Grik5 Antibody | ProSci 4397 product information

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product summary

company name :

ProSci

product type :

antibody

product name :

Grik5 Antibody

catalog :

4397

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

product information

Catalog Number :

4397

Product Name :

Grik5 Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human, Mouse, Rat

Background :

Grik5 Antibody: Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik5, also known as kainate-preferring glutamate recptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik5 is highly homologous to the related ionotrophic glutamate receptor Grik4 (also known as KA1). Like Grik4, Grik5 does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1-null mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface.

ALTnames :

Grik5 Antibody: KA2, EAA2, GRIK2, GluK5, Glutamate receptor ionotropic, kainate 5, Excitatory amino acid receptor 2

Immunogen :

Grik5 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human Grik5.

Specificity :

This Grik5 antibody does not cross-react with Grik4.

Purity :

Grik5 Antibody is affinity chromatography purified via peptide column.

Buffer :

Grik5 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration :

1 mg/mL

Uses :

E, WB, IHC, IF

Application Summary :

Grik5 antibody can be used for detection of Grik5 by Western blot at 0.5 - 2 g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 g/mL. For immunofluorescence start at 20 g/mL.

Storage :

Grik5 antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Tanaka K. Functions of glutamate transports in the brain. Neurosci. Res.2000; 37:15-9.

General References :

Herb A, Burnashev N, Werner P, et al. The KA-2 subunit of excitatory amino acid receptors shows widespread expression in brain and forms ion channels with distantly related subunits. Neuron1992; 8:775-85.

General References :

Pinheiro P and Mulle C. Kainate receptors. Cell Tissue Res.2006; 326:457-82.

General References :

Nasu-Nishimura Y, Hurtado D, Braud S, et al. Tification of an endoplasmic reticulum-retention motif in an intracellular loop of the kainate receptor subunit KA2. J. Neurosci.2006; 26:7014-21.