DcR2 Antibody | ProSci 2021 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProSci

product type :

antibody

product name :

DcR2 Antibody

catalog :

2021

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, ELISA, immunocytochemistry

product information

Catalog Number :

2021

Product Name :

DcR2 Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human, Mouse, Rat

Background :

DcR2 Antibody: Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors. TRAIL/Apo2L is a new member of the TNF family and induces apoptosis of a variety of tumor cell lines. DR4 and DR5 are the recently identified functional receptors for TRAIL, and DcR1/TRID is a decoy receptor. Another member of the TRAIL receptor family was more recently identified and designated DcR2, TRAIL-R4, or TRUNDD. DcR2 has an extracellular TRAIL-binding domain but lacks intracellular death domain and does not induce apoptosis. Like DR4 and DR5, DcR2 transcript is widely expressed in normal human tissues. Overexpression of DcR2 attenuated TRAIL-induced apoptosis.

ALTnames :

DcR2 Antibody: DCR2, CD264, TRUNDD, TRAILR4, TRAIL-R4, DCR2, UNQ251/PRO288, Tumor necrosis factor receptor superfamily member 10D, Decoy receptor 2, DcR2

Immunogen :

DcR2 antibody was raised against a 15 amino acid peptide near the center of human DcR2.

Purity :

DcR2 Antibody is affinity chromatography purified via peptide column.

Buffer :

DcR2 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration :

1 mg/mL

Uses :

E, WB, ICC

Application Summary :

DcR2 antibody can be used for detection of DcR2 expression by Western blot at 1 g/mL. Antibody can also be used for immunocytochemistry starting at 10 g/mL.

Storage :

DcR2 antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Pan G, O'Rourke K, Chinnaiyan AM, et al. The receptor for the cytotoxic ligand TRAIL. Science 1997; 276:111-3.

General References :

Pan G, Ni J, Wei YF, Yu G, et al. An antagonist decoy receptor and a death domain-containing receptor for TRAIL. Science 1997; 277:815-8.

General References :

Sheridan JP, Marsters SA, Pitti RM, et al. Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors. Science 1997; 277:818-21.

General References :

Marsters SA, Sheridan JP, Pitti RM, et al. A novel receptor for Apo2L/TRAIL contains a truncated death domain. Curr. Biol. 1997; 7:1003-6.