IKK epsilon Antibody | ProSci 2329 product information

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product summary

company name :

ProSci

product type :

antibody

product name :

IKK epsilon Antibody

catalog :

2329

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunohistochemistry

product information

Catalog Number :

2329

Product Name :

IKK epsilon Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human

Background :

IKK epsilon Antibody: Nuclear factor kappa B (NF- B) is a ubiquitous transcription factor and an essential mediator of gene expression during activation of immune and inflammatory responses. NF- B mediates the expression of a great variety of genes in response to extracellular stimuli. NF- B is associated with I B proteins in the cell cytoplasm, which inhibit NF- B activity. I B is phosphorylated by I B kinase (IKK) complex that contains IKK , IKK , and IKK . A novel molecule in the IKK complex was recently identified and designated IKK /IKK-i. IKK epsilon is required for the activation of NF- B by PMA and T cell receptors but not by TNF and IL-1. IKK /IKK-i message is expressed in a variety of tissues and is inducible by TNF , IL-1, and LPS.

ALTnames :

IKK epsilon Antibody: IKKE, IKKI, IKK-E, IKK-i, IKKE, KIAA0151, Inhibitor of nuclear factor kappa-B kinase subunit epsilon, Inducible I kappa-B kinase, I-kappa-B kinase epsilon

Immunogen :

IKK epsilon antibody was raised against a 16 amino acid peptide near the carboxy terminus of human IKK epsilon.

Specificity :

It has no cross response to IKKa, IKKb, or IKKy.

Purity :

IKK epsilon Antibody is affinity chromatography purified via peptide column.

Buffer :

IKK epsilon Antibody is supplied in PBS containing 0.02% sodium azide.

Uses :

E, WB, IHC

Application Summary :

IKK epsilon antibody can be used for detection of IKK epsilon by Western blot at 1 g/mL. An 80 kDa band should be detected. Antibody can also be used for immunohistochemistry starting at 10 g/mL.

Storage :

IKK epsilon antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Peters RT, Liao SM, Maniatis T. IKK epsilonpsilon is part of a novel PMA-inducible I B kinase complex. Mol Cell 2000;5(3):513-22

General References :

Shimada T, Kawai T, Takeda K, Matsumoto M, Inoue J, Tatsumi Y, Kanamaru A, Akira S. IKK-i, a novel lipopolysaccharide-inducible kinase that is related to I B kinases. Int Immunol 1999;11(8):1357-62 (WD0101)