ARTS Antibody | ProSci 3025 product information

product summary

company name :

ProSci

product type :

antibody

product name :

ARTS Antibody

catalog :

3025

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

African green monkey, human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

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citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; mouse western blot; African green monkey	Bornstein B, Gottfried Y, Edison N, Shekhtman A, Lev T, Glaser F, et al. ARTS binds to a distinct domain in XIAP-BIR3 and promotes apoptosis by a mechanism that is different from other IAP-antagonists. Apoptosis. 2011;16:869-81 pubmed publisher

product information

Catalog Number :

3025

Product Name :

ARTS Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human

Background :

ARTS Antibody: Apoptosis is related to many diseases and development. Mitochondrial proteins, such as cytochrome c, Apaf-1, and AIF play important role in apoptosis. A novel mitochondrial septin-like protein was identified recently and designated ARTS for apoptosis related protein in TGF-beta signaling pathway. ARTS that is encoded by the human septin H5/PNUTL2/CDCrel2b gene is located to mitochondria and translocates to the nucleus when apoptosis occurs. ARTS is expressed in many tissues. It enhances cell death induced by TGF-beta and, to a lesser extent, by other apoptotic agents, such as TNF- and Fas ligand.

ALTnames :

ARTS Antibody: H5, ARTS, MART, SEP4, CE5B3, PNUTL2, hucep-7, BRADEION, hCDCREL-2, Septin-4, Apoptosis-related protein in the TGF-beta signaling pathway

Immunogen :

ARTS antibody was raised against a synthetic peptide corresponding to amino acids near the amino terminus of human ARTS.

Purity :

ARTS Antibody is affinity chromatography purified via peptide column.

Buffer :

ARTS Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration :

1 mg/mL

Uses :

E, WB, IHC, IF

Application Summary :

ARTS antibody can be used for detection of ARTS by Western blot at 2 g/mL. A band at 32 kDa can be detected. Antibody can also be used for immunohistochemistry starting at 2 g/mL. For immunofluorescence start at 20 g/mL.

Storage :

ARTS antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Larisch S, Yi Y, Lotan R, Kerner H, et al. A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif. Nat Cell Biol 2000;2(12):915-21

General References :

Depraetere V. The ARTS of apoptosis. Nat Cell Biol. 2000;2(12):E219.

General References :

Paavola,P., Horelli-Kuitunen,N., Palotie,A. and Peltonen,L. Characterization of a novel gene, PNUTL2, on human chromosome 17q22-q23 and its exclusion as the Meckel syndrome gene. Genomics 1999;55 (1):122-125

General References :

Zieger,B., Tran,H., Hainmann, I. , Wunderle,D., Zgaga-Griesz,A., Blaser,S. and Ware,J. Characterization and expression analysis of two human septin genes, PNUTL1 and PNUTL2. Gene 2000;261(2):197-203

more info or order :

ProSci product webpage