Tyrosine Hydroxylase Antibody | ProSci 50-262 product information

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product summary

company name :

ProSci

product type :

antibody

product name :

Tyrosine Hydroxylase Antibody

catalog :

50-262

quantity :

0.1 mL

price :

330 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

rat

application :

western blot, immunohistochemistry, immunocytochemistry

product information

Catalog Number :

50-262

Product Name :

Tyrosine Hydroxylase Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.1 mL

List Price :

330 USD

CrossReactivity :

Mammal

Background :

Tyrosine hydroxylase (TH) is the rate-limiting enzyme in the synthesis of the catecholamines dopamine and norepinephrine. TH antibodies can therefore be used as markers for dopaminergic and noradrenergic neurons in a variety of applications including depression, schizophrenia, Parkinson’s disease and drug abuse (Kish et al., 2001; Zhu et al., 2000; Zhu et al., 1999). TH antibodies can also be used to explore basic mechanisms of dopamine and norepinephrine signaling (Witkovsky et al., 2000; Salvatore et al., 2001; Dunkley et al., 2004).

ALTnames :

The, Tyrosine 3-hydroxylase, TH

Immunogen :

SDS-denatured rat tyrosine hydroxylase, purified from pheochromocytoma.

Specificity :

Specific for the ~60k tyrosine hydroxylase protein.

Purity :

Affinity Purified

Buffer :

100 uL in 10 mM HEPES (pH 7.5), 150 mM NaCl, 100 ug per mL BSA and 50% glycerol.

Uses :

WB, IF, IHC

Storage :

Tyrosine Hydroxylase antibody can be stored at -20 C and is stable at -20 C for at least 1 year.

General References :

Dunkley PR, Bobrovskaya L, Graham ME, Von Nagy-Felsobuki EI, Dickson PW (2004) Tyrosine hydroxylase phosphorylation: regulation and consequences. J Neurochem 91:1025-1043.

General References :

Kish SJ, Kalasinsky KS, Derkach P, Schmunk GA, Guttman M, Ang L, Adams V, Furukawa Y, Haycock JW (2001) Striatal dopaminergic and serotonergic markers in human heroin users. Neuropsychopharmacology 24:561-567.

General References :

Salvatore MF, Waymire JC, Haycock JW (2001) Depolarization-stimulated catecholamine biosynthesis: involvement of protein kinases and tyrosine hydroxylase phosphorylation sites in situ. J Neurochem 79:349-360.