This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
SMAD4
catalog :
10231-1-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation
citations: 20
Reference
Li Y, Yang J, Zhang X, Liu H, Guo J. KDM6A suppresses hepatocellular carcinoma cell proliferation by negatively regulating the TGF-β/SMAD signaling pathway. Exp Ther Med. 2020;20:2774-2782 pubmed publisher
Wu N, Wu Z, Sun J, Yan M, Wang B, Du X, et al. Small airway remodeling in diabetic and smoking chronic obstructive pulmonary disease patients. Aging (Albany NY). 2020;12:7927-7944 pubmed publisher
Dong H, Diao H, Zhao Y, Xu H, Pei S, Gao J, et al. Overexpression of matrix metalloproteinase-9 in breast cancer cell lines remarkably increases the cell malignancy largely via activation of transforming growth factor beta/SMAD signalling. Cell Prolif. 2019;:e12633 pubmed publisher
Xue K, Zhang J, Li C, Li J, Wang C, Zhang Q, et al. The role and mechanism of transforming growth factor beta 3 in human myocardial infarction-induced myocardial fibrosis. J Cell Mol Med. 2019;23:4229-4243 pubmed publisher
Hu B, Mao Z, Du Q, Jiang X, Wang Z, Xiao Z, et al. miR-93-5p targets Smad7 to regulate the transforming growth factor-β1/Smad3 pathway and mediate fibrosis in drug-resistant prolactinoma. Brain Res Bull. 2019;149:21-31 pubmed publisher
Li X, Sui X, Yang Q, Li Y, Li N, Shi X, et al. Oviductus Ranae protein hydrolyzate prevents menopausal osteoporosis by regulating TGFβ/BMP2 signaling. Arch Gynecol Obstet. 2019;299:873-882 pubmed publisher
Liu K, Zhang X, Wei W, Liu X, Tian Y, Han H, et al. Myostatin/SMAD4 signaling-mediated regulation of miR-124-3p represses glucocorticoid receptor expression and inhibits adipocyte differentiation. Am J Physiol Endocrinol Metab. 2019;316:E635-E645 pubmed publisher
Kinterova V, Kanka J, Petruskova V, Toralova T. Inhibition of Skp1-Cullin-F-box complexes during bovine oocyte maturation and preimplantation development leads to delayed development of embryos†. Biol Reprod. 2019;100:896-906 pubmed publisher
Zhao X, An X, Zhu X, Jiang Y, Zhai Y, Zhang S, et al. Inhibiting transforming growth factor-β signaling regulates in vitro maintenance and differentiation of bovine bone marrow mesenchymal stem cells. J Exp Zool B Mol Dev Evol. 2018;330:406-416 pubmed publisher
Xu Y, Wang X, Huang Y, Ma Y, Jin X, Wang H, et al. Inhibition of lysyl oxidase expression by dextran sulfate affects invasion and migration of gastric cancer cells. Int J Mol Med. 2018;42:2737-2749 pubmed publisher
Xu Y, Luo X, Fang Z, Zheng X, Zeng Y, Zhu C, et al. Transcription coactivator Cited1 acts as an inducer of trophoblast-like state from mouse embryonic stem cells through the activation of BMP signaling. Cell Death Dis. 2018;9:924 pubmed publisher
Hu B, Mao Z, Jiang X, He D, Wang Z, Wang X, et al. Role of TGF-β1/Smad3-mediated fibrosis in drug resistance mechanism of prolactinoma. Brain Res. 2018;1698:204-212 pubmed publisher
Li W, Zhu D, Qin S. SIRT7 suppresses the epithelial-to-mesenchymal transition in oral squamous cell carcinoma metastasis by promoting SMAD4 deacetylation. J Exp Clin Cancer Res. 2018;37:148 pubmed publisher
Deng W, Gao M, Lei X, Lv J, Zhao H, He K, et al. Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients. Stem Cell Reports. 2018;10:1267-1281 pubmed publisher
Li J, Zou K, Yu L, Zhao W, Lu Y, Mao J, et al. MicroRNA-140 Inhibits the Epithelial-Mesenchymal Transition and Metastasis in Colorectal Cancer. Mol Ther Nucleic Acids. 2018;10:426-437 pubmed publisher
Chiou J, Su C, Jan Y, Yang C, Huang M, Yu Y, et al. Decrease of FSTL1-BMP4-Smad signaling predicts poor prognosis in lung adenocarcinoma but not in squamous cell carcinoma. Sci Rep. 2017;7:9830 pubmed publisher
Zhuang J, Shen L, Yang L, Huang X, Lu Q, Cui Y, et al. TGF?1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer. Theranostics. 2017;7:3053-3067 pubmed publisher
Lei K, Liang X, Gao Y, Xu B, Xu Y, Li Y, et al. Lnc-ATB contributes to gastric cancer growth through a MiR-141-3p/TGF?2 feedback loop. Biochem Biophys Res Commun. 2017;484:514-521 pubmed publisher
Wu T, Chen X, Peng R, Liu H, Yin P, Peng H, et al. Let?7a suppresses cell proliferation via the TGF??/SMAD signaling pathway in cervical cancer. Oncol Rep. 2016;36:3275-3282 pubmed publisher
Chen M, Zhang J, Wang J, Gao L, Chen X, Xiao J. Anti-fibrotic effects of neferine on carbon tetrachloride-induced hepatic fibrosis in mice. Am J Chin Med. 2015;43:231-40 pubmed publisher
product information
CatalogNo :
10231-1-AP
AntigenName :
SMAD4
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
SMAD family member 4
Immunogen :
Recombinant Protein
Species :
bovine, goat, human, mouse, rat
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IP, IHC, IF, CoIP, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
DPC4, hSMAD4, JIP, MAD homolog 4, MADH4, Mothers against DPP homolog 4, SMAD 4, SMAD family member 4, SMAD4
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC002379
Category :
Binding Proteins;Cell Cycle;Cytoskeleton/Scaffold Proteins;Development;Disease Related;Metabolism;Oncogene(s) and Tumor Suppressor(s);Signal transduction;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
AppTiter :
IHC 1:50 ; IP 1:600 ; WB 1:600 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.