IFITM1 Antibody | ProSci 5807 product information

product summary

company name :

ProSci

product type :

antibody

product name :

IFITM1 Antibody

catalog :

5807

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry

more info or order :

ProSci product webpage

citations: 4

Published Application/Species/Sample/Dilution	Reference
western blot; human; 4 ug/ml; fig s7c	Wu W, Grotefend C, Tsai M, Wang Y, Radic V, Eoh H, et al. ?20 IFITM2 differentially restricts X4 and R5 HIV-1. Proc Natl Acad Sci U S A. 2017;114:7112-7117 pubmed publisher
	Williams D, Wu W, Grotefend C, Radic V, Chung C, Chung Y, et al. IFITM3 polymorphism rs12252-C restricts influenza A viruses. PLoS ONE. 2014;9:e110096 pubmed publisher
	John S, Chin C, Perreira J, Feeley E, Aker A, Savidis G, et al. The CD225 domain of IFITM3 is required for both IFITM protein association and inhibition of influenza A virus and dengue virus replication. J Virol. 2013;87:7837-52 pubmed publisher
	Everitt A, Clare S, Pertel T, John S, Wash R, Smith S, et al. IFITM3 restricts the morbidity and mortality associated with influenza. Nature. 2012;484:519-23 pubmed publisher

product information

Catalog Number :

5807

Product Name :

IFITM1 Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human, Mouse, Rat

Background :

IFITM1 Antibody: IFITM1 (Interferon inducible transmembrane protein 1) is a member of the IFN-inducible transmembrane protein family. It is an essential mediator of interferon-gamma-induced antiproliferation and plays a role in the control of cell growth. IFITM1 is upregulated in several tumor types and may be useful as a tumor biomarker. Both mouse IFITM1 and IFITM3 are expressed on the cell surfaces of primordial germ cells in a developmentally-regulated manner. IFITM1 activity is required for primordial germ cell transit, and IFITM1 acts as a repulsive molecule by repelling non-IFITM1-expressing primordial germ cells from the mesoderm into the endoderm.

ALTnames :

IFITM1 Antibody: 9-27, CD225, IFI17, LEU13, DSPA2a, Interferon-induced transmembrane protein 1, Dispanin subfamily A member 2a

Immunogen :

IFITM1 antibody was raised against a 16 amino acid synthetic peptide near the center of human IFITM1.

Purity :

IFITM1 Antibody is affinity chromatography purified via peptide column.

Buffer :

IFITM1 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration :

1 mg/mL

Uses :

E, WB, ICC, IF

Application Summary :

IFITM1 antibody can be used for detection of IFITM1 by Western blot at 1 - 2 g/mL. Antibody can also be used for immunocytochemistry starting at 20 g/mL. For immunofluorescence start at 20 g/mL.

Storage :

IFITM1 antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Deblandre GA, Marinx OP, Evans SS, et al. Expression cloning of an interferon-inducible 17 kDa membrane protein implicated in the control of cell growth. J. Biol. Chem.1995; 270:23860-6.

General References :

Yang G, Xu Y, Chen X, et al. IFITM1 plays an essential role in the antiproliferative action of interferon-gamma. Oncogene.2007; 26:594-603.

General References :

Akyerli CB, Beksac M, Holko M, et al. Expression of IFITM1 in chronic myeloid leukemia patients. Leuk. Res.2005; 29:283-6.

General References :

Tanaka SS, Yamaguchi YL, Tsoi B, et al. IFITM/Mil/Fragilis family proteins IFITM1 and IFITM3 play distinct roles in mouse primordial germ cell homing and repulsion. Cell 2005; 9:745-6.

more info or order :

ProSci product webpage