SIRP alpha Antibody | ProSci 1125 product information

product summary

company name :

ProSci

product type :

antibody

product name :

SIRP alpha Antibody

catalog :

1125

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry

more info or order :

ProSci product webpage

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; loading ...; fig 2b	Shirakabe K, Omura T, Shibagaki Y, Mihara E, Homma K, Kato Y, et al. Mechanistic insights into ectodomain shedding: susceptibility of CADM1 adhesion molecule is determined by alternative splicing and O-glycosylation. Sci Rep. 2017;7:46174 pubmed publisher

product information

Catalog Number :

1125

Product Name :

SIRP alpha Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human, Mouse, Rat

Background :

SIRP alpha Antibody: Protein tyrosine phosphatases (PTPases) SHP-1 and SHP-2 are critical regulators in the intracellular signaling pathways that result in cell responses such as mitosis, differentiation, migration, survival, transformation or death. SHP-2 is a signal transducer for several receptor tyrosine kinases and cytokine receptors. A novel SHP-2 associated glycoprotein was recently cloned from human, rat, mouse and cattle by several labs and was designated SIRPalpha, SHPS-1, MyD-1, BIT and p84. SIRPalpha is a new gene family containing at least fifteen members. SIRPalpha is a substrate of many activated tyrosine kinases such as insulin receptor, EGFR, PDGFR and src, and a specific docking protein for SHP-2. SIRPalpha has regulatory effects on cellular responses induced by serum, growth factors, insulin, oncogenes, growth hormones and cell adhesion and plays a general role in different physiological and pathological processes.

ALTnames :

SIRP alpha Antibody: BIT, MFR, P84, SIRP, MYD-1, SHPS1, CD172A, PTPNS1, BIT, MYD1, Tyrosine-protein phosphatase non-receptor type substrate 1, Brain Ig-like molecule with tyrosine-based activation motifs, SHP substrate 1

Immunogen :

SIRP alpha antibody was raised against a peptide corresponding to 17 amino acids near the carboxy terminus of human SIRP alpha 1.

Specificity :

Recognizes SIRP alpha 1, 2 and 3.

Purity :

SIRP alpha Antibody is affinity chromatography purified via peptide column.

Buffer :

SIRP alpha Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration :

1 mg/mL

Uses :

E, WB, ICC

Application Summary :

SIRP alpha antibody can be used for Western blot at 0.5 - 1 g/mL. 75 - 110 kDa bands should be detected. Antibody can also be used for immunocytochemistry starting at 1 g/mL.

Storage :

SIRP alpha antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Kharitonenkov A, et al. Nature 1997;386:181-186.

General References :

Fujioka Y, et al. Mol Cell Biol 1996;16:6887-6899

General References :

Yamao T, et al. Biochem Biophys Res Commun 1997;231:61-67

General References :

Brooke GP, et al. Eur J Immunol 1998;28:1-11

more info or order :

ProSci product webpage