Mouse Monoclonal Antibody to ANPEP | ProMab 30732 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

ProMab

product type :

antibody

product name :

Mouse Monoclonal Antibody to ANPEP

catalog :

30732

quantity :

0.1 mg

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1C7D7

The same clone is also sold as:

Invitrogen: MA1-181

reactivity :

human

application :

western blot, ELISA, flow cytometry

product information

Catalog :

30732

Title :

Mouse Monoclonal Antibody to ANPEP

Species :

Human;

Clone :

1C7D7;

lsotype :

Mouse IgG1

Size :

0.1 mg

Storage :

4℃; -20℃ for long term storage

Description :

Aminopeptidase N is located in the small-intestinal and renal microvillar membrane, and also in other plasma membranes. In the small intestine aminopeptidase N plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. Its function in proximal tubular epithelial cells and other cell types is less clear. The large extracellular carboxyterminal domain contains a pentapeptide consensus sequence characteristic of members of the zinc-binding metalloproteinase superfamily. Sequence comparisons with known enzymes of this class showed that CD13 and aminopeptidase N are identical. The latter enzyme was thought to be involved in the metabolism of regulatory peptides by diverse cell types, including small intestinal and renal tubular epithelial cells, macrophages, granulocytes, and synaptic membranes from the CNS. Human aminopeptidase N is a receptor for one strain of human coronavirus that is an important cause of upper respiratory tract infections. Defects in this gene appear to be a cause of various types of leukemia or lymphoma.

Immunogen :

Purified recombinant fragment of human ANPEP (AA: Extra(781-967)) expressed in E. Coli.

Formulation :

Purified antibody in PBS with 0.05% sodium azide.

Applications :

ELISA: 1/10000; WB: 1/500 - 1/2000; FCM: 1/200 - 1/400

References :

1. Br J Cancer. 2013 Feb 5;108(2):420-8. ; 2. Ann Surg Oncol. 2012 Jul;19 Suppl 3:S539-48.

Type :

Monoclonal Antibody

MW :

110kDa

Aliases :

APN; CD13; LAP1; P150; PEPN; GP150