IL-1RAcP Antibody | ProSci 2131 product information

product summary

company name :

ProSci

product type :

antibody

product name :

IL-1RAcP Antibody

catalog :

2131

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunocytochemistry

more info or order :

ProSci product webpage

citations: 2

Reference
Millar N, Gilchrist D, Akbar M, Reilly J, Kerr S, Campbell A, et al. MicroRNA29a regulates IL-33-mediated tissue remodelling in tendon disease. Nat Commun. 2015;6:6774 pubmed publisher
Mukherjee J, Phillips J, Zheng S, Wiencke J, Ronen S, Pieper R. Pyruvate kinase M2 expression, but not pyruvate kinase activity, is up-regulated in a grade-specific manner in human glioma. PLoS ONE. 2013;8:e57610 pubmed publisher

product information

Catalog Number :

2131

Product Name :

IL-1RAcP Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human

Background :

IL-1RAcP Antibody: The pro-inflammatory cytokine IL-1 induced cellular response requires two subunits of its receptor, IL-1 receptor I(IL-1RI) and IL-1 receptor accessory protein (IL-1RAcP). IL-1 RAcP forms a complex with IL-1RI in response to IL-1 treatment. The IL-1 receptor-associated kinase (IRAK), which mediates activation of NF- B inducing kinae (NIK) and of NF- B, recruites to the IL-1R complex through IL-1 RAcP. IL-1 activation of stress-activated protein kinase and of acid sphingomyelinase also requires IL-1RAcP. Like IL-1RI, IL-1RAcP subunit is essential for IL-1 mediated cellular response. IL-1RAcP is expressed in many tissues.

ALTnames :

IL-1RAcP Antibody: IL1R3, C3orf13, IL-1RAcP, IL1R3, Interleukin-1 receptor accessory protein, Interleukin-1 receptor 3, IL-1 receptor accessory protein

Immunogen :

IL-1RAcP antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of IL-1RAcP, which differs from. The sequence of mouse origin by three amino acids.

Specificity :

It has no cross activity to other member in the IL-1 receptor family.

Purity :

IL-1RAcP Antibody is affinity chromatography purified via peptide column.

Buffer :

IL-1RAcP Antibody is supplied in PBS containing 0.02% sodium azide.

Uses :

E, WB, ICC

Application Summary :

IL-1RAcP antibody can be used for detection of IL-1RAcP by Western blot 0.5 g/mL. An approximately 66 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 5 g/mL.

Storage :

IL-1RAcP antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Greenfeder SA, Nunes P, Kwee L, Labow M, Chizzonite RA, Ju G. Molecular cloning and characterization of a second subunit of the interleukin 1 receptor complex. J Biol Chem 1995;270:13757-65

General References :

Huang J, Gao X, Li S, Cao Z. Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein. Proc Natl Acad Sci U S A 1997;94:12829-32

General References :

Wesche H, Korherr C, Kracht M, Falk W, Resch K, Martin MU. The interleukin-1 receptor accessory protein (IL-1RAcP) is essential for IL-1-induced activation of interleukin-1 receptor-associated kinase (IRAK) and stress-activated protein kinases (SAP kinases). J Biol Chem 1997;272:7727-31

General References :

Hofmeister R, Wiegmann K, Korherr C, Bernardo K, Kronke M, Falk W. Activation of acid sphingomyelinase by interleukin-1 (IL-1) requires the IL-1 receptor accessory protein. J Biol Chem 1997;272:27730-6 (RD1299)

more info or order :

ProSci product webpage