CDNF Antibody | ProSci 4343 product information

product summary

company name :

ProSci

product type :

antibody

product name :

CDNF Antibody

catalog :

4343

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - free floating section

more info or order :

ProSci product webpage

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - free floating section; human; 1:10 000	Bäck S, Peranen J, Galli E, Pulkkila P, Lonka-Nevalaita L, Tamminen T, et al. Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease. Brain Behav. 2013;3:75-88 pubmed publisher
	Garea-Rodríguez E, Eesmaa A, Lindholm P, Schlumbohm C, König J, Meller B, et al. Comparative Analysis of the Effects of Neurotrophic Factors CDNF and GDNF in a Nonhuman Primate Model of Parkinson's Disease. PLoS ONE. 2016;11:e0149776 pubmed publisher

product information

Catalog Number :

4343

Product Name :

CDNF Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human, Mouse, Rat

Background :

CDNF Antibody: The conserved dopamine neurotrophic factor (CDNF) is a neurotrophic factor for dopaminergic neurons and highly homologous to the mesencephalic-astrocyte-derived neuro-trophic factor. Somewhat surprisingly, CDCF is expressed at higher levels in tissues such as heart, skeletal muscle and testes than in brain. Similar to the glial cell line-derived neurotrophic factor (GDNF), CDNF can prevent the 6-hydroxylamine (6-OHDA)-induced degeneration of dopaminergic neurons in a rat model of Parkinson's disease. Furthermore, CDNF was able to restore the dopaminergic function and prevent the degeneration of dopaminergic neurons in the substantia nigra, suggesting that CDNF might be suitable for the treatment of Parkinson's disease. At least two isoforms of CDNF are known to exist.

ALTnames :

CDNF Antibody: ARMETL1, ARMETL1, Cerebral dopamine neurotrophic factor, ARMET-like protein 1

Immunogen :

CDNF antibody was raised against a 9 amino acid synthetic peptide from near the carboxy terminus of human CDNF.

Specificity :

This antibody does not cross-react with MANF.

Purity :

CDNF Antibody is affinity chromatography purified via peptide column.

Buffer :

CDNF Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration :

1 mg/mL

Uses :

E, WB, IHC, IF

Application Summary :

CDNF antibody can be used for detection of CDNF by Western blot at 2 - 4 g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 g/mL. For immunofluorescence start at 20 g/mL.

Storage :

CDNF antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Lindholm P, Voutilainen MH, Lauren J, et al. Novel neurotrophic factor CDNF protects and rescues midbrain dopamine neurons in vivo. Nature2007; 448:73-7.

General References :

Petrova P, Raibekas A, Pevsner J, et al. MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. J. Mol. Neurosci.2003; 20:173-88.

more info or order :

ProSci product webpage