AKT1 / AKT2 / AKT3 (Ab 315 / 316 / 312) Antibody | ProSci 79-417 product information

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product summary

company name :

ProSci

product type :

antibody

product name :

AKT1 / AKT2 / AKT3 (Ab 315 / 316 / 312) Antibody

catalog :

79-417

quantity :

0.1 mg

price :

275 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunohistochemistry

product information

Catalog Number :

79-417

Product Name :

AKT1 / AKT2 / AKT3 (Ab 315 / 316 / 312) Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Antigen Modification :

Phospho-Specific

Product Type :

Primary Antibody

Size :

0.1 mg

List Price :

275 USD

CrossReactivity :

Human, Mouse, Rat

Background :

General protein kinase capable of phosphorylating several known proteins. Phosphorylates TBC1D4. Signals downstream of phosphatidylinositol 3-kinase (PI3K) to mediate the effects of various growth factors such as platelet-derived growth factor (PDGF), epidermal growth factor (EGF), insulin and insulin-like growth factor I (IGF-I). Plays a role in glucose transport by mediating insulin-induced translocation of the GLUT4 glucose transporter to the cell surface. Mediates the antiapoptotic effects of IGF-I. Mediates insulin-stimulated protein synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462', thereby activating mTORC1 signaling and leading to both phosphorylation of 4E-BP1 and in activation of RPS6KB1. Promotes glycogen synthesis by mediating the insulin-induced activation of glycogen synthase. /General protein kinase capable of phosphorylating several known proteins. /IGF-1 leads to the activation of AKT3, which may play a role in regulating cell survival. Capable of phosphorylating several known proteins. Truncated isoform 2/PKB gamma 1 without the second serine phosphorylation site could still be stimulated but to a lesser extent.

ALTnames :

AKT, PKB, RAC, CWS6, PRKBA, PKB-ALPHA, RAC-ALPHA, P53, RAC-PK-alpha, Protein kinase B

Immunogen :

AKT1/AKT2/AKT3 (Ab-315/316/312) antibody was raised against a peptide sequence around aa.313~317/314~318/310~314 (P-E-Y-L-A) derived from Human AKT1/AKT2/AKT3.

Specificity :

This antibody detects endogenous level of total AKT1/AKT2/AKT3 protein.

Purity :

Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Buffer :

Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Concentration :

1 mg/mL

Uses :

IHC

Application Summary :

Immunohistochemistry: 1:50~1:100

Storage :

Store antibody at -20 C for up to one year.

General References :

Nelms K, et al. (1999) Annu Rev Immunol. 17:701-738. Malabarba M G, et al. (1996) Biochem. J. 319:865-872. Hou J, et al. (1994) Science. 265:1701-1706. Quelle F W, et al. (1995) Mol Cell Biol. 15: 3336-3343. Takeda K, et al. (1996) Nature. 380: 627-630.