BAFF Receptor Antibody | ProSci 3097 product information

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product summary

company name :

ProSci

product type :

antibody

product name :

BAFF Receptor Antibody

catalog :

3097

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry

product information

Catalog Number :

3097

Product Name :

BAFF Receptor Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human, Mouse, Rat

Background :

BAFF Receptor Antibody: Members in the TNF superfamily regulate immune responses and induce apoptosis. A novel member in the TNF family was recently identified by several groups and designated BAFF, BLyS, TALL-1, THANK, and zTNF4. BAFF/BLyS was characterized as a B cell activator since it induced B cell proliferation and immunoglobulin secretion. Two receptors, TACI and BCMA, for BAFF were originally identified. A third receptor was identified recently and designated BAFF-R and BR3 for BLyS receptor 3. Unlike BCMA and TACI, which bind to BAFF and April, BAFF-R/BR3 is specific for BAFF and plays a predominant role in BAFF induced B cell development and survival. BAFF and its receptors are involved in B cell associated autoimmune diseases, and activate NF- B and c-jun N-terminal kinase.

ALTnames :

BAFF Receptor Antibody: BAFFR, CD268, CVID4, BAFF-R, BROMIX, prolixin, BAFFR, BR3, Tumor necrosis factor receptor superfamily member 13C, B-cell-activating factor receptor

Immunogen :

BAFF Receptor antibody was raised against a synthetic peptide corresponding to 15 amino acids near the carboxy terminus of human BAFF Receptor The peptide sequence is identical between human and mouse origin.

Purity :

BAFF Receptor Antibody is affinity chromatography purified via peptide column.

Buffer :

BAFF Receptor Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration :

1 mg/mL

Uses :

E, WB, IHC

Application Summary :

BAFF Receptor antibody can be used for detection of BAFF Rexeptor by Western blot at 5 g/mL. Antibody can also be used for immunohistochemistry starting at 5 g/mL.

Storage :

BAFF Receptor antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Moore PA, Belvedere O, Orr A, et al. BLyS: member of the tumor necrosis factor family and B lymphocyte stimulator. Science 1999;285:260-3

General References :

Schneider P, MacKay F, Steiner V, et al. BAFF, a novel ligand of the tumor necrosis factor family, stimulates B cell growth. J Exp Med 1999;189:1747-56

General References :

Shu HB, Hu WH, Johnson H. TALL-1 is a novel member of the TNF family that is down-regulated by mitogens. J Leukoc Biol 1999;65:680-3

General References :

Mukhopadhyay A, Ni J, Zhai Y, Yu GL, Aggarwal BB. Identification and characterization of a novel cytokine, THANK, a TNF homologue that activates apoptosis, nuclear factor- B, and c-Jun NH2-terminal kinase. J Biol Chem 1999 ;274:15978-81