DC-SIGN Antibody [5D7] | ProSci PM-2347 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProSci

product type :

antibody

product name :

DC-SIGN Antibody [5D7]

catalog :

PM-2347

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

5D7

The same clone is also sold as:

Abnova: MAB2748
MyBioSource: MBS150015
OriGene: TA319909
Invitrogen: MA5-15745

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog Number :

PM-2347

Product Name :

DC-SIGN Antibody [5D7]

Host Species :

Mouse

Clonality :

Monoclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Clone :

5D7

CrossReactivity :

Human

Background :

DC-SIGN Monoclonal Antibody: Dendritic cells (DCs) that control immune responses were recently found to capture and transport HIV from the mucosal area to remote lymph nodes, where DCs hand over HIV to CD4+ T lymphocytes. DCs also amplify the amount of virus and extend the duration of viral infectivity. Multiple strains of HIV-1, HIV-2 and SIV bind to DCs via DC-SIGN. ICAM-3 is the natural ligand for DC-SIGN. A DC-SIGN homologue (termed DC-SIGNR, L-SIGN, and DC-SIGN2) was identified recently. DC-SIGN forms a novel gene family with DC-SIGNR and many alternatively spliced isoforms of DC-SIGN and DC-SIGNR. The expression of DC-SIGN was found in mucosal tissues including placenta, small intestine, and rectum.

ALTnames :

DC-SIGN Antibody [5D7] : CDSIGN, CLEC4L, DC-SIGN, DC-SIGN1

Immunogen :

A recombinant His-tagged protein fragment corresponding to the extracellular region of human DC-SIGN.

Purity :

DC-SIGN Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Buffer :

DC-SIGN Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration :

1 mg/mL

Uses :

E, WB, IHC

Application Summary :

DC-SIGN antibody can be used for detection of DC-SIGN in Western Blot at 1 - 2 mg/mL and in immunohistochemistry at 5 - 10 mg/mL.

Storage :

DC-SIGN monoclonal antibody can be stored at -20 C, stable for one year.

General References :

Geijtenbeek TB, Kwon DS, Torensma R, et al. DC-SIGN, a dendritic cell-specific HIV-1-binding protein that enhances trans-infection of T cells. Cell 2000; 100:587-97.

General References :

Pohlmann S, Baribaud F, Lee B, et al. DC-SIGN interactions with human immunodeficiency virus type 1 and 2 and simian immunodeficiency virus. J. Virol. 2001;75:4664-72.

General References :

Geijtenbeek TB, Torensma R, van Vliet SJ, et al. Identification of DC-SIGN, a novel dendritic cell-specific ICAM-3 receptor that supports primary immune responses. Cell 2000; 100:575-85.

General References :

Soilleux EJ, Barten R, Trowsdale J. DC-SIGN; a related gene, DC-SIGNR; and CD23 form a cluster on 19p13. J. Immunol. 2000; 165:2937-42.