KIF5 Antibody | ProSci 4289 product information

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product summary

company name :

ProSci

product type :

antibody

product name :

KIF5 Antibody

catalog :

4289

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry

product information

Catalog Number :

4289

Product Name :

KIF5 Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human, Mouse, Rat

Background :

KIF5 Antibody: The kinesin superfamily proteins (KIFs) are microtubule-dependent motors that slide along microtubules and transport cellular organelles and mRNA to different parts of the cell. In neurons, KIF5 performs this role in an anterograde fashion from the neuronal cell body to axonal or dendritic terminals. KIF5 was initially differentiated from the ubiquitously expressed kinesin as being highly enriched in subsets of neurons and selectively concentrated in the cell body. KIF5 has at least three known isoforms; this antibody recognizes all three. Mutations in one of the isoforms of KIF5 (KIF5A) are thought to be involved in hereditary spastic paraplegias.

ALTnames :

KIF5 Antibody: NKHC, MY050, SPG10, D12S1889, NKHC1, Kinesin heavy chain isoform 5A, Kinesin heavy chain neuron-specific 1, NKHC

Immunogen :

KIF5 antibody was raised against a 20 amino acid synthetic peptide from near the carboxy terminus of human KIF5.

Purity :

KIF5 Antibody is affinity chromatography purified via peptide column.

Buffer :

KIF5 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration :

1 mg/mL

Uses :

E, WB, ICC, IF

Application Summary :

KIF5 antibody can be used for detection of KIF5 by Western blot at 0.5 - 1 g/mL. Antibody can also be used for immunocytochemistry starting at 5 g/mL. For immunofluorescence start at 20 g/mL.

Storage :

KIF5 antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Hirokawa N. mRNA transport in dendrites: RNA granules, motors and tracks. J. Neurosci.2006; 26:7139-42.

General References :

Niclas J, Navone F, Hom-Booher N, et al. Cloning and localization of a conventional KIF5 motor expressed exclusively in neurons. Neuron1994; 12:1059-72.

General References :

Fichera M, Lo Giudice M, Falco M, et al. Evidence of kinesin heavy chain (KIF5A) involvement in pure hereditary spastic paraplegia. Neurology2004; 63:1108-10.