WIZ Antibody | ProSci 6117 product information

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product summary

company name :

ProSci

product type :

antibody

product name :

WIZ Antibody

catalog :

6117

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

product information

Catalog Number :

6117

Product Name :

WIZ Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human, Mouse, Rat

Background :

WIZ Antibody: WIZ, also known as ZNF803, was initially identified in a mouse cerebellum cDNA library screen and its message was found to be expressed in the granule cell layers of the cerebellum as well as in the dentate gyrus and olfactory bulb. Later analysis indicates however that WIZ is ubiquitously expressed. WIZ is a nuclear protein that co-localizes with G9a, a histone methyltransferase responsible for mono- and dimethylation of H3K9 at euchromatic regions. WIZ can also associate with CtBP family proteins, known to be transcriptional co-repressors, and has been suggested to link G9a/GLP complexes to the CtBP co-repressor machinery, possibly regulating complex stability and gene silencing.

ALTnames :

WIZ Antibody: ZNF803, ZNF803, Protein Wiz, Widely-interspaced zinc finger-containing protein

Immunogen :

WIZ antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of human TFF3.

Specificity :

At least four isoforms of WIZ are known to exist; this antibody will detect all four.

Purity :

WIZ Antibody is affinity chromatography purified via peptide column.

Buffer :

WIZ Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration :

1 mg/mL

Uses :

E, WB, IHC, IF

Application Summary :

WIZ antibody can be used for detection of WIZ by Western blot at 1 g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 g/mL. For immunofluorescence start at 20 g/mL.

Storage :

WIZ antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Matsumoto K, Ishii N, Yoshida S, et al. Molecular cloning and distinct developmental expression pattern of spliced forms of a novel zinc finger gene wiz in the mouse cerebellum. Brain Res. Mol. Brain Res.1998; 61:179-89.

General References :

Ueda J, Tachibana M, Ikura T, et al. Zinc finger protein Wiz links G9a/GLP histone methyltransferases to the co-repressor molecule CtBP. J. Biol. Chem.2006; 281:20120-8.