IKK gamma Antibody | ProSci 2335 product information

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product summary

company name :

ProSci

product type :

antibody

product name :

IKK gamma Antibody

catalog :

2335

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry

product information

Catalog Number :

2335

Product Name :

IKK gamma Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human, Mouse, Rat

Background :

IKK gamma Antibody: Nuclear factor kappa B (NF- B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF- B mediates the expression of a great variety of genes in response to extracellular stimuli. NF- B is associated with I B proteins in the cell cytoplasm, which inhibit NF- B activity. The I B kinase (IKK and IKK ) phosphorylates IkB and mediates NF- B activation. A novel molecule in the IKK complex was recently identified and termed IKK /NEMO/FIP3/IKKAP1. IKK interacts with IKK and is required for the activation of IKK complex and NF- B by LPS, PMA, TNF, and IL-1 stimulation. FIP3 was also shown to bind to RIP and NIK and to mediate TNF-induced NF- B activation.

ALTnames :

IKK gamma Antibody: IP, IP1, IP2, FIP3, IPD2, NEMO, FIP-3, Fip3p, AMCBX1, ZC2HC9, IKK-gamma, NF-kappa-B essential modulator

Immunogen :

IKK gamma antibody was raised against a 17 amino acid peptide near the carboxy terminus of human IKK gamma.

Specificity :

IKK gamma has no cross response to IKK alpha or IKK beta.

Purity :

IKK gamma Antibody is affinity chromatography purified via peptide column.

Buffer :

IKK gamma Antibody is supplied in PBS containing 0.02% sodium azide.

Uses :

E, WB, ICC

Application Summary :

IKK gamma antibody can be used for detection of IKK gamma by Western blot at 1 g/mL. A 52 kDa band should be detected. Antibody can also be used for immunocytochemistry starting at 5 g/mL.

Storage :

IKK gamma antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Rothwarf DM, Zandi E, Natoli G, Karin M. IKK- is an essential regulatory subunit of the I B kinase complex. Nature 1998;395(6699):297-300

General References :

Yamaoka S, Courtois G, Bessia C, Whiteside ST, Weil R, Agou F, Kirk HE, Kay RJ, Israel A. Complementation cloning of NEMO, a component of the I B kinase complex essential for NF- B activation. Cell. 1998;93(7):1231-40.

General References :

Li Y, Kang J, Friedman J, Tarassishin L, Ye J, Kovalenko A, Wallach D, Horwitz MS. Identification of a cell protein (FIP-3) as a modulator of NF- B activity and as a target of an adenovirus inhibitor of tumor necrosis factor -induced apoptosis. Proc Natl Acad Sci U S A 1999;96(3):1042-7

General References :

Mercurio F, Murray BW, Shevchenko A, Bennett BL, Young DB, Li JW, Pascual G, Motiwala A, Zhu H, Mann M, Manning AM. I B kinase (IKK)-associated protein 1, a common component of the heterogeneous IKK complex. Mol Cell Biol. 1999;19(2):1526-38.