This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
P21
catalog :
10355-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry
citations: 206
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 5b
Li K, Zhao S, Long J, Su J, Wu L, Tao J, et al. A novel chalcone derivative has antitumor activity in melanoma by inducing DNA damage through the upregulation of ROS products. Cancer Cell Int. 2020;20:36 pubmed publisher
  • western blot; human; loading ...; fig 6d
Wei X, Yang X, Wang B, Yang Y, Fang Z, Yi C, et al. LncRNA MBNL1-AS1 represses cell proliferation and enhances cell apoptosis via targeting miR-135a-5p/PHLPP2/FOXO1 axis in bladder cancer. Cancer Med. 2020;9:724-736 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 3d
Wang Q, Jia S, Jiao Y, Xu L, Wang D, Chen X, et al. SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway. Int J Med Sci. 2019;16:1573-1582 pubmed publisher
  • western blot; human; loading ...; fig 2d
Liu H, Feng X, Yang B, Tong R, Lu Y, Chen D, et al. Dimethyl fumarate suppresses hepatocellular carcinoma progression via activating SOCS3/JAK1/STAT3 signaling pathway. Am J Transl Res. 2019;11:4713-4725 pubmed
  • western blot; human; 1:1000; loading ...; fig 6e
Sun B, Zhao X, Ming J, Liu X, Liu D, Jiang C. Stepwise detection and evaluation reveal miR-10b and miR-222 as a remarkable prognostic pair for glioblastoma. Oncogene. 2019;38:6142-6157 pubmed publisher
  • western blot; human; loading ...; fig 6d
Ye Z, Zeng Z, Shen Y, Yang Q, Chen D, Chen Z, et al. ODC1 promotes proliferation and mobility via the AKT/GSK3β/β-catenin pathway and modulation of acidotic microenvironment in human hepatocellular carcinoma. Onco Targets Ther. 2019;12:4081-4092 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5c
Lin X, Zhan J, Zhong J, Wang Y, Wang Y, Li S, et al. lncRNA-ES3/miR-34c-5p/BMF axis is involved in regulating high-glucose-induced calcification/senescence of VSMCs. Aging (Albany NY). 2019;11:523-535 pubmed publisher
  • western blot; human; fig 2
Dai Y, Wang L, Tang J, Cao P, Luo Z, Sun J, et al. Activation of anaphase-promoting complex by p53 induces a state of dormancy in cancer cells against chemotherapeutic stress. Oncotarget. 2016;7:25478-92 pubmed publisher
Zhu X, Chen T, Yang H, Lv K. Lactate induced up-regulation of KLHDC8A (Kelch domain-containing 8A) contributes to the proliferation, migration and apoptosis of human glioma cells. J Cell Mol Med. 2020;: pubmed publisher
Hu Z, Wang H, Fu Y, Ma K, Ma X, Wang J. Gentiopicroside Inhibits Cell Growth and Migration on Cervical Cancer via the Reciprocal MAPK/Akt Signaling Pathways. Nutr Cancer. 2020;:1-12 pubmed publisher
Zhang D, Fan R, Lei L, Lei L, Wang Y, Lv N, et al. Cell cycle exit during bortezomib-induced osteogenic differentiation of mesenchymal stem cells was mediated by Xbp1s-upregulated p21Cip1 and p27Kip1. J Cell Mol Med. 2020;: pubmed publisher
Yu M, Ren L, Liang F, Zhang Y, Jiang L, Ma W, et al. Effect of epiberberine from Coptis chinensis Franch on inhibition of tumor growth in MKN-45 xenograft mice. Phytomedicine. 2020;76:153216 pubmed publisher
Jin X, Ge L, Li D, Shao Z, Di G, Xu X, et al. LncRNA TROJAN promotes proliferation and resistance to CDK4/6 inhibitor via CDK2 transcriptional activation in ER+ breast cancer. Mol Cancer. 2020;19:87 pubmed publisher
Zhang Y, Luo L, Wang Y, Zhu N, Zhao T, Qin L. Total saponins from Lilium lancifolium: a promising alternative to inhibit the growth of gastric carcinoma cells. J Cancer. 2020;11:4261-4273 pubmed publisher
Pereira E, Burns J, Lee C, Marohl T, Calderon D, Wang L, et al. Sporadic activation of an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies. Sci Signal. 2020;13: pubmed publisher
Jia Y, Jin H, Gao L, Yang X, Wang F, Ding H, et al. A novel lncRNA PLK4 up-regulated by talazoparib represses hepatocellular carcinoma progression by promoting YAP-mediated cell senescence. J Cell Mol Med. 2020;24:5304-5316 pubmed publisher
Wang J, Li G, Ming S, Wang C, Shi L, Su B, et al. BRD4 inhibition exerts anti-viral activity through DNA damage-dependent innate immune responses. PLoS Pathog. 2020;16:e1008429 pubmed publisher
Zhang Y, Cui N, Zheng G. Ubiquitination of P53 by E3 ligase MKRN2 promotes melanoma cell proliferation. Oncol Lett. 2020;19:1975-1984 pubmed publisher
Wang N, Liu H, Liu G, Li M, He X, Yin C, et al. Yeast β-D-glucan exerts antitumour activity in liver cancer through impairing autophagy and lysosomal function, promoting reactive oxygen species production and apoptosis. Redox Biol. 2020;32:101495 pubmed publisher
Wu J, Su H, Yu Z, Xi S, Guo C, Hu Z, et al. Skp2 modulates proliferation, senescence and tumorigenesis of glioma. Cancer Cell Int. 2020;20:71 pubmed publisher
Zhao Q, Zhu H, Xie X, Mao Q, Liu Y, He X, et al. Novel HSP90-PI3K Dual Inhibitor Suppresses Melanoma Cell Proliferation by Interfering with HSP90-EGFR Interaction and Downstream Signaling Pathways. Int J Mol Sci. 2020;21: pubmed publisher
Lin Z, Qu S, Peng W, Yang P, Zhang R, Zhang P, et al. Up-Regulated CCDC34 Contributes to the Proliferation and Metastasis of Hepatocellular Carcinoma. Onco Targets Ther. 2020;13:51-60 pubmed publisher
Zhao H, Wang Y, Yang C, Zhou J, Wang L, Yi K, et al. EGFR-vIII downregulated H2AZK4/7AC though the PI3K/AKT-HDAC2 axis to regulate cell cycle progression. Clin Transl Med. 2020;9:10 pubmed publisher
Auclair M, Guénantin A, Fellahi S, Garcia M, Capeau J. HIV antiretroviral drugs, dolutegravir, maraviroc and ritonavir-boosted atazanavir use different pathways to affect inflammation, senescence and insulin sensitivity in human coronary endothelial cells. PLoS ONE. 2020;15:e0226924 pubmed publisher
Masre S, Rath N, Olson M, Greenhalgh D. Epidermal ROCK2-induces AKT1/GSK3β/β-catenin, NFκB and dermal tenascin-C; but enhanced differentiation and p53/p21 inhibit papilloma. Carcinogenesis. 2020;: pubmed publisher
Wang J, Li S, Wang J, Wu F, Chen Y, Zhang H, et al. Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function. Aging (Albany NY). 2020;12:650-671 pubmed publisher
Du X, Tu Y, Liu S, Zhao P, Bao Z, Li C, et al. LINC00511 contributes to glioblastoma tumorigenesis and epithelial-mesenchymal transition via LINC00511/miR-524-5p/YB1/ZEB1 positive feedback loop. J Cell Mol Med. 2020;24:1474-1487 pubmed publisher
Li F, Zhao F, Li M, Pan M, Shi F, Xu H, et al. Decreasing New York esophageal squamous cell carcinoma 1 expression inhibits multiple myeloma growth and osteolytic lesions. J Cell Physiol. 2020;235:2183-2194 pubmed publisher
Guo S, Jian L, Tao K, Chen C, Yu H, Liu S. Novel Breast-Specific Long Non-coding RNA LINC00993 Acts as a Tumor Suppressor in Triple-Negative Breast Cancer. Front Oncol. 2019;9:1325 pubmed publisher
Zhao J, Honda Y, Tanaka T, Hashimoto Y, Matsumoto N. Releasing Behavior of Lipopolysaccharide from Gelatin Modulates Inflammation, Cellular Senescence, and Bone Formation in Critical-Sized Bone Defects in Rat Calvaria. Materials (Basel). 2019;13: pubmed publisher
Wu Z, Chen D, Wang K, Cao C, Xu X. Long Non-coding RNA SNHG12 Functions as a Competing Endogenous RNA to Regulate MDM4 Expression by Sponging miR-129-5p in Clear Cell Renal Cell Carcinoma. Front Oncol. 2019;9:1260 pubmed publisher
Li Y, Li X, Cao M, Jiang Y, Yan J, Liu Z, et al. Seryl tRNA synthetase cooperates with POT1 to regulate telomere length and cellular senescence. Signal Transduct Target Ther. 2019;4:50 pubmed publisher
Li F, Su M, Zhao H, Xie W, Cao S, Xu Y, et al. HnRNP-F promotes cell proliferation by regulating TPX2 in bladder cancer. Am J Transl Res. 2019;11:7035-7048 pubmed
Li Y, Zu X, Hu X, Wang L, He W. Forkhead Box R2 Knockdown Decreases Chemoresistance to Cisplatin via MYC Pathway in Bladder Cancer. Med Sci Monit. 2019;25:8928-8939 pubmed publisher
Chen J, Sun X, Mao Q, Jiang X, Zhao X, Xu W, et al. Increased expression of hematological and neurological expressed 1 (HN1) is associated with a poor prognosis of hepatocellular carcinoma and its knockdown inhibits cell growth and migration partly by down-regulation of c-Met. Kaohsiung J Med Sci. 2019;: pubmed publisher
Wu J, Lu K, Zhu M, Xie X, Ding Y, Shao X, et al. miR-485 suppresses inflammation and proliferation of mesangial cells in an in vitro model of diabetic nephropathy by targeting NOX5. Biochem Biophys Res Commun. 2019;: pubmed publisher
Liu L, Wang F, Tong Y, Li L, Liu Y, Gao W. Pentamidine inhibits prostate cancer progression via selectively inducing mitochondrial DNA depletion and dysfunction. Cell Prolif. 2019;:e12718 pubmed publisher
Xue Y, Lian W, Zhi J, Yang W, Li Q, Guo X, et al. HDAC5-mediated deacetylation and nuclear localisation of SOX9 is critical for tamoxifen resistance in breast cancer. Br J Cancer. 2019;121:1039-1049 pubmed publisher
Zhao X, Zhang C, Wei X, Shi L, Dai S, Jia J, et al. CARLo-5 as an oncogenic gene in endometrial carcinoma. Environ Mol Mutagen. 2019;: pubmed publisher
Hu Y, Ma S, Zhang X, Zhang Z, Zhu H, Ji Y, et al. Hypermethylation Of ADHFE1 Promotes The Proliferation Of Colorectal Cancer Cell Via Modulating Cell Cycle Progression. Onco Targets Ther. 2019;12:8105-8115 pubmed publisher
Li S, Han J, Guo G, Sun Y, Zhang T, Zhao M, et al. Voltage-gated sodium channels β3 subunit promotes tumorigenesis in hepatocellular carcinoma by facilitating p53 degradation. FEBS Lett. 2019;: pubmed publisher
Liu L, Zhu J, Yu X, Zhu H, Shi X, Bilegsaikhan E, et al. UBE2T promotes proliferation via G2/M checkpoint in hepatocellular carcinoma. Cancer Manag Res. 2019;11:8359-8370 pubmed publisher
Tian S, Feng J, Cao Y, Shen S, Cai Y, Yang D, et al. Glycine cleavage system determines the fate of pluripotent stem cells via the regulation of senescence and epigenetic modifications. Life Sci Alliance. 2019;2: pubmed publisher
Gao X, Zhang Y, Zhang R, Zhao Z, Zhang H, Wu J, et al. Cyclin-dependent kinase 1 disruption inhibits angiogenesis by inducing cell cycle arrest and apoptosis. Exp Ther Med. 2019;18:3062-3070 pubmed publisher
Pan C, Lang H, Zhang T, Wang R, Lin X, Shi P, et al. Conditioned medium derived from human amniotic stem cells delays H2O2‑induced premature senescence in human dermal fibroblasts. Int J Mol Med. 2019;44:1629-1640 pubmed publisher
Zhang Z, Li X, Han Y, Ji T, Huang X, Gao Q, et al. RAD54B potentiates tumor growth and predicts poor prognosis of patients with luminal A breast cancer. Biomed Pharmacother. 2019;118:109341 pubmed publisher
Wei C, Zhang R, Cai Q, Gao X, Tong F, Dong J, et al. MicroRNA-330-3p promotes brain metastasis and epithelial-mesenchymal transition via GRIA3 in non-small cell lung cancer. Aging (Albany NY). 2019;11:6734-6761 pubmed publisher
He J, Hong B, Bian M, Jin H, Chen J, Shao J, et al. Docosahexaenoic acid inhibits hepatic stellate cell activation to attenuate liver fibrosis in a PPARγ-dependent manner. Int Immunopharmacol. 2019;75:105816 pubmed publisher
Sun S, Hu Z, Huang S, Ye X, Wang J, Chang J, et al. REG4 is an indicator for KRAS mutant lung adenocarcinoma with TTF-1 low expression. J Cancer Res Clin Oncol. 2019;145:2273-2283 pubmed publisher
Guo J, Wang Q, Zhang Y, Sun W, Zhang S, Li Y, et al. Functional daidzein enhances the anticancer effect of topotecan and reverses BCRP-mediated drug resistance in breast cancer. Pharmacol Res. 2019;147:104387 pubmed publisher
Que Z, Zhou Z, Luo B, Dong C, Jiang Y, Li H, et al. Jingfukang induces anti-cancer activity through oxidative stress-mediated DNA damage in circulating human lung cancer cells. BMC Complement Altern Med. 2019;19:204 pubmed publisher
Fan X, Wang Y, Song J, Wu H, Yang M, Lu L, et al. MDM2 inhibitor RG7388 potently inhibits tumors by activating p53 pathway in nasopharyngeal carcinoma. Cancer Biol Ther. 2019;:1-9 pubmed publisher
Liu Y, Fan D. Ginsenoside Rg5 induces G2/M phase arrest, apoptosis and autophagy via regulating ROS-mediated MAPK pathways against human gastric cancer. Biochem Pharmacol. 2019;168:285-304 pubmed publisher
Li S, Yao M, Niu C, Liu D, Tang Z, Gu C, et al. Inhibition of MCF-7 breast cancer cell proliferation by a synthetic peptide derived from the C-terminal sequence of Orai channel. Biochem Biophys Res Commun. 2019;516:1066-1072 pubmed publisher
Yang B, Wu A, Hu Y, Tao C, Wang J, Lu Y, et al. Mucin 17 inhibits the progression of human gastric cancer by limiting inflammatory responses through a MYH9-p53-RhoA regulatory feedback loop. J Exp Clin Cancer Res. 2019;38:283 pubmed publisher
Gao F, Liang Y, Zhou P, Cheng J, Ding K, Wang Y. Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin. Eur J Med Chem. 2019;178:177-194 pubmed publisher
Zhou W, Ma L, Yang J, Qiao H, Li L, Guo Q, et al. Potent and specific MTH1 inhibitors targeting gastric cancer. Cell Death Dis. 2019;10:434 pubmed publisher
Wang S, Wang W, Liu J, Song Y, Li P, Sun X, et al. Methionine restriction delays senescence and suppresses the senescence-associated secretory phenotype in the kidney through endogenous hydrogen sulfide. Cell Cycle. 2019;18:1573-1587 pubmed publisher
Luo Y, Xie C, Brocker C, Fan J, Wu X, Feng L, et al. Intestinal PPARα Protects Against Colon Carcinogenesis via Regulation of Methyltransferases DNMT1 and PRMT6. Gastroenterology. 2019;: pubmed publisher
Zheng M, Tian C, Fan T, Xu B. Fibronectin regulates the self-renewal of rabbit limbal epithelial stem cells by stimulating the Wnt11/Fzd7/ROCK non-canonical Wnt pathway. Exp Eye Res. 2019;185:107681 pubmed publisher
Wang S, Wang H, Sun B, Li D, Wu J, Li J, et al. Acetyl-11-keto-β-boswellic acid triggers premature senescence via induction of DNA damage accompanied by impairment of DNA repair genes in hepatocellular carcinoma cells in vitro and in vivo. Fundam Clin Pharmacol. 2019;: pubmed publisher
Yu H, Sun L, Cui J, Li Y, Yan Y, Wei X, et al. Three kinds of corneal host cells contribute differently to corneal neovascularization. EBioMedicine. 2019;: pubmed publisher
Liu H, Zhao J, Fu R, Zhu C, Fan D. The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway. PLoS ONE. 2019;14:e0216759 pubmed publisher
Yan Y, Yu H, Sun L, Liu H, Wang C, Wei X, et al. Laminin α4 overexpression in the anterior lens capsule may contribute to the senescence of human lens epithelial cells in age-related cataract. Aging (Albany NY). 2019;11:2699-2723 pubmed publisher
Sui Y, Wu T, Li F, Wang F, Cai Y, Jin J. YY1/BCCIP Coordinately Regulates P53-Responsive Element (p53RE)-Mediated Transactivation of p21Waf1/Cip1. Int J Mol Sci. 2019;20: pubmed publisher
Li N, Piao J, Wang X, Kim K, Bae J, Ren X, et al. Paip1 Indicated Poor Prognosis in Cervical Cancer and Promoted Cervical Carcinogenesis. Cancer Res Treat. 2019;: pubmed publisher
Sun J, Zhang H, Tao D, Xie F, Liu F, Gu C, et al. CircCDYL inhibits the expression of C-MYC to suppress cell growth and migration in bladder cancer. Artif Cells Nanomed Biotechnol. 2019;47:1349-1356 pubmed publisher
Qin F, Wang Y, Jiang X, Wang Y, Zhang N, Wen X, et al. Design, synthesis and molecular mechanisms of novel dual inhibitors of heat shock protein 90/phosphoinositide 3-kinase alpha (Hsp90/PI3Kα) against cutaneous melanoma. J Enzyme Inhib Med Chem. 2019;34:909-926 pubmed publisher
Li X, Wu J, Liu S, Zhang K, Miao X, Li J, et al. miR-384-5p Targets Gli2 and Negatively Regulates Age-Related Osteogenic Differentiation of Rat Bone Marrow Mesenchymal Stem Cells. Stem Cells Dev. 2019;28:791-798 pubmed publisher
Shen Z, Liao X, Shao Z, Feng M, Yuan J, Wang S, et al. Short-term stimulation with histone deacetylase inhibitor trichostatin a induces epithelial-mesenchymal transition in nasopharyngeal carcinoma cells without increasing cell invasion ability. BMC Cancer. 2019;19:262 pubmed publisher
Qin H, Li Y, Zhang H, Wang F, He H, Bai X, et al. Prognostic implications and oncogenic roles of MYBL2 protein expression in esophageal squamous-cell carcinoma. Onco Targets Ther. 2019;12:1917-1927 pubmed publisher
Zhao Z, Li L, Du P, Ma L, Zhang W, Zheng L, et al. Transcriptional Downregulation of miR-4306 serves as a New Therapeutic Target for Triple Negative Breast Cancer. Theranostics. 2019;9:1401-1416 pubmed publisher
Bie Y, Gu P, Chen Y, Zhou X, Tian Y, Yang Q, et al. TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway. J Transl Med. 2019;17:72 pubmed publisher
Wang D, Li W, Zhao R, Chen L, Liu N, Tian Y, et al. Stabilized Peptide HDAC Inhibitors Derived from HDAC1 Substrate H3K56 for the Treatment of Cancer Stem-Like Cells In Vivo. Cancer Res. 2019;79:1769-1783 pubmed publisher
Sui A, Xu Y, Pan B, Guo T, Wu J, Shen Y, et al. Histone demethylase KDM6B regulates 1,25-dihydroxyvitamin D3-induced senescence in glioma cells. J Cell Physiol. 2019;: pubmed publisher
Sun X, Xie Y, Sun X, Yao Y, Li H, Li Z, et al. The selective HDAC6 inhibitor Nexturastat A induces apoptosis, overcomes drug resistance and inhibits tumor growth in multiple myeloma. Biosci Rep. 2019;: pubmed publisher
Peng W, Tong C, Li L, Huang C, Ran Y, Chen X, et al. Trophoblastic proliferation and invasion regulated by ACTN4 is impaired in early onset preeclampsia. FASEB J. 2019;33:6327-6338 pubmed publisher
Wudu M, Ren H, Hui L, Jiang J, Zhang S, Xu Y, et al. DRAM2 acts as an oncogene in non-small cell lung cancer and suppresses the expression of p53. J Exp Clin Cancer Res. 2019;38:72 pubmed publisher
Gu X, Wang Z, Gao J, Han D, Zhang L, Chen P, et al. SIRT1 suppresses p53-dependent apoptosis by modulation of p21 in osteoblast-like MC3T3-E1 cells exposed to fluoride. Toxicol In Vitro. 2019;57:28-38 pubmed publisher
Chen L, He P, Yang J, Yang Y, Wang K, Amend B, et al. NLRP3/IL1β inflammasome associated with the aging bladder triggers bladder dysfunction in female rats. Mol Med Rep. 2019;19:2960-2968 pubmed publisher
Han Y, Wu P, Wang Z, Zhang Z, Sun S, Liu J, et al. Ubiquinol-cytochrome C reductase core protein II promotes tumorigenesis by facilitating p53 degradation. EBioMedicine. 2019;40:92-105 pubmed publisher
Zhou Y, Niu W, Luo Y, Li H, Xie Y, Wang H, et al. The p53/LDHA axis negatively regulates aerobic glycolysis and tumor progression in breast cancer expressing wild-type p53. Cancer Sci. 2019;: pubmed publisher
Wei X, Luo D, Yan Y, Yu H, Sun L, Wang C, et al. Kojic acid inhibits senescence of human corneal endothelial cells via NF-κB and p21 signaling pathways. Exp Eye Res. 2019;180:174-183 pubmed publisher
Liang X, Ding Y, Lin F, Zhang Y, Zhou X, Meng Q, et al. Overexpression of ERBB4 rejuvenates aged mesenchymal stem cells and enhances angiogenesis via PI3K/AKT and MAPK/ERK pathways. FASEB J. 2019;33:4559-4570 pubmed publisher
Guo J, Tang Q, Wang Q, Sun W, Pu Z, Wang J, et al. Pifithrin-α enhancing anticancer effect of topotecan on p53-expressing cancer cells. Eur J Pharm Sci. 2019;128:61-72 pubmed publisher
Cui D, Zhao Y, Xu J. Activation of CXCL5-CXCR2 axis promotes proliferation and accelerates G1 to S phase transition of papillary thyroid carcinoma cells and activates JNK and p38 pathways. Cancer Biol Ther. 2019;20:608-616 pubmed publisher
Pan J, Zhou H, Zhu S, Huang J, Zhao X, Ding H, et al. Nicotinamide phosphoribosyl transferase regulates cell growth via the Sirt1/P53 signaling pathway and is a prognosis marker in colorectal cancer. J Cell Physiol. 2019;234:4385-4395 pubmed publisher
Chen Y, Tzeng D, Huang Y, Lin C, Lo U, Wu C, et al. Antrocin Sensitizes Prostate Cancer Cells to Radiotherapy through Inhibiting PI3K/AKT and MAPK Signaling Pathways. Cancers (Basel). 2018;11: pubmed publisher
Wang L, Han X, Qu G, Su L, Zhao B, Miao J. A pH probe inhibits senescence in mesenchymal stem cells. Stem Cell Res Ther. 2018;9:343 pubmed publisher
Fan Y, Mao Y, Cao S, Xia G, Zhang Q, Zhang H, et al. S5, a Withanolide Isolated from Physalis Pubescens L., Induces G2/M Cell Cycle Arrest via the EGFR/P38 Pathway in Human Melanoma A375 Cells. Molecules. 2018;23: pubmed publisher
Chen M, Zhang H, Zhang G, Zhong A, Ma Q, Kai J, et al. Targeting TPX2 suppresses proliferation and promotes apoptosis via repression of the PI3k/AKT/P21 signaling pathway and activation of p53 pathway in breast cancer. Biochem Biophys Res Commun. 2018;507:74-82 pubmed publisher
Liu L, Sun Y, Zhao Y, Wang Q, Guo H, Guo R, et al. Urea transport B gene induces melanoma B16 cell death via activation of p53 and mitochondrial apoptosis. Cancer Sci. 2018;109:3762-3773 pubmed publisher
Xie F, Li Y, Wang M, Huang C, Tao D, Zheng F, et al. Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis. Mol Cancer. 2018;17:144 pubmed publisher
Wen W, Chen J, Ding L, Luo X, Zheng X, Dai Q, et al. Astragaloside exerts anti-photoaging effects in UVB-induced premature senescence of rat dermal fibroblasts through enhanced autophagy. Arch Biochem Biophys. 2018;657:31-40 pubmed publisher
Yu M, Wang H, Liu J, Qin H, Liu S, Yan Q. The sialyltransferase ST3Gal3 facilitates the receptivity of the uterine endometrium in vitro and in vivo. FEBS Lett. 2018;592:3696-3707 pubmed publisher
Chen X, Liu C, Zhao R, Zhao P, Wu J, Zhou N, et al. Synergetic and Antagonistic Molecular Effects Mediated by the Feedback Loop of p53 and JNK between Saikosaponin D and SP600125 on Lung Cancer A549 Cells. Mol Pharm. 2018;15:4974-4984 pubmed publisher
Wang Z, Wang Y, Wang S, Meng X, Song F, Huo W, et al. Coxsackievirus A6 Induces Cell Cycle Arrest in G0/G1 Phase for Viral Production. Front Cell Infect Microbiol. 2018;8:279 pubmed publisher
Li Z, Qiu R, Qiu X, Tian T. SNHG6 Promotes Tumor Growth via Repression of P21 in Colorectal Cancer. Cell Physiol Biochem. 2018;49:463-478 pubmed publisher
Napoli E, Song G, Panoutsopoulos A, Riyadh M, Kaushik G, Halmai J, et al. Beyond autophagy: a novel role for autism-linked Wdfy3 in brain mitophagy. Sci Rep. 2018;8:11348 pubmed publisher
Luo W, Wang Y, Yang H, Dai C, Hong H, Li J, et al. Heme oxygenase-1 ameliorates oxidative stress-induced endothelial senescence via regulating endothelial nitric oxide synthase activation and coupling. Aging (Albany NY). 2018;10:1722-1744 pubmed publisher
Badi I, Mancinelli L, Polizzotto A, Ferri D, Zeni F, Burba I, et al. miR-34a Promotes Vascular Smooth Muscle Cell Calcification by Downregulating SIRT1 (Sirtuin 1) and Axl (AXL Receptor Tyrosine Kinase). Arterioscler Thromb Vasc Biol. 2018;38:2079-2090 pubmed publisher
Huang B, Lv D, Wang C, Shu F, Gong Z, Xie T, et al. Suppressed epithelial-mesenchymal transition and cancer stem cell properties mediate the anti-cancer effects of ethyl pyruvate via regulation of the AKT/nuclear factor-?B pathway in prostate cancer cells. Oncol Lett. 2018;16:2271-2278 pubmed publisher
Yang H, Hong H, Luo W, Dai C, Chen X, Wang L, et al. mTORC2 facilitates endothelial cell senescence by suppressing Nrf2 expression via the Akt/GSK-3β/C/EBPα signaling pathway. Acta Pharmacol Sin. 2018;39:1837-1846 pubmed publisher
Chen S, Lin T, Tseng Y, Tu C, Lui T, Huang S, et al. Targeting inhibitors of apoptosis proteins suppresses medulloblastoma cell proliferation via G2/M phase arrest and attenuated neddylation of p21. Cancer Med. 2018;7:3988-4003 pubmed publisher
Liu L, Sun X, Xie Y, Zhuang Y, Yao R, Xu K. Anticancer effect of histone deacetylase inhibitor scriptaid as a single agent for hepatocellular carcinoma. Biosci Rep. 2018;38: pubmed publisher
Liu X, Zhao Y, Zhang W, Gao Y, Huo M, Liu M, et al. Inhibition of survivin enhances radiosensitivity of esophageal cancer cells by switching radiation-induced senescence to apoptosis. Onco Targets Ther. 2018;11:3087-3100 pubmed publisher
Xue X, Wang X, Zhao Y, Hu R, Qin L. Exosomal miR-93 promotes proliferation and invasion in hepatocellular carcinoma by directly inhibiting TIMP2/TP53INP1/CDKN1A. Biochem Biophys Res Commun. 2018;502:515-521 pubmed publisher
Ling Z, Guan H, You Z, Wang C, Hu L, Zhang L, et al. Aloperine executes antitumor effects through the induction of apoptosis and cell cycle arrest in prostate cancer in vitro and in vivo. Onco Targets Ther. 2018;11:2735-2743 pubmed publisher
Wu F, Li S, Zhang N, Huang W, Li X, Wang M, et al. Hispidulin alleviates high-glucose-induced podocyte injury by regulating protective autophagy. Biomed Pharmacother. 2018;104:307-314 pubmed publisher
Jiang B, Zhao W, Shi M, Zhang J, Chen A, Ma H, et al. IDH1 Arg-132 mutant promotes tumor formation through down-regulating p53. J Biol Chem. 2018;293:9747-9758 pubmed publisher
Liu L, Sun X, Xie Y, Zhuang Y, Yao R, Xu K. Anti-Proliferative Activity of HPOB against Multiple Myeloma Cells via p21 Transcriptional Activation. Molecules. 2018;23: pubmed publisher
Wang J, Chen J, Jiang Y, Shi Y, Zhu J, Xie C, et al. Wnt/?-catenin modulates chronic tobacco smoke exposure-induced acquisition of pulmonary cancer stem cell properties and diallyl trisulfide intervention. Toxicol Lett. 2018;291:70-76 pubmed publisher
Uesato T, Ogihara T, Hara A, Iida H, Miyatsuka T, Fujitani Y, et al. Enhanced Expression of the Key Mitosis Regulator Cyclin B1 Is Mediated by PDZ-Binding Kinase in Islets of Pregnant Mice. J Endocr Soc. 2018;2:207-219 pubmed publisher
Jia W, Jiang X, Liu W, Wang L, Zhu B, Zhu H, et al. Effects of three-dimensional collagen scaffolds on the expression profiles and biological functions of glioma cells. Int J Oncol. 2018;52:1787-1800 pubmed publisher
Wang H, Zhong Q, Yang T, Qi Y, Fu M, Yang X, et al. Comparative characterization of SHED and DPSCs during extended cultivation in vitro. Mol Med Rep. 2018;17:6551-6559 pubmed publisher
Zhang T, Wang P, Liu Y, Zhou J, Shi Z, Cheng K, et al. Overexpression of FOXQ1 enhances anti-senescence and migration effects of human umbilical cord mesenchymal stem cells in vitro and in vivo. Cell Tissue Res. 2018;373:379-393 pubmed publisher
Ye P, Ke X, Zang X, Sun H, Dong Z, Lin J, et al. Up-regulated MiR-27-3p promotes the G1-S phase transition by targeting inhibitor of growth family member 5 in osteosarcoma. Biomed Pharmacother. 2018;101:219-227 pubmed publisher
Bao Y, Zhang S, Guo Y, Wei X, Zhang Y, Yang Y, et al. Stromal expression of JNK1 and VDR is associated with the prognosis of esophageal squamous cell carcinoma. Clin Transl Oncol. 2018;20:1185-1195 pubmed publisher
Zhang J, Yuan J, Wang Q, Shao L, Liu S, Firestone R, et al. Experimental evidence of good efficacy and reduced toxicity with peptide-doxorubicin to treat gastric cancer. Oncotarget. 2018;9:1957-1968 pubmed publisher
Shen H, Zhan M, Zhang Y, Huang S, Xu S, Huang X, et al. PLZF inhibits proliferation and metastasis of gallbladder cancer by regulating IFIT2. Cell Death Dis. 2018;9:71 pubmed publisher
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product information
CatalogNo :
10355-1-AP
AntigenName :
P21
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
cyclin-dependent kinase inhibitor 1A (p21, Cip1)
Immunogen :
Recombinant Protein
Species :
artemia sinica, human, mouse, rat, swine
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, FC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
CAP20, CDK interacting protein 1, CDKN1, CDKN1A, CIP1, MDA 6, MDA6, P21, p21CIP1, PIC1, SDI1, WAF1
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC000275
Category :
Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;Disease Related;Metabolism;Oncogene(s) and Tumor Suppressor(s);Senescence;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:400 ; IP 1:1000 ; WB 1:800 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.