SODD Antibody | ProSci 2143 product information

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product summary

company name :

ProSci

product type :

antibody

product name :

SODD Antibody

catalog :

2143

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry

product information

Catalog Number :

2143

Product Name :

SODD Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human, Mouse, Rat

Background :

SODD Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand of the TNF family through their death domain containing receptors, TNF-R1 and Fas. Several novel death receptors including DR3, DR4, DR5, and DR6 were recently identified. Cell death signal is transduced by death domain containing adapter molecules through the interaction with death domain of these death receptors. A novel TNF-R1 interacting protein was recently identified and designated SODD for silencer of death domains. SODD associates with the death domain of TNF-R1 and prevents constitutive activation of TNF-R1 signaling. TNF treatment releases SODD and permits adapter molecules such as TRADD recruiting to the active TNF-R1 complex, which activates TNF signaling pathways. SODD also interacts with DR3. SODD is ubiquitously expressed in human tissues and cell lines.

ALTnames :

SODD Antibody: SODD, BAG-4, SODD, BAG family molecular chaperone regulator 4, Bcl-2-associated athanogene 4

Immunogen :

SODD antibody was raised against a peptide corresponding to amino acids near the amino terminus of human SODD.

Purity :

SODD Antibody is Antibody is DEAE purified.

Buffer :

SODD Antibody is supplied in PBS containing 0.02% sodium azide.

Uses :

E, WB, ICC, IF

Application Summary :

SODD antibody can be used for detection of SODD by Western blot at 0.5 g/mL. An approximately 60 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 5 g/mL. For immunofluorescence start at 20 g/mL.

Storage :

SODD antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Jiang Y, Woronicz JD, Liu W, Goeddel DY. Prevention of constitutive TNF receptor 1 signaling by silencer of death domains. Science 1999;283:543-6 (RD1299)