TP1 Antibody | ProSci 2345 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProSci

product type :

antibody

product name :

TP1 Antibody

catalog :

2345

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry

product information

Catalog Number :

2345

Product Name :

TP1 Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human, Mouse, Rat

Background :

TP1 Antibody: Telomerase is an RNA-dependent DNA polymerase that uses an RNA component to add telomeric repeat sequences at the ends of chromosomes. Besides the RNA component which serves as the template that specifies the telomeric repeat, the telomerase complex contains a reverse transcriptase protein (TRT) and various accessory proteins including the telomerase-associated protein 1 (TP1). Telomerase activity is low in most somatic cells, causing the gradual shortening of telomeres which can ultimately lead to telomere fusion and cell death. High levels of telomerase activity are widely seen in cancerous cells and while recent experiments have suggested that telomerase may be a viable target in cancer therapy, expression levels of TP1 do not correlate with malignancy. At least two isoforms of TP1 are known to exist.

ALTnames :

TP1 Antibody: TP1, TLP1, p240, TROVE1, VAULT2, TP1, Telomerase protein component 1, Telomerase-associated protein 1, Telomerase protein 1

Immunogen :

TP1 antibody was raised against a 20 amino acid synthetic peptide from near the amino terminus of human TP1.

Purity :

TP1 Antibody is affinity chromatography purified via peptide column.

Buffer :

TP1 Antibody is supplied in PBS containing 0.02% sodium azide.

Uses :

E, WB, IHC, IF

Application Summary :

TP1 antibody can be used for detection of TP1 by Western blot at 1 - 2 g/mL. Antibody can also be used for immunohistochemistry starting at 2.5 g/mL. For immunofluorescence start at 20 g/mL.

Storage :

TP1 antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Greider CW. Telomere length regulation. Annu. Rev. Biochem.1996; 274:92-7.

General References :

Cong YS, Wright WE, and Shay JW. Human telomerase and its regulation. Microbiol. Mol. Biol. Rev.2002; 66:407-25.

General References :

Harrington L, McPhail T, Mar V, et al. A mammalian telomerase-associated protein. Science1997; 275:973-7.

General References :

Wong JMY and Collins K. Telomere maintenance and disease. Lancet2003; 362:983-8.