Mouse Monoclonal Antibody to MAP2K3 | ProMab 30978 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to MAP2K3

catalog :

30978

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

2E12D11

The same clone is also sold as:

Novus Biologicals: NBP2-52508
Invitrogen: MA5-38568

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry

product information

Catalog :

30978

Title :

Mouse Monoclonal Antibody to MAP2K3

Species :

Human;

Clone :

2E12D11;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.;

Immunogen :

Purified recombinant fragment of human MAP2K3 (AA: 1-138) expressed in E. Coli.

Formulation :

Purified antibody in PBS with 0.05% sodium azide

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1.Hum Mol Genet. 2013 Nov 1;22(21):4438-49. ; 2.Proteomics Clin Appl. 2010 Nov;4(10-11):816-28.;

Type :

Monoclonal Antibody

MW :

39.3kDa

Aliases :

MEK3; MKK3; MAPKK3; PRKMK3; SAPKK2; SAPKK-2