This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ProSci
product type :
antibody
product name :
MyD88 Antibody [2E9C2]
catalog :
PM-4673
quantity :
0.02 mg, 0.1 mg
price :
79, 315 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2E9C2

The same clone is also sold as:
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
product information
Catalog Number :
PM-4673
Product Name :
MyD88 Antibody [2E9C2]
Host Species :
Mouse
Clonality :
Monoclonal
Conjugation :
Unconjugated
Product Type :
Primary Antibody
Size :
0.02 mg, 0.1 mg
List Price :
79, 315 USD
Clone :
2E9C2
Isotype :
IgG2b
CrossReactivity :
Human, Mouse
Background :
MyD88 Monoclonal Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires IL-1 receptor complex including IL-1RI and IL-1RAcP. MyD88 has been identified as an adapter molecule in the IL-1 signaling pathway. MyD88 associates with and recruits IRAK to the IL-1 receptor complex in response to IL-1 treatment and dominant negative form of MyD88 attenuates IL-1R-mediated NF- B activation. MyD88 is also employed as a regulator molecule by IL-18 receptor and human Toll receptor, which are members in the Toll/IL-1R family of receptors. Targeted disruption of the MyD88 gene results in lose of cellular responses to IL-1 and IL-18, and MyD88-deficient mice lack responses to bacterial product LPS that employs Toll-like receptors 2 and 4 (TLR2 and TLR4) as the signaling receptors. MyD88 is a general adapter protein for the Toll/IL-1R family of receptors and plays an important role in the inflammatory response induced by cytokines IL-1 and IL-18 and endotoxin. MyD88 gene is expressed in many tissues.
ALTnames :
MyD88 Antibody [2E9C2] : MYD88D
Immunogen :
Mouse monoclonal MyD88 antibody was raised against a recombinant protein corresponding to amino acids 176 to 280 of human MyD88.
Purity :
MyD88 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
Buffer :
MyD88 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration :
1 mg/mL
Uses :
E, WB, IHC, IF
Application Summary :
MyD88 antibody can be used for detection of MyD88 by Western blot at 2 g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 g/mL. For immunofluorescence start at 20 g/mL.
Storage :
MyD88 monoclonal antibody can be stored at -20 C, stable for one year.
General References :
Muzio M, Ni J, Feng P, et al. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997; 278:1612-5.
General References :
Adachi O, Kawai T, Takeda K, et al. Targeted disruption of the MyD88 gene results in loss of IL-1- and IL-18-mediated function. Immunity 1998; 9:143-50.
General References :
Medzhitov R, Preston-Hurlburt P, Kopp E, et al. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 1998; 2:253-8.
General References :
Kawai T, Adachi O, Ogawa T, et al. Unresponsiveness of MyD88-deficient mice to endotoxin. Immunity 1999; 11:115-22.
company information
ProSci
12170 Flint Place
Poway, CA 92064
orders@prosci-inc.com
www.prosci-inc.com
1-888-513-9525
headquarters: USA