Mouse Monoclonal Antibody to SMAD1 | ProMab 31030 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to SMAD1

catalog :

31030

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

4E12H10

The same clone is also sold as:

Invitrogen: MA5-38633
Novus Biologicals: NBP2-61878

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry

product information

Catalog :

31030

Title :

Mouse Monoclonal Antibody to SMAD1

Species :

Human; Mouse; Monkey;

Clone :

4E12H10;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signals of the bone morphogenetic proteins (BMPs), which are involved in a range of biological activities including cell growth, apoptosis, morphogenesis, development and immune responses. In response to BMP ligands, this protein can be phosphorylated and activated by the BMP receptor kinase. The phosphorylated form of this protein forms a complex with SMAD4, which is important for its function in the transcription regulation. This protein is a target for SMAD-specific E3 ubiquitin ligases, such as SMURF1 and SMURF2, and undergoes ubiquitination and proteasome-mediated degradation. Alternatively spliced transcript variants encoding the same protein have been observed.;

Immunogen :

Purified recombinant fragment of human SMAD1 (AA: 1-110) expressed in E. Coli.

Formulation :

Purified antibody in PBS with 0.05% sodium azide

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: ; ICC: ; FCM:

References :

1.Histol Histopathol. 2011 Apr;26(4):531-41. ; 2.Blood. 2011 Jun 16;117(24):6489-97.;

Type :

Monoclonal Antibody

MW :

52kDa

Aliases :

BSP1; JV41; BSP-1; JV4-1; MADH1; MADR1