of Huaier on the proliferation and apoptosis of human gastric cancer cells through modulation of the PI3K/AKT signaling pathway. Exp Ther Med. 2015;10:1212-1218 pubmed
Dai B, Wang W, Liu R, Wang H, Zhang Y. Novel taspine derivative 12k inhibits cell growth and induces apoptosis in lung cell carcinoma. Biomed Pharmacother. 2015;70:227-33 pubmed publisher
Lu Q, Lv M, Xu E, Shao F, Feng Y, Yang J, et al. Recombinant hirudin suppresses the viability, adhesion, migration and invasion of Hep-2 human laryngeal cancer cells. Oncol Rep. 2015;33:1358-64 pubmed publisher
product information
CatalogNo :
10435-1-AP
AntigenName :
BAD
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
BCL2-associated agonist of cell death
Immunogen :
Recombinant Protein
Species :
human, mouse, rat, sheep
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IHC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
BAD, BBC2, BBC6
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC001901
Category :
Apoptosis;Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;Disease Related;Membrane Proteins;Neurology;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
AppTiter :
IHC 1:200 ; WB 1:1500 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.