CXCR4 Antibody | ProSci 1009 product information

product summary

company name :

ProSci

product type :

antibody

product name :

CXCR4 Antibody

catalog :

1009

quantity :

0.02 mg, 0.1 mg

price :

79, 315 USD

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, ELISA, immunocytochemistry, immunoprecipitation, FACS

more info or order :

ProSci product webpage

citations: 1

Reference
Dash P, Siddappa N, Mangaiarkarasi A, Mahendarkar A, Roshan P, Anand K, et al. Exceptional molecular and coreceptor-requirement properties of molecular clones isolated from an Human Immunodeficiency Virus Type-1 subtype C infection. Retrovirology. 2008;5:25 pubmed publisher

product information

Catalog Number :

1009

Product Name :

CXCR4 Antibody

Host Species :

Rabbit

Clonality :

Polyclonal

Conjugation :

Unconjugated

Product Type :

Primary Antibody

Size :

0.02 mg, 0.1 mg

List Price :

79, 315 USD

Isotype :

IgG

CrossReactivity :

Human, Mouse

Background :

CXCR4 Antibody: Human immunodeficiency virus (HIV) and related viruses require coreceptors, in addition to CD4, to infect target cells. Some G protein-coupled receptors including CCR5, CXCR4, CCR3, CCR2b and CCR8 in the chemokine receptor family, and four new human molecules GPR15, STRL33, GPR1 and V28 were recently identified as HIV coreceptors. Among them, CXCR4 (fusin, LESTR or HUMSTR) is a principal coreceptor for T-cell tropic strains of HIV-1 fusion and entry of human white blood cells. CXCR4 is also required for the infection by dual-tropic strains of HIV-1 and mediates CD-4 independent infection by HIV-2. The a-chemokine SDF-1 is the ligand for CXCR4 and prevents infection by T-tropic HIV-1. CXCR4 associates with the surface CD4-gp120 complex before HIV enters target cells. CXCR4 messenger RNA levels correlated with HIV-1 permissiveness in diverse human cell types. Antibodies to CXCR4 block HIV-1 and HIV-2 fusion and infection of human target cells. The amino-terminal domain and the second extracellular loop of CXCR4 serve as HIV binding sites.

ALTnames :

CXCR4 Antibody: FB22, HM89, LAP3, LCR1, NPYR, WHIM, CD184, LESTR, NPY3R, NPYRL, HSY3RR, NPYY3R, D2S201E

Immunogen :

CXCR4 antibody was raised against a peptide corresponding to 14 amino acids near the amino terminus of human CXCR4.

Specificity :

CXCR4 Antibody is predicted to not cross-react with other CXCR familiy members.

Purity :

CXCR4 Antibody is affinity chromatography purified via peptide column.

Buffer :

CXCR4 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration :

1 mg/mL

Uses :

E, WB, ICC, IP, IF, FACS

Application Summary :

CXCR4 antibody can be used for Western blot at 1 - 2 g/mL dilution and for immunoprecipitation and immunocytochemistry at 10 g/mL. Immunofluorescence starting at 20 g/mL. Flow Cytometry at 0.1 g/ml

Storage :

CXCR4 antibody can be stored at 4 C for three months and -20 C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

General References :

Dimitrov DS. Cell 1997;91:721-730

General References :

Feng Y et al. Science 1996;272:872-7

General References :

Berson JF et al. J Virol 1996;70:6288-95

General References :

Doranz BJ et al. Cell 1996;85:1149-1158

more info or order :

ProSci product webpage