STAT1 alpha Antibody | ProSci 1021 product information

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product summary

company name :

ProSci

product type :

antibody

product name :

STAT1 alpha Antibody

catalog :

1021

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation

product information

Catalog Number :

1021

Product Name :

STAT1 alpha Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human, Mouse, Rat

Background :

STAT1 alpha Antibody: STATs (signal transducers and activators of transcription) are a family of cytoplasmic latent transcription factors that are activated to regulate gene expression in response to a large number of extracellular signaling polypeptides including cytokines, interferons, and growth factors. After phosphorylation by JAK tyrosine kinases, STATs enter the nucleus to regulate transcription of many different genes. Among the seven STATs (Stat1, Stat2, Stat3, Stat4, Stat5a, Stat5b, and Stat6), Stat1, Stat3, Stat5a, and Stat5b have a wide activation profile. STAT1 is activated by many different ligands including IFN family (IFN- , IFN- , IFN- and IL-10), gp130 family (IL-6, IL-11, LIF, CNTF, and G-CSF), and receptor tyrosine kinases (EGF, PDGF, and CSF-1). STAT1 has two forms, the 91 kDa STAT1 and the 84 kDa STAT1 which are encoded by the same gene with splicing variant.

ALTnames :

STAT1 alpha Antibody: CANDF7, ISGF-3, STAT91

Immunogen :

STAT1 antibody was raised against a peptide corresponding to amino acids near the carboxy terminus of human STAT1 alpha. The sequences differ from the murine corresponding sequences by four amino acids.

Specificity :

No reaction to the 84 kDa STAT1a.

Purity :

STAT1 alpha Antibody is Antibody is DEAE purified.

Buffer :

STAT1 alpha Antibody is supplied in PBS containing 0.02% sodium azide.

Uses :

E, WB, ICC, IP

Application Summary :

STAT1 alpha antibody can be used for Western blot at 1:1000 to 1:2000 and for immunoprecipitation at 2 to 4 g per sample. A 91 kDa band can be detected. Antibody can also be used for immunocytochemistry starting at 10 g/mL.

Storage :

STAT1 alpha antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Leonard WJ, O'Shea JJ. Jaks and STATs: biological implications. Annu Rev Immunol 1998;16:293-322

General References :

Schindler C, Darnell JE Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem 1995;64:621-51

General References :

Darnell JE Jr. STATs and gene regulation. Science 1997;277:1630-5

General References :

Schindler C, Fu XY, Improta T, Aebersold R, Darnell JE Jr. Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon . Proc Natl Acad Sci USA 1992;89:7836 (RD1299)