RSPO1 Antibody | ProSci 5171 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProSci

product type :

antibody

product name :

RSPO1 Antibody

catalog :

5171

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

product information

Catalog Number :

5171

Product Name :

RSPO1 Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human, Mouse, Rat

Background :

RSPO1 Antibody: RSPO1 is a member of a family of secreted growth factors that can operate through the canonical Wnt signaling pathway by stabilizing the intracellular beta-catenin, thereby regulating functions mediated by beta-catenin such as cell fate decisions and embryonic patterning. RSPO1 was recently identified through linkage analysis to be involved in sex determination and mammalian ovarian development. RSPO1 is thought to regulate cellular responsiveness to Wnt ligands by modulating the cell-surface expression of the Wnt co-receptor LRP6 by interfering with the DKK/Kremen-mediated internalization of LRP6 through an interaction with Kremen, resulting in increased LRP6 cell-surface levels. At least two isoforms of RSPO1 are known to exist. RSPO1 antibody will not cross-react with RSPO family members.

ALTnames :

RSPO1 Antibody: RSPO, CRISTIN3, R-spondin-1, Roof plate-specific spondin-1, hRspo1

Immunogen :

RSPO1 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human RSPO1.

Purity :

RSPO1 Antibody is affinity chromatography purified via peptide column.

Buffer :

RSPO1 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration :

1 mg/mL

Uses :

E, WB, IHC, IF

Application Summary :

RSPO1 antibody can be used for detection of RSPO1 by Western blot at 1 - 2 g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 g/mL. For immunofluorescence start at 20 g/mL.

Storage :

RSPO1 antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Kamata T, Katsube K, Michikawa M, et al. R-spondin, a novel gene with thrombospondin type I domain, was expressed in the dorsal neural tube and affected Wnts mutants. Biochim. Biophys. Acta2004; 1676:51-61.

General References :

Kim KA, Zhao J, Andarmani S, et al. R-spondin proteins: a novel link to beta-catenin signaling. Cell Cycle2006; 5:23-6.

General References :

Parma P, Radi O, Vidal V, et al. R-spondin1 is essential in sex determination, skin differentiation and malignancy. Nat. Genet.2006; 38:1304-9.

General References :

Chassot AA, Ranc F, Gregoire EP, et al. Activation of b-catenin signalling by Rspo1 controls differentiation of the mammalian ovary. Hum. Mol. Genet.2008; 17:1278-91.