antibody

Choline Acetyltransferase Antibody

50-265

0.1 mL

330 USD

polyclonal

goat

nonconjugated

human, mouse, rat, chicken, Rhesus monkey

western blot, immunohistochemistry

Choline Acetyltransferase Antibody

Goat

Polyclonal

Unconjugated

Primary Antibody

0.1 mL

330 USD

Human, Mouse, Rat, Goat, Chicken

Choline acetyltransferase is a neuronal enzyme which catalyzes the reaction between Acetyl CoA and choline resulting in the formation of acetylcholine. It is therefore found primarily in cholinergic neurons making it a valuable marker for diseases associated with decreased cholinergic function such as Schizophrenia, Alzheimer disease (AD) and Down syndrome (Holt et al. 1999). Decreased choline acetyltransferase activity in particular has been shown in Schizophrenic subjects (Karson et al 1993). It has furthermore been demonstrated that in patients with AD, there are significantly lower levels of cortical ChAT that correlate with severity of the disease as measured by loss of neuropsychological function (Baskin et al. 1999).

CMS1A, CMS1A2, CHOACTASE, CHOACTase

Native choline acetyltransferase purified from human placenta.

Specific for the ~ 70k choline acetyltransferase protein

Affinity Purified

100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.

WB, IHC

Choline Acetyltransferase antibody can be stored at -20 C and is stable at -20 C for at least 1 year.

Karson CN, Casanova MF, Kleinman JE, Griffin WS (1993) Choline acetyltransferase in schizophrenia. Am. J.Psychiatry 150:454-459.

Holt DJ, Herman MM, Hyde TM, Kleinman JE, Cinton CM, German DC, Hersh LB, Greybiel AM, Saper CB (1999) Evidence for a deficit in cholinergic interneurons in the striatum in schizophrenia. Neuroscience 94(1):21-31.

Baskin DS, Browning JL, Pirozzolo FJ, Korporaal S, Baskin JA, Appel SH (1999) Brain choline acetyltransferase and mental function in Alzheimer disease. Arch Neurol. 56:1121-1123.