This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ProSci
product type :
antibody
product name :
MD-2 Antibody [9F1B1]
catalog :
PM-4845
quantity :
0.02 mg, 0.1 mg
price :
79, 315 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
9F1B1

The same clone is also sold as:
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
product information
Catalog Number :
PM-4845
Product Name :
MD-2 Antibody [9F1B1]
Host Species :
Mouse
Clonality :
Monoclonal
Conjugation :
Unconjugated
Product Type :
Primary Antibody
Size :
0.02 mg, 0.1 mg
List Price :
79, 315 USD
Clone :
9F1B1
Isotype :
IgG1
CrossReactivity :
Human, Mouse
Background :
MD-2 Monoclonal Antibody: MD-2 is a member of the Toll/interleukin-1 receptor (TIR) family, a group of proteins that include the Toll-like receptors (TLRs). TLRs are signaling molecules that recognize different pathogen-associated molecular patterns (PAMPs) and serve as an important link between the innate and adaptive immune responses. TLR4, the major signaling receptor for lipopolysaccharide (LPS), requires the binding of MD-2 to its extracellular region for maximal response to LPS. The specificity of this response is determined by the species of MD-2; e.g., human MD-2 transfected into mouse cells can cause mouse TLR4 to react to LPS analogs that are normally antagonistic to human but not mouse TLR4.
ALTnames :
MD-2 Antibody [9F1B1] : MD2, MD-2, ly-96, ESOP-1
Immunogen :
Mouse monoclonal MD-2 antibody was raised against a recombinant protein corresponding to amino acids 2 to 160 of human MD-2
Purity :
MD-2 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Buffer :
MD-2 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration :
1 mg/mL
Uses :
E, WB, IHC, IF
Application Summary :
MD-2 antibody can be used for detection of MD-2 by Western blot at 1 g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 g/mL. For immunofluorescence start at 20 g/mL.
Storage :
MD-2 monoclonal antibody can be stored at -20 C, stable for one year.
General References :
O’Neill LAJ, Fitzgerald FA, and Bowie AG. The Toll-IL-1 receptor adaptor family grows to five members. Trends in Imm. 2003; 24:286-9.
General References :
Vogel SN, Fitzgerald KA, and Fenton MJ. TLRs: differential adapter utilization by toll-like receptors mediates TLR-specific patterns of gene expression. Mol. Interv. 2003; 3:466-77.
General References :
Takeda K, Kaisho T, and Akira S. Toll-like receptors. Annu. Rev. Immunol. 2003; 21:335-76.
General References :
Janeway CA Jr and Medzhitov R. Innate immune recognition. Annu. Rev. Immunol. 2002; 20:197-216.
company information
ProSci
12170 Flint Place
Poway, CA 92064
orders@prosci-inc.com
www.prosci-inc.com
1-888-513-9525
headquarters: USA