Mouse Monoclonal Antibody to MECP2 | ProMab 30905 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to MECP2

catalog :

30905

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

8H4A5B9

The same clone is also sold as:

Abnova: MAB17294
Invitrogen: MA5-38570

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry

product information

Catalog :

30905

Title :

Mouse Monoclonal Antibody to MECP2

Species :

Human;

Clone :

8H4A5B9;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females.;

Immunogen :

Purified recombinant fragment of human MECP2 (AA: 7-148) expressed in E. Coli.

Formulation :

Purified antibody in PBS with 0.05% sodium azide

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; IHC: 1/200 - 1/1000; ICC: 1/200 - 1/1000; FCM: 1/200 - 1/400

References :

1.J Pediatr Surg. 2013 Oct;48(10):2099-105. ; 2.Cell Res. 2013 Nov;23(11):1244-6.;

Type :

Monoclonal Antibody

MW :

52.4kDa

Aliases :

RS; RTS; RTT; PPMX; MRX16; MRX79; MRXSL; AUTSX3; MRXS13