Myeloperoxidase Antibody | ProSci 49-451 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProSci

product type :

antibody

product name :

Myeloperoxidase Antibody

catalog :

49-451

quantity :

0.05 mL

price :

350 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation

product information

Catalog Number :

49-451

Product Name :

Myeloperoxidase Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.05 mL

List Price :

350 USD

CrossReactivity :

Human

Background :

Human myeloperoxidase (MPO) is a dimeric protein composed of two heavy subunits (53 kDa) and two light subunits (15 kDa). Each MPO molecule contains two prosthetic porphyrins which play an important role in the catalytic cycle. Molecular weights for MPO isoforms from pools of normal human samples range from 114,000 to 140,000 daltons reflecting a heterogeneous mixture of isoforms when assayed under non-reducing conditions of SDS-PAGE. Often MPO from a single donor will yield a homogenous preparation reflecting a single isoform. The carbohydrate component of MPO, consisting of mannose, glucose and N-acetylglucosamine residues is 2.5%. MPO is inhibited by azide and other compounds. MPO is stored in primary granules of neutrophils and serves as a bactericidal agent in that MPO catalyzes the production of hypochlorous acid (HOCl), a powerful oxidant. HOCl is derived from chloride ion (Cl-) and hydrogen peroxide (H2O2). In a number of inflammatory situations, MPO is released into the extracellular matrix where its measurement can be used as an indication of neutrophil activation.

ALTnames :

MPO, Myeloperoxidase precursor, Myeloperoxidase

Immunogen :

Myeloperoxidase antibody was raised against amino acids 3 - 14 of Myeloperoxidase (Human).

Purity :

Delipidation and Defibrination

Buffer :

PBS, pH 7.2, 0.01% sodium azide.

Uses :

E, WB, IHC, IF, IP

Application Summary :

Myeloperoxidase antibody can be used in immunohistochemistry starting at 10 g/mL.

Storage :

Store Myeloperoxidase antibody at 4 C or -20 C. As with all antibodies avoid freeze/thaw cycles.