KLF4 Antibody [4E5C3] | ProSci PM-6142 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProSci

product type :

antibody

product name :

KLF4 Antibody [4E5C3]

catalog :

PM-6142

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4E5C3

The same clone is also sold as:

OriGene: TA326715
Abnova: MAB11171
LifeSpan Biosciences: LS-C144496

reactivity :

human, mouse, rat

application :

western blot, ELISA

product information

Catalog Number :

PM-6142

Product Name :

KLF4 Antibody [4E5C3]

Host Species :

Mouse

Clonality :

Monoclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Clone :

4E5C3

Isotype :

IgG1

CrossReactivity :

Human, Mouse, Rat

Background :

KLF4 Monoclonal Antibody: KLF4 is a transcription factor that functions as both a transcriptional activator and repressor to regulate proliferation and differentiation of multiple cell types. The role of KLF4 in embryonic development suggested that it might be useful in the creation of stem cells that might be useful in cell replacement therapies in the treatment of several degenerative diseases. Artificial stem cells, termed induced pluripotent stem (iPS) cells, can be created by expressing KLF4 and the transcription factors POU5F1, Sox2, and Lin28 along with c-Myc in mouse fibroblasts. More recently, experiments have demonstrated that iPS cells could be generated using expression plasmids expressing KLF4, Sox2, POU5F1 and c-Myc, eliminating the need for virus introduction, thereby addressing a safety concern for potential use of iPS cells in regenerative medicine. KLF4 interacts directly with POU5F1 and Sox2 in iPS and ES cells and activates the target gene NANOG.

ALTnames :

KLF4 Antibody [4E5C3] : EZF, GKLF

Immunogen :

KLF4 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of human KLF4.

Specificity :

At least three isoforms of KLF4 are known to exist; this antibody will detect all three. KLF4 antibody will not cross-react with other Kruppel-like family members.

Purity :

KLF4 Monoclonal Antibody is affinity chromatography purified via peptide column.

Buffer :

KLF4 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration :

1 mg/mL

Uses :

E, WB

Application Summary :

KLF4 antibody can be used for detection of KLF4 by Western blot at 1 g/mL.

Storage :

KLF4 monoclonal antibody can be stored at -20 C, stable for one year.

General References :

Evans PM, Zhang W, Chen X, et al. Kruppel-like factor 4 is acetylated by p300 and regulates gene transcription via modulation of histone acetylation. J. Bio. Chem. 2007; 282:33994-4002.

General References :

Carpenter MK, Rosler E, and Rao MS. Characterization and differentiation of human embryonic stem cells. Cloning Stem Cells 2003; 5:79-88.

General References :

Takahashi K and Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006; 1263:663-76.

General References :

Okita K, Nakagawa M, Hyenjong H, et al. Generation of mouse induced pluripotent stem cells without viral vectors. Science 2008; 322:949-53.