CRTC1 Antibody | ProSci 49-411 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProSci

product type :

antibody

product name :

CRTC1 Antibody

catalog :

49-411

quantity :

0.05 mg

price :

350 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, cow, zebrafish

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

product information

Catalog Number :

49-411

Product Name :

CRTC1 Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.05 mg

List Price :

350 USD

CrossReactivity :

Bovine, Human, Mouse, Pufferfish, Rat, Zebrafish

Background :

MECT1 (also known as MucoEpidermoid Carcinoma Translocated 1, Transducer of regulated cAMP response element-binding protein 1, TORC1, and Transducer of CREB protein 1) is a nuclear protein that functions as a transcriptional coactivator for CREB1, which activates transcription through both consensus and variant cAMP response element (CRE) sites. MECT1does not appear to modulate CREB1 DNA-binding activity but enhances the interaction of CREB1 with TAF4/TAFII-130. MECT1 translocates with MAML2 (MasterMind-Like Protein 2) to yield a fusion oncogene: t(11;19) (q21;p13). This translocation occurs in mucoepidermoid carcinomas, benign Warthin tumors and clear cell hidradenomas. The novel fusion product that results disrupts the Notch signaling pathway. The fusion protein consists of the N-terminus of MECT1 joined to the C-terminus of MAML2. The reciprocal fusion protein consisting of the N-terminus of MAML2 joined to the C-terminus of MECT1 has been detected in a small number of mucoepidermoid carcinomas. Multiple isoforms have been reported for the MECT1 protein.

ALTnames :

CRTC1, KIAA0616, MECT1, TORC-1, TORC1, Transducer of CREB protein 1, WAMTP1

Immunogen :

CRTC1 antibody was raised against amino acids 19 - 34 of CRTC1 (Human).

Purity :

Immunoaffinity Chromatography

Buffer :

0.02 M potassium phosphate, 0.15 M sodium chloride, pH 7.2, 0.01% sodium azide.

Uses :

E, WB, IHC, IF

Application Summary :

CRTC1 antibody can be used in ELISA starting at 1:14000 - 1:80000, Western Blot starting at 1:100 - 1:8000, immunohistochemistry starting at 5 g/mL, and immunofluorescence.

Storage :

Store CRTC1 antibody at 4 C or -20 C. As with all antibodies avoid freeze/thaw cycles.