antibody

Mouse Monoclonal Antibody to CD274

31027

0.1 mg

monoclonal

mouse

nonconjugated

7D2A10

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry

Mouse Monoclonal Antibody to CD274

Human;

7D2A10;

Mouse IgG2b

0.1 mg

4℃; -20℃ for long term storage

This gene encodes an immune inhibitory receptor ligand that is expressed by hematopoietic and non-hematopoietic cells, such as T cells and B cells and various types of tumor cells. The encoded protein is a type I transmembrane protein that has immunoglobulin V-like and C-like domains. Interaction of this ligand with its receptor inhibits T-cell activation and cytokine production. During infection or inflammation of normal tissue, this interaction is important for preventing autoimmunity by maintaining homeostasis of the immune response. In tumor microenvironments, this interaction provides an immune escape for tumor cells through cytotoxic T-cell inactivation. Expression of this gene in tumor cells is considered to be prognostic in many types of human malignancies, including colon cancer and renal cell carcinoma. Alternative splicing results in multiple transcript variants.;

Purified recombinant fragment of human CD274 (AA: 24-153) expressed in E. Coli.

Purified antibody in PBS with 0.05% sodium azide

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: ; ICC: ; FCM: 1/200 - 1/400

1.Anticancer Res. 2015 Oct;35(10):5369-76. ; 2.Lung Cancer. 2015 Jun;88(3):254-9. ;

Monoclonal Antibody

33.3kDa

B7-H; B7H1; PDL1; PD-L1; PDCD1L1; PDCD1LG1