This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Proteintech Group
product type :
antibody
product name :
ATG5
catalog :
10181-2-AP
quantity :
150UL
price :
299 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry
citations: 64
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 5b
Ni Z, Kuang L, Chen H, Xie Y, Zhang B, Ouyang J, et al. The exosome-like vesicles from osteoarthritic chondrocyte enhanced mature IL-1β production of macrophages and aggravated synovitis in osteoarthritis. Cell Death Dis. 2019;10:522 pubmed publisher
  • western blot; human; fig 10
Wang C, Ma Y, Hu Q, Xie T, Wu J, Zeng F, et al. Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors. BMC Cancer. 2016;16:545 pubmed publisher
Zou Y, Xu J, Wang X, Zhu Y, Wu Q, Wang J. Lactobacillus johnsonii L531 Ameliorates Escherichia coli-Induced Cell Damage via Inhibiting NLRP3 Inflammasome Activity and Promoting ATG5/ATG16L1-Mediated Autophagy in Porcine Mammary Epithelial Cells. Vet Sci. 2020;7: pubmed publisher
Yang Z, Chen Y, Wei X, Wu D, Min Z, Quan Y. Upregulated NTF4 in colorectal cancer promotes tumor development via regulating autophagy. Int J Oncol. 2020;56:1442-1454 pubmed publisher
Feng X, Zhang H, Meng L, Song H, Zhou Q, Qu C, et al. Hypoxia-induced acetylation of PAK1 enhances autophagy and promotes brain tumorigenesis via phosphorylating ATG5. Autophagy. 2020;:1-20 pubmed publisher
Wang X, Chi J, Huang D, Ding L, Zhao X, Jiang L, et al. α-synuclein promotes progression of Parkinson's disease by upregulating autophagy signaling pathway to activate NLRP3 inflammasome. Exp Ther Med. 2020;19:931-938 pubmed publisher
Liu Y, Fan D. The Preparation of Ginsenoside Rg5, Its Antitumor Activity against Breast Cancer Cells and Its Targeting of PI3K. Nutrients. 2020;12: pubmed publisher
Xia B, Yu J, He T, Liu X, Su J, Wang M, et al. Lactobacillus johnsonii L531 ameliorates enteritis via elimination of damaged mitochondria and suppression of SQSTM1-dependent mitophagy in a Salmonella infantis model of piglet diarrhea. FASEB J. 2020;34:2821-2839 pubmed publisher
Liu J, Zhu Z, Liu Y, Wei L, Li B, Mao F, et al. MDM2 inhibition-mediated autophagy contributes to the pro-apoptotic effect of berberine in p53-null leukemic cells. Life Sci. 2020;242:117228 pubmed publisher
Ying C, Ying L, Yanxia L, Le W, Lili C. High mobility group box 1 antibody represses autophagy and alleviates hippocampus damage in pilocarpine-induced mouse epilepsy model. Acta Histochem. 2020;122:151485 pubmed publisher
Li Y, Wu Y, Jiang K, Han W, Zhang J, Xie L, et al. Mangiferin Prevents TBHP-Induced Apoptosis and ECM Degradation in Mouse Osteoarthritic Chondrocytes via Restoring Autophagy and Ameliorates Murine Osteoarthritis. Oxid Med Cell Longev. 2019;2019:8783197 pubmed publisher
Inamura A, Muraoka Hirayama S, Sakurai K. Loss of Mitochondrial DNA by Gemcitabine Triggers Mitophagy and Cell Death. Biol Pharm Bull. 2019;42:1977-1987 pubmed publisher
Cheng F, Lee Y, Hsu Y, Chiu I, Chiu Y, Lin Y, et al. Promising therapeutic effect of thapsigargin nanoparticles on chronic kidney disease through the activation of Nrf2 and FoxO1. Aging (Albany NY). 2019;11:9875-9892 pubmed publisher
Wang D, Guo H, Yang H, Wang D, Gao P, Wei W. Pterostilbene, An Active Constituent of Blueberries, Suppresses Proliferation Potential of Human Cholangiocarcinoma via Enhancing the Autophagic Flux. Front Pharmacol. 2019;10:1238 pubmed publisher
Ma Z, Zhang J, Xu X, Qu Y, Dong H, Dang J, et al. LncRNA expression profile during autophagy and Malat1 function in macrophages. PLoS ONE. 2019;14:e0221104 pubmed publisher
Liu Y, Fan D. Ginsenoside Rg5 induces G2/M phase arrest, apoptosis and autophagy via regulating ROS-mediated MAPK pathways against human gastric cancer. Biochem Pharmacol. 2019;168:285-304 pubmed publisher
Zhou G, Tang S, Yang L, Niu Q, Chen J, Xia T, et al. Effects of long-term fluoride exposure on cognitive ability and the underlying mechanisms: Role of autophagy and its association with apoptosis. Toxicol Appl Pharmacol. 2019;:114608 pubmed publisher
Cheng X, Tan S, Duan F, Yuan Q, Li Q, Deng G. Icariin induces apoptosis by suppressing autophagy in tamoxifen-resistant breast cancer cell line MCF-7/TAM. Breast Cancer. 2019;: pubmed publisher
Liu H, Zhao J, Fu R, Zhu C, Fan D. The ginsenoside Rk3 exerts anti-esophageal cancer activity in vitro and in vivo by mediating apoptosis and autophagy through regulation of the PI3K/Akt/mTOR pathway. PLoS ONE. 2019;14:e0216759 pubmed publisher
Li R, Du J, Yao G, Yao Y, Zhang J. Autophagy: a new mechanism for regulating VEGF and PEDF expression in retinal pigment epithelium cells. Int J Ophthalmol. 2019;12:557-562 pubmed publisher
Li R, Du J, Yao Y, Yao G, Wang X. Adiponectin inhibits high glucose-induced angiogenesis via inhibiting autophagy in RF/6A cells. J Cell Physiol. 2019;: pubmed publisher
Cai Q, Wang S, Jin L, Weng M, Zhou D, Wang J, et al. Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagy. Mol Cancer. 2019;18:82 pubmed publisher
Li C, Liu J, Zhang X, Wei S, Huang X, Huang Y, et al. Fish Autophagy Protein 5 Exerts Negative Regulation on Antiviral Immune Response Against Iridovirus and Nodavirus. Front Immunol. 2019;10:517 pubmed publisher
Sharoar M, Hu X, Ma X, Zhu X, Yan R. Sequential formation of different layers of dystrophic neurites in Alzheimer's brains. Mol Psychiatry. 2019;: pubmed publisher
Ji L, Gao J, Kong R, Gao Y, Ji X, Zhao D. Autophagy exerts pivotal roles in regulatory effects of 1α,25-(OH)2D3 on the osteoclastogenesis. Biochem Biophys Res Commun. 2019;511:869-874 pubmed publisher
Pan Y, Li Z, Wang Y, Yan M, Wu J, Beharee R, et al. Sodium fluoride regulates the osteo/odontogenic differentiation of stem cells from apical papilla by modulating autophagy. J Cell Physiol. 2019;: pubmed publisher
Zhao Q, Niu Q, Chen J, Xia T, Zhou G, Li P, et al. Roles of mitochondrial fission inhibition in developmental fluoride neurotoxicity: mechanisms of action in vitro and associations with cognition in rats and children. Arch Toxicol. 2019;93:709-726 pubmed publisher
Zhong S, Li L, Zhang Y, Zhang L, Lu J, Guo S, et al. Acetaldehyde dehydrogenase 2 interactions with LDLR and AMPK regulate foam cell formation. J Clin Invest. 2019;129:252-267 pubmed publisher
Batool S, Joseph T, Hussain M, Vuai M, Khinsar K, Din S, et al. LP1 from Lentinula edodes C91-3 Induces Autophagy, Apoptosis and Reduces Metastasis in Human Gastric Cancer Cell Line SGC-7901. Int J Mol Sci. 2018;19: pubmed publisher
Liu Y, Fan D. Ginsenoside Rg5 induces apoptosis and autophagy via the inhibition of the PI3K/Akt pathway against breast cancer in a mouse model. Food Funct. 2018;9:5513-5527 pubmed publisher
Yu Z, Ma J, Li X, Liu Y, Li M, Wang L, et al. Autophagy defects and related genetic variations in renal cell carcinoma with eosinophilic cytoplasmic inclusions. Sci Rep. 2018;8:9972 pubmed publisher
Chen D, Feng C, Tian X, Zheng N, Wu Z. Promyelocytic Leukemia Restricts Enterovirus 71 Replication by Inhibiting Autophagy. Front Immunol. 2018;9:1268 pubmed publisher
Li Y, Qian W, Wang D, Meng Y, Wang X, Chen Y, et al. Resveratrol relieves particulate matter (mean diameter < 2.5 ?m)-induced oxidative injury of lung cells through attenuation of autophagy deregulation. J Appl Toxicol. 2018;38:1251-1261 pubmed publisher
Cai T, Zhang C, Zhao Z, Li S, Cai H, Chen X, et al. The gastric mucosal protective effects of astragaloside IV in mnng-induced GPL rats. Biomed Pharmacother. 2018;104:291-299 pubmed publisher
Ji J, Xue T, Guo X, Yang J, Guo R, Wang J, et al. Antagonizing peroxisome proliferator-activated receptor γ facilitates M1-to-M2 shift of microglia by enhancing autophagy via the LKB1-AMPK signaling pathway. Aging Cell. 2018;17:e12774 pubmed publisher
Li R, Wang L, Du J, Zhao L, Yao Y. Autophagy activation and the mechanism of retinal microvascular endothelial cells in hypoxia. Int J Ophthalmol. 2018;11:567-574 pubmed publisher
Tsai T, Lai K, Su J, Wu Y, Sheu J. 7-Acetylsinumaximol B Induces Apoptosis and Autophagy in Human Gastric Carcinoma Cells through Mitochondria Dysfunction and Activation of the PERK/eIF2α/ATF4/CHOP Signaling Pathway. Mar Drugs. 2018;16: pubmed publisher
Hu X, Mei S, Meng W, Xue S, Jiang L, Yang Y, et al. CXCR4-mediated signaling regulates autophagy and influences acute myeloid leukemia cell survival and drug resistance. Cancer Lett. 2018;425:1-12 pubmed publisher
Iula L, Keitelman I, Sabbione F, Fuentes F, Guzmán M, Galletti J, et al. Autophagy Mediates Interleukin-1β Secretion in Human Neutrophils. Front Immunol. 2018;9:269 pubmed publisher
Li C, Zhang J, Xu H, Chang M, Lv C, Xue W, et al. Retigabine ameliorates acute stress-induced impairment of spatial memory retrieval through regulating USP2 signaling pathways in hippocampal CA1 area. Neuropharmacology. 2018;135:151-162 pubmed publisher
Wang N, Yang L, Zhang H, Lu X, Wang J, Cao Y, et al. MicroRNA-9a-5p Alleviates Ischemia Injury After Focal Cerebral Ischemia of the Rat by Targeting ATG5-Mediated Autophagy. Cell Physiol Biochem. 2018;45:78-87 pubmed publisher
Sheng Y, Song Y, Li Z, Wang Y, Lin H, Cheng H, et al. RAB37 interacts directly with ATG5 and promotes autophagosome formation via regulating ATG5-12-16 complex assembly. Cell Death Differ. 2018;25:918-934 pubmed publisher
Wang M, Wu H, Li S, Xu Z, Li X, Yang Y, et al. SYNJ2BP promotes the degradation of PTEN through the lysosome-pathway and enhances breast tumor metastasis via PI3K/AKT/SNAI1 signaling. Oncotarget. 2017;8:89692-89706 pubmed publisher
Zhang J, Zhu Y, Shi Y, Han Y, Liang C, Feng Z, et al. Fluoride-Induced Autophagy via the Regulation of Phosphorylation of Mammalian Targets of Rapamycin in Mice Leydig Cells. J Agric Food Chem. 2017;65:8966-8976 pubmed publisher
Liu M, Liang K, Zhen J, Zhou M, Wang X, Wang Z, et al. Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling. Nat Commun. 2017;8:413 pubmed publisher
Wang Y, Zhang X, Tang W, Lin Z, Xu L, Dong R, et al. miR-130a upregulates mTOR pathway by targeting TSC1 and is transactivated by NF-κB in high-grade serous ovarian carcinoma. Cell Death Differ. 2017;24:2089-2100 pubmed publisher
Du C, Zhang T, Xiao X, Shi Y, Duan H, Ren Y. Protease-activated receptor-2 promotes kidney tubular epithelial inflammation by inhibiting autophagy via the PI3K/Akt/mTOR signalling pathway. Biochem J. 2017;474:2733-2747 pubmed publisher
Wang E, Zou B, Shi L, Du L, Zhu Y, Jiang Y, et al. 7-O-geranylquercetin-induced autophagy contributes to apoptosis via ROS generation in human non-small cell lung cancer cells. Life Sci. 2017;180:102-113 pubmed publisher
Li W, Yang X, Zheng T, Xing S, Wu Y, Bian F, et al. TNF-α stimulates endothelial palmitic acid transcytosis and promotes insulin resistance. Sci Rep. 2017;7:44659 pubmed publisher
Cheng X, Zhu L, Zhang J, Yu J, Liu S, Lv F, et al. Anti-osteoclastogenesis of Mineral Trioxide Aggregate through Inhibition of the Autophagic Pathway. J Endod. 2017;43:766-773 pubmed publisher
Xiao Y, Deng Y, Yuan F, Xia T, Liu H, Li Z, et al. ATF4/ATG5 Signaling in Hypothalamic Proopiomelanocortin Neurons Regulates Fat Mass via Affecting Energy Expenditure. Diabetes. 2017;66:1146-1158 pubmed publisher
Jin P, Wei P, Zhang Y, Lin J, Sha R, Hu Y, et al. Autophagy-mediated clearance of ubiquitinated mutant huntingtin by graphene oxide. Nanoscale. 2016;8:18740-18750 pubmed
Sun R, Shen S, Zhang Y, Xu C, Cao Z, Wen L, et al. Nanoparticle-facilitated autophagy inhibition promotes the efficacy of chemotherapeutics against breast cancer stem cells. Biomaterials. 2016;103:44-55 pubmed publisher
Shi Q, Song X, Liu Z, Wang Y, Wang Y, Fu J, et al. Quinones Derived from Polychlorinated Biphenyls Induce ROS-Dependent Autophagy by Evoking an Autophagic Flux and Inhibition of mTOR/p70S6k. Chem Res Toxicol. 2016;29:1160-71 pubmed publisher
Chen J, Liu L, Liu Y, Liu X, Qu C, Meng F, et al. Low-Dose Endothelial-Monocyte-Activating Polypeptide-II Induced Autophagy by Down-Regulating miR-20a in U-87 and U-251 Glioma Cells. Front Cell Neurosci. 2016;10:128 pubmed publisher
Liu S, Zhu L, Zhang J, Yu J, Cheng X, Peng B. Anti-osteoclastogenic activity of isoliquiritigenin via inhibition of NF-κB-dependent autophagic pathway. Biochem Pharmacol. 2016;106:82-93 pubmed publisher
Li S, Zhou A, Wang J, Zhang S. Interplay of autophagy and apoptosis during PRRSV infection of Marc145 cell. Infect Genet Evol. 2016;39:51-54 pubmed publisher
Wei P, Jin P, Barui A, Hu Y, Zhang L, Zhang J, et al. Differential ERK activation during autophagy induced by europium hydroxide nanorods and trehalose: Maximum clearance of huntingtin aggregates through combined treatment. Biomaterials. 2015;73:160-74 pubmed publisher
Yoo B, Zagryazhskaya A, Li Y, Koomson A, Khan I, Sasazuki T, et al. Upregulation of ATG3 contributes to autophagy induced by the detachment of intestinal epithelial cells from the extracellular matrix, but promotes autophagy-independent apoptosis of the attached cells. Autophagy. 2015;11:1230-46 pubmed publisher
Wang L, Yao L, Zheng Y, Xu Q, Liu X, Hu X, et al. Expression of autophagy-related proteins ATG5 and FIP200 predicts favorable disease-free survival in patients with breast cancer. Biochem Biophys Res Commun. 2015;458:816-22 pubmed publisher
Liu M, Xu L, Yin L, Qi Y, Xu Y, Han X, et al. Potent effects of dioscin against obesity in mice. Sci Rep. 2015;5:7973 pubmed publisher
Liu E, Van Grol J, Subauste C. Atg5 but not Atg7 in dendritic cells enhances IL-2 and IFN-γ production by Toxoplasma gondii-reactive CD4+ T cells. Microbes Infect. 2015;17:275-84 pubmed publisher
Zhu X, Ruan Z, Yang X, Chu K, Wu H, Li Y, et al. Connexin 31.1 degradation requires the Clathrin-mediated autophagy in NSCLC cell H1299. J Cell Mol Med. 2015;19:257-64 pubmed publisher
Yuan X, Du J, Hua S, Zhang H, Gu C, Wang J, et al. Suppression of autophagy augments the radiosensitizing effects of STAT3 inhibition on human glioma cells. Exp Cell Res. 2015;330:267-76 pubmed publisher
product information
CatalogNo :
10181-2-AP
AntigenName :
ATG5
Package :
150UL
Price :
299 USD
Exsists20ul :
20ul trial size available
FullName :
ATG5 autophagy related 5 homolog (S. cerevisiae)
Immunogen :
Recombinant Protein
Species :
grouper, human, monkey, mouse, rat, swine
Host :
Rabbit
IsConjugated :
Unconjugated
AntigenSpecies :
human
Application :
WB, IHC, IF, FC, ELISA
Clonlity :
Polyclonal
IsoType :
IgG
Synonyms :
APG5, APG5 LIKE, APG5L, Apoptosis specific protein, ASP, ATG5, Autophagy protein 5, hAPG5
PrimaryOrSecondary :
Primary
AntibodyBuffer :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
GenBankNo :
BC002699
Category :
Apoptosis;Autophagy;Binding Proteins;Cytoskeleton/Scaffold Proteins;Metabolism;
PurifyMethod :
Antigen affinity purification
NewAb :
False
IsSellable :
True
Feature :
siRNA
AppTiter :
IF 1:50 ; IHC 1:200 ; WB 1:1000 ;
company information
Proteintech Group
2201 W. Campbell Park Dr. STE12
Chicago, IL 60612
Proteintech@ptglab.com
https://www.ptglab.com
1-312-455-8498
headquarters: USA
At Proteintech, we produce every single antibody we sell; we do not rely on or supply to any other antibody providers: our products are unique and we are 100% accountable for each one. We realize this accountability by validating in-house, providing extensive technical support and guaranteeing your success: in addition to helping you troubleshoot your experiment, we will offer you a full cash refund if you are in any way dissatisfied. We can guarantee satisfaction because we have confidence in our products, confidence cultivated by the science behind our antibodies: we make them using as much of the native protein as possible, and purifying them using affinity purification with the original antigen. We carry out antibody production over a 102-day period, which allows for better antigen fitting to MHC molecules and affinity maturation in the host. This approach results in higher affinity antibodies with greater sensitivity, which you can use in any application and in multiple species.
You can only buy Proteintech antibodies directly from Proteintech or via one of its approved distributors — when you receive your antibody and see the Proteintech logo on the vial, know that you hold something that is truly unique.