antibody

FAIM2 Antibody

2285

0.02 mg, 0.1 mg

79, 315 USD

polyclonal

rabbit

nonconjugated

human, mouse, rat

western blot, ELISA, immunohistochemistry

FAIM2 Antibody

Rabbit

Polyclonal

Unconjugated

Primary Antibody

0.02 mg, 0.1 mg

79, 315 USD

IgG

Human, Mouse, Rat

FAIM2 Antibody: Programmed cell death regulates a number of biological processes such as normal organism development, tissue homeostasis, and removal of damaged cells. Disruption of this process has been implicated in a variety of diseases such as cancer. FAIM2 is a recently identified protein that can inhibit the apoptotic signal transduced by the Fas receptor but not from the related tumor necrosis factor-alpha death signal. In this respect, FAIM2 is functionally similar to the anti-apoptotic proteins FAIM, FLIP and Bcl-xL. FAIM2, a seven membrane spanning protein, can bind the Fas receptor but does not regulate Fas expression or inhibit binding of FADD to Fas. FAIM2 is widely distributed, but highly expressed in the hippocampus and other neural tissues. FAIM2 was also identified as the neural membrane protein 35 (NMP35) and its expression is known to be regulated by the Phosphatidylinositol 3-kinase-Akt/PKB pathway.

FAIM2 Antibody: LFG, LFG2, NGP35, NMP35, TMBIM2, KIAA0950, LFG, Protein lifeguard 2, Fas apoptotic inhibitory molecule 2

FAIM2 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human FAIM2.

FAIM2 Antibody is affinity chromatography purified via peptide column.

FAIM2 Antibody is supplied in PBS containing 0.02% sodium azide.

E, WB, IHC

FAIM2 antibody can be used for detection of FAIM2 by Western blot at 0.5 - 1 g/mL. Antibody can also be used for immunohistochemistry starting at 5 g/mL.

FAIM2 antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Lockshin RA, Osborne B, and Zakeri Z. Cell death in the third millennium. Cell Death Differ. 2000; 7:2-7.

Somia NV, Schmitt MJ, Vetter DE, et al. FAIM2: an anti-apoptotic gene that provides protection from Fas-mediated cell death. Proc. Natl. Acad. Sci. USA 1999; 96:12667-72.

Schneider TJ, Fischer GM, Donohoe TJ, et al. A novel gene coding for a Fas apoptosis inhibitory molecule (FAIM) isolated from inducibly Fas-resistant B lymphocytes. J. Exp. Med. 1999; 189:949-55.

Schweitzer B, Taylor V, Welcher AA, et al. Neural membrane protein 35 (NMP35): a novel member of a gene family which is highly expressed in the adult nervous system. Mol. Cell. Neurosci. 1998; 11:260-73.