PD-1 Antibody [12A7D7] | ProSci PM-5179 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProSci

product type :

antibody

product name :

PD-1 Antibody [12A7D7]

catalog :

PM-5179

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

12A7D7

The same clone is also sold as:

Abnova: MAB8089
OriGene: TA319693
MyBioSource: MBS150009
Invitrogen: MA5-15781
LifeSpan Biosciences: LS-C144488

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry

product information

Catalog Number :

PM-5179

Product Name :

PD-1 Antibody [12A7D7]

Host Species :

Mouse

Clonality :

Monoclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Clone :

12A7D7

Isotype :

IgG1

CrossReactivity :

Human, Mouse, Rat

Background :

PD-1 Monoclonal Antibody: Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antig en-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. Despite its predicted molecular weight, PD-1 often migrates at higher molecular weight in SDS-PAGE.

ALTnames :

PD-1 Antibody [12A7D7] : PD1, PD-1, CD279, SLEB2, hPD-1, hPD-l, hSLE1

Immunogen :

A ~150 amino acid recombinant protein from near the amino terminus of mouse PD-1.

Purity :

PD-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Buffer :

PD-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration :

1 mg/mL

Uses :

E, WB, IHC

Application Summary :

PD-1 antibody can be used for detection of PD-1 by Western blot at 1 g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 g/mL.

Storage :

PD-1 monoclonal antibody can be stored at -20 C, stable for one year.

General References :

Holling TM, Schooten E, and van Den Elsing PJ. Function and regulation of MHC class II molecules in T-lymphocytes: of mice and men. Hum. Immunol. 2004; 65:282-90.

General References :

Ishida Y, Agata Y, Shibahara K, et al. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J. 1992; 11:3887-95.

General References :

Zhong X, Bai C, Gao W, et al. Suppression of expression and function of negative immune regulator PD-1 by certain pattern recognition and cytokine receptor signals associated with immune system danger. Int. Immunol. 2004; 16:1181-8.

General References :

Nishimura H, Nose M, Hiai H, et al. Development of lupus-like autoimmune diseases by the disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity 1999; 11:141-51.