This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
ProSci
product type :
antibody
product name :
APP Antibody
catalog :
2136
quantity :
0.02 mg, 0.1 mg
price :
79, 315 USD
clonality :
polyclonal
host :
rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry
product information
Catalog Number :
2136
Product Name :
APP Antibody
Host Species :
Rabbit
Clonality :
Polyclonal
Conjugation :
Unconjugated
Product Type :
Primary Antibody
Size :
0.02 mg, 0.1 mg
List Price :
79, 315 USD
Isotype :
IgG
CrossReactivity :
Human, Mouse, Rat
Background :
APP Antibody: Accumulation of the amyloid-beta peptide (Abeta) in the cerebral cortex is a critical event in the pathogenesis of Alzheimer's disease. The beta-amyloid protein precursor (APP) is cleaved by beta-secretase, producing a soluble derivative of the protein and a membrane anchored 99-amino acid carboxy-terminal fragment (C99). The C99 fragment serves as substrate for gamma-secretase to generate the 4 kDa amyloid-beta peptide (Abeta), which is deposited in the brains of all suffers of Alzheimer's disease.
ALTnames :
APP Antibody: AAA, AD1, PN2, ABPP, APPI, CVAP, ABETA, PN-II, CTFgamma, A4, Amyloid beta A4 protein, APP
Immunogen :
APP antibody was raised against a 15 amino acid peptide near the carboxy terminus of human APP.
Purity :
APP Antibody is affinity chromatography purified via peptide column.
Buffer :
APP Antibody is supplied in PBS containing 0.02% sodium azide.
Uses :
E, WB, IHC, IF
Application Summary :
APP antibody can be used for detection of APP and the C99 fragment by Western blot at 2 g/mL. Antibody can also be used for immunohistochemistry starting at 2 g/mL. For immunofluorescence start at 20 g/mL.
Storage :
APP antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
General References :
Ponte P, Gonzalez-DeWhitt P, Schilling J, Miller J, Hsu D, Greenberg B, Davis K, Wallace W, Lieberburg I, Fuller F. A new A4 amyloid mRNA contains a domain homologous to serine proteinase inhibitors. Nature 1988;331:525-7
General References :
Selkoe D.J. Cell biology of the amyloid -protein precursor and the mechanism of Alzheimer's disease.Annu Rev Cell Biol 1994;10:373-403 (RD1299)
company information
ProSci
12170 Flint Place
Poway, CA 92064
orders@prosci-inc.com
www.prosci-inc.com
1-888-513-9525
headquarters: USA