Mouse Monoclonal Antibody to PYCARD | ProMab 31008 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to PYCARD

catalog :

31008

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1C3D3

The same clone is also sold as:

Novus Biologicals: NBP2-61676
Abnova: MAB17216

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry

product information

Catalog :

31008

Title :

Mouse Monoclonal Antibody to PYCARD

Species :

Human;

Clone :

1C3D3;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.;

Immunogen :

Purified recombinant fragment of human PYCARD (AA: 1-120) expressed in E. Coli.

Formulation :

Purified antibody in PBS with 0.05% sodium azide

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1.J Invest Dermatol. 2013 Feb;133(2):518-27. ; 2.Cancer Sci. 2010 Aug;101(8):1822-7.;

Type :

Monoclonal Antibody

MW :

21.6kDa

Aliases :

ASC; TMS; TMS1; CARD5; TMS-1